The Effects of Early Parenteral Amino Acids on Sick Premature Infants.

Objectives To study the effects of early parenteral amino acid administration on body weight, fluid compartments and metabolic parameters during the first week of life in sick premature infants. Methods Appropriate for gestational age, sick premature infants were randomized into two groups. Group A infants (n=8, birth weight 1258±339 g) were supplemented with amino acids starting within 24 h of birth and advanced to 2.5 g/kg per day by day 3. Group G infants (n=9, birth weight 1182±214 g) received amino acids starting on day 4 of life. Energy intake was comparable in the 2 groups. Amino acid concentrations and nitrogen balance studies were performed on day 3 of life. Total body water and extracellular water were measured on day 1 and 8 and change in intracellular volume was calculated. Results There was no significant difference between the 2 groups in terms of weight, intracellular volume change from day 1 to day 8 of life, despite a significant (P<0.01) difference in protein intake. Plasma ammonia levels were comparable in the 2 groups, but plasma urea levels were significantly higher in group A vs. group G infants (7.2±3.4 mmol/L vs. 3.2±1.2 mmol/L respectively, P<0.01). Nitrogen balance was positive in all group A infants and negative in group G infants. Nitrogen loss was inversely correlated with energy intake in group G infants (P<0.05). The mean plasma amino acid concentrations in group A infants (compared to those of group G) were within previously reported ranges in older premature infants. Conclusions There was no significant effect on body weight and redistribution of body fluid compartments in infants receiving amino acids early during the first week of life. Serum urea concentrations were significantly higher in infants receiving early amino acids. Nitrogen losses in infants who did not receive amino acids were inversely correlated with energy intake during the first 3 days of life.

Effects of High and Low Sodium Diet on Plasma Amino Acid Levels in Korean Adult Women

This study was performed to determine the effect of dietary Na levels on plasma amino acid levels. Plasma amino acid levels were compared in 20 adult healthy women subjects who were given high Na diet (290.48 mEq/day : NaCl 17 g) or low Na diet (51.26 mEq/day : NaCl 3 g) for subsequent 6 days. Plasma essential amino acids levels were significantly decreased (36%) while plasma non-essential amino acids levels were significantly increased (22%) when subjects were given low Na diet (p < 0.001). Among essential amino acids, threonine was decreased (74%) significantly when subjects were given low Na diet (p < 0.01). Among nonessential amino acids, serine (49%), proline (20%) and aspartic acid (14%) were increased (p < 0.01), while arginine (48%) and glutamic acid (27%) were decreased (p < 0.001). In conclusion, dietary Na contents seemed to be an important factor to affect plasma amino acid levels. It would be appropriate to decrease the dietary Na intakes level considering the various clinical effects of dietary Na on the body fluid. For the patients who need low Na diet, it would be suggested that the level of dietary proteins should be carefully considered along with dietary Na manipulation.

The Effects of N-acetylcysteine on Plasma Amino-acids in Animals With Fulminant Hepatic Failure / 中国药房

OBJECTIVE:To investigate the relationship between therapeutic effects of N-acetylcysteine(NAC) on animals with fulminant hepatic failure and contents of plasma amino-acids METHODS:Plasma amino-acids were analysed as their precolumn derivatives with O-phthol-dialdehyde by reversed-phase high-performance liquid chromatographic separation and fluorescence detection RESULTS:NAC could decrease the contents of plasma amino-acids,increase the ratio of BCAA/AAA and decrease the mortality of fulminant hepatic failure animals CONCLUSION:Therapeutic effects of NAC on animals with fulminant hepatic failure were related to its effect on the contents of plasma amino-acids

Plasma amino acid changes in acute infantile diarrhea.

During the acute phase of diarrhea, there was an increase in plasma level of phenylalanine while other plasma amino acids did not increase or decrease. The addition of amino acid in ORS was not justified during acute infantile diarrhea.

INTERRELATIONSHIP BETWEEN PLASMA AMINO ACID LEVEL AND AGE / 营养学报

The plasma ammo acid levels in 21 centenarians(age 100-106), 21 elders (age 65-78) and 37 young human subjects (age 18-21) were determined. 17 of 24 amino acids studied showed lower values in centenarian and elder groups than those in young group (p