RESUMEN
Rumex nepalensis Spreng. (Polygonaceae) commonly known as Nepal Dock has wide-spectrum therapeutic potencies and is extensively used for centuries in traditional medicine systems. The leaves of this plant are edible and a rich source of natural antioxidants. They act as a possible food supplement and are largely used in pharmaceutical industry. Extracts and metabolites from this plant exhibits pharmacological activities including anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral, insecticidal, purgative, analgesic, antipyretic, anti-algal, central nervous system depressant, genotoxic, wound healing and skeletal muscle relaxant activity. Due to its remarkable biological activities, it has the potential to act as a rich source of drug against life threatening diseases. However, more studies are needed to scientifically validate the traditional uses of this plant, beside isolating and identifying their active principles and characterizing the mechanisms of action. We present herein a critical account of its botany, ecology, traditional uses, phytoconstituent profile and major pharmacological activities reported in recent years and therefore will provide a source of information on this plant for further studies.
RESUMEN
A new napthalenone, rumexone A (1), was isolated from the roots of Rumex nepalensis. The structure of 1 was elucidated by extensive spectroscopic analyses, including 1D and 2D NMR spectra and MS data. Its cytotoxic effect was evaluated using four clinically relevant human cancer cell lines, gastric carcinoma SGC7901, breast carcinoma MDA-MB-231, lung carcinoma A549, and hepatocellular carcinoma HepG2.
RESUMEN
Objective: To investigate the chemical constituents from the ethyl acetate extracts in the roots of Rumex nepalensis. Methods: The compounds were isolated by using various chromatographic techniques, such as silica gel column, Sephadex LH-20 column, and semi-preparative HPLC. The structures of these compounds were determined by spectral data analyses. Results: Sixteen compounds were obtained and identified as ferulic acid (1), 7-hydroxy-5-methoxyphthalide (2), methyl 2-acetyl-3,5-dihydroxyphenylacetate (3), methylorsellinate (4), methyl p-hydroxycinnamate (5), 1-(2-Hydroxy-5-Methyl-phenyl)-ethanon (6), methyl syringate (7), 1-(2,4-dihydroxy-6-methylphenyl)-ethanon (8), 4-hydroxy-benzeneethanol (9), isovanillin (10), fallacinol (11), 7-hydroxy-2-methyl-5-methylchromone (12), 3-acetyl-2-methyl-1,5-dihydroxy-2,3-epoxynaphthoquinol (13), emodin (14), chrysophanol (15), and physcion (16). Conclusion: Compounds 12 and 13 are isolated from this plant for the first time, and compounds 1-11 are firstly isolated from the plants of Rumex L..