RESUMEN
Na+-K+-ATPase activity of the erythrocyte plasma membrane in noninsulin-de- pendent diabetes mellitus (NIDDM) was studied together with the red cell deform-ability (RCD) and other influencing factors. Comparing with the normal controls, Na+-K+-ATPase activity, Mg++-ATPase activity, and RCD in diabetics were significantly decreased, and the erythrocyte membrane cholesterol and lipid peroxide, fasting blood glucose, and glycosylated hemoglobin were significantly increased. The change of Na+-K+-ATPase activity was positively correlated with RCD, and inversely correlated with fasting blood glucose, erythrocyte membrane cholesterol, and lipid peroxide. The results suggested that the change of Na+-K+-ATPase activity in erythrocyte may contribute to the alterations of RCD in diabetics
RESUMEN
Red cell deformability in diabetics is much lower than that in normal controls. In patients with diabetic retinopathy, the decrease of red cell deformability is much more prominent than in patients without. Urinary albumin excretion rate in diabetic patients is inversely correlated with red cell deformability .The data above suggest that there is a close relationship between decreased red cell deformability and microangtopathy in diabetic patients