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Psychiatry Investigation ; : 876-878, 2017.
Artículo en Inglés | WPRIM | ID: wpr-44333

RESUMEN

In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5' region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p < 0.001, corrected p=0.035). This indicates that genetic variations in the 5' region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.


Asunto(s)
Niño , Humanos , Trastorno del Espectro Autista , Trastorno Autístico , Predisposición Genética a la Enfermedad , Variación Genética , Haplotipos , Regiones Promotoras Genéticas , Semaforinas
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