High risk factors in images for infiltrating lung adenocarcinoma manifesting as peripheral ground-glass nodules / 中国胸心血管外科临床杂志

@#Objective     To explore the correlation between the imaging features of peripheral ground-glass pulmonary nodules and the invasion degree of lung adenocarcinoma, and the high risk factors for infiltrating lung adenocarcinoma under thin-slice CT, which provides some reference for clinicians to plan the surgical methods of pulmonary nodules before operation and to better communicate with patients, and assists in building a clinical predictive model for invasive adenocarcinoma. Methods    Clinical data of the patients with peripheral ground-glass pulmonary nodules (diameter≤3 cm) in thin-slice chest CT in the First Affiliated Hospital of Soochow University from January 2019 to January 2020 were continuously collected. All patients underwent thin-slice CT scan and thoracoscopic surgery in our center. According to the pathological examination results, they were divided into two groups: an adenocarcinoma lesions before infiltration group, and an invasive lung adenocarcinoma group. The thin-slice CT imaging parameters of pulmonary nodules were collected. The nodular diameter, mean CT value, consolidation tumor ratio (CTR), nodular shape, vacuolar sign, bronchial air sign, lobulation sign, burr sign, lesion boundary, pleural depression sign, vascular cluster sign and other clinical data were collected. Univariate and multivariate analyses were conducted to analyze the independent risk factors for the infiltrating lung adenocarcinoma, and to analyze the threshold value and efficacy of each factor for the identification of infiltrating lung adenocarcinoma. Results     Finally 190 patients were enrolled. There were 110 patients in the adenocarcinoma lesions before infiltration group, including 21 males and 89 females with a mean age of 53.57±10.90 years, and 80 patients in the invasive lung adenocarcinoma group, including 31 males and 49 females with a mean age of 56.45±11.30 years. There was a statistical difference in the mean CT value, nodular diameter, CTR, gender, smoking, nodular type, nodular shape, vacuolar sign, lobulation sign, burr sign, lesion boundary, pleural depression sign, vascular cluster sign between the two groups (P<0.05). However, there was no statistical difference between the two groups in age (P=0.081), lesion site (P=0.675), and bronchial air sign (P=0.051). Multiple logistic regression analysis showed that nodular diameter, mean CT value, CTR and lobulation sign were independent risk factors for differentiating preinvasive adenocarcinoma from invasive adenocarcinoma. At the same time, the threshold value was calculated by Youden index, indicating that the CTR was 0.45, the nodal diameter was 10.5 mm and the mean CT value was –452 Hu. Conclusion     In the peripheral ground-glass pulmonary nodules, according to the patient's CT imaging features, such as mixed ground-glass nodules, irregular shapes, vacuoles, short burrs, clear boundaries, pleural indentations, and vascular clusters, have a certain reference value in the discrimination of the invasion degree of ground-glass pulmonary nodules. At the same time, it is found in this research that peripheral ground-glass pulmonary nodules with diameter greater than 10.5 mm, CT value greater than –452 Hu, CTR greater than 0.45 and lobulation sign are more likely to be infiltrating lung adenocarcinoma.

Falcine Sinus: Incidence and Imaging Characteristics of Three-Dimensional Contrast-Enhanced Thin-Section Magnetic Resonance Imaging

OBJECTIVE: To evaluate the incidence, characteristics, and variations of the falcine sinus with contrast-enhanced three-dimentional (3D) thin-section magnetic resonance (MR) images. MATERIALS AND METHODS: retrospective review identified 1531 patients (745 males and 786 females, 2 months to 85 years) who underwent cranial MR imaging including T1-weighted imaging, T2-weighted imaging, T2-weighted fluid-attenuated inversion recovery, contrast-enhanced 3D thin-section sagittal scans, and MR venography, from June 2014 to January 2016. The incidence, characteristics of the falcine sinus, and coexisted intracranial lesions were confirmed by two neuroradiologists. RESULTS: Falcine sinuses were identified in 81 (38 males and 43 females) cases (5.3%, 81/1531, 5 months to 76 years of age) with calibers ranging from 2.3 mm to 17.0 mm. Three major forms of falcine sinuses were defined: arch-like (n = 47), stick-like (n = 22), and bifurcated (n = 12). Persistent falcine sinuses were found in 57 cases, among which 3 cases showed complicated cerebral anomalies, and 2 cases showed smaller straight sinuses. Recanalization of falcine sinuses were found in 24 cases, including 17 cases with tumor compression, 6 cases with cerebral venous sinus thrombosis, and one case with hypertrophic meningitis. CONCLUSION: Falcine sinus is not as rare as has been reported previously. Most falcine sinuses are not associated with congenital cerebral abnormalities. Diseases that cause increased pressure in the venous sinus may lead to recanalization of falcine sinus. Illustrating the characteristics of falcine sinus may prompt a more comprehensive understanding and diagnosis of associated diseases, and avoid potential surgical damage in the future.

Improvement in specimen preparation of ultra-thin section staining for transmission electron microscopy / 第二军医大学学报

Objective: To improve the staining efficiency and quality of biological specimens ultra-thin section for transmission electron microscopy. Methods: The "plug-in staining method" and continuous staining were developed by modifying the traditional staining method. Results: Using our method, we completed the electron staining of a large number of ultra-thin sections of biological specimens of within a short period of time. Conclusion: Compared with traditional method, the new method can save time and drug, and reduce the possibility of staining contamination. The ultrastructure observed by electron microscope is more clear and distinct.

Resonancia magnética de rodilla: estudio comparativo entre secuencia spin echo volumétrica y tradicional de corte grueso / Knee MRI: comparative study between volumetric spin scho sequences and conventional thick-slice imaging

The development of new MRI technologies has favoured the use of sequences that significantly improve the spatial resolution of this imaging method, thus yielding thin-section images that allow volumetric analysis. We present our experience at Clínica Vespucio related to a routine knee MRI protocol, performed on 45 patients who underwent conventional proton density-weighted spin-echo sequence (PDFS) 3-mm section thickness along with proton density-weighted sequence of 1.2- mm thin-section, both with fat suppression technique. In most cases, the thin-section PDFS allows a better anatomical characterization of lesions, particularly meniscal and condral injuries, with a minimum increase in image acquisition time.

El desarrollo de nuevas tecnologías en resonancia magnética ha favorecido el uso de secuencias que mejoran significativamente la resolución espacial del método, obteniendo imágenes de cortes finos que permiten análisis volumétrico. Se presenta la experiencia en Clínica Vespucio en un protocolo rutinario de estudio de rodilla, con evaluación de 45 pacientes consecutivos a los que se les realizó secuencia tradicional de densidad protónica con saturación grasa (DPFS) de corte grueso (3 mm) y secuencia DPFS volumétrica de corte fino (1,2 mm). En la mayoría de los casos es posible realizar mejor caracterización anatómica de las lesiones, principalmente meniscales y condrales, con un mínimo aumento en el tiempo de estudio.

A Narrow Internal Auditory Canal with Duplication in a Patient with Congenital Sensorineural Hearing Loss

A narrow internal auditory canal (IAC) with duplication is a rare anomaly of the temporal bone. It is associated with congenital sensorineural hearing loss. Aplasia or hypoplasia of the vestibulocochlear nerve may cause the hearing loss. We present an unusual case of an isolated narrow IAC with duplication that was detected by a CT scan. In this case, the IAC was divided by a bony septum into an empty stenotic inferoposterior portion and a large anterosuperior portion containing the facial nerve that was clearly delineated on MRI.

1024 Matrix Image Reconstruction: Usefulness in High Resolution chest CT

PURPOSE: We tried to evaluate whether high resolution chest CT with a 1,024 matrix has a significant advantage in image quality compared to a 512 matrix. MATERIALS AND METHODS: Each set of 512 and 1024 matrix high resolution chest CT scans with both 0.625 mm and 1.25 mm slice thickness were obtained from 26 patients. Seventy locations that contained twenty-four low density lesions without sharp boundary such as emphysema, and forty-six sharp linear densities such as linear fibrosis were selected; these were randomly displayed on a five mega pixel LCD monitor. All the images were masked for information concerning the matrix size and slice thickness. Two chest radiologists scored the image quality of each arrowed lesion as follows: (1) undistinguishable, (2) poorly distinguishable, (3) fairly distinguishable, (4) well visible and (5) excellently visible. The scores were compared from the the aspects of matrix size, slice thickness and the different observers by using ANOVA tests. RESULTS: The average and standard deviation of image quality were 3.09 (+/-.92) for the 0.625 mmx512 matrix, 3.16 (+/-.84) for the 0.625 mmx1024 matrix, 2.49 (+/-1.02) for the 1.25 mmx512 matrix, and 2.35 (+/-1.02) for the 1.25 mmx1024 matrix, respectively. The image quality on both matrices of the high resolution chest CT scans with a 0.625 mm slice thickness was significantly better than that on the 1.25 mm slice thickness (p < 0.001). However, the image quality on the 1024 matrix high resolution chest CT scans was not significantly different from that on the 512 matrix high resolution chest CT scans (p = 0.678). The interobserver variation between the two observers was not significant (p = 0.691). CONCLUSION: We think that 1024 matrix image reconstruction for high resolution chest CT may not be clinically useful.

The Value of Coronal Image Reconstructions of HRCT using MDCT for the Assessment of Bronchiectasis: Experiment with 64 MDCTs

PURPOSE: The aim of our study was to evaluate the value of coronal image reconstructions of HRCT with using 64 MDCT scans for the assessment of bronchiectasis. MATERIALS AND METHODS: Chest CT scans (0.6-mm collimation, table speed of 14 mm/sec and a rotation time of 0.5 sec) that employed 64 MDCT images (Somatom Sensation 64, Siemens) without contrast media were performed in 56 patients (21 males and 35 females, mean age: 55 years) who displayed hemoptysis. The images were reconstructed with a 1 mm slice thickness in the axial (10 mm apart) and coronal (10 mm apart) planes with using a high frequency algorithm, and they were sent to PACS monitors. The axial images were assessed with and without the coronal images by two radiologists at two separate occasions. The presence of bronchiectasis was decided upon by consensus diagnosis of the two radiologists. The detection rates of bronchiectasis were compared between the readings with using the axial images alone and the readings with using both the axial and coronal images. RESULTS: The detection rate of bronchiectasis was significantly higher with using both the axial and coronal images than with using with axial images alone (82.1%, 46/56 patients Vs 64.3%, 36/56 patients, respectively, p=0.001). The detection rates for all the lobes, except for the superior division of the left upper lobe, were significantly improved with using both the axial and coronal images (RUL; p=0.013, RML; p=0.002, RLL; 0.024, Lt lingular segment; p=0.004, LLL; p=0.018). CONCLUSION: The coronal images of HRCT with using 64 MDCT improved the detection rate of bronchiectasis in the patients with hemoptysis when they were used in conjunction with the standard axial images. We suggest that HRCT with the coronal images should be obtained for the patients with hemoptysis, despite that the simple chest radiographs are often normal or they have non-specific findings.

The Value of Coronal Image Reconstructions of HRCT using MDCT for the Assessment of Bronchiectasis: Experiment with 64 MDCTs

PURPOSE: The aim of our study was to evaluate the value of coronal image reconstructions of HRCT with using 64 MDCT scans for the assessment of bronchiectasis. MATERIALS AND METHODS: Chest CT scans (0.6-mm collimation, table speed of 14 mm/sec and a rotation time of 0.5 sec) that employed 64 MDCT images (Somatom Sensation 64, Siemens) without contrast media were performed in 56 patients (21 males and 35 females, mean age: 55 years) who displayed hemoptysis. The images were reconstructed with a 1 mm slice thickness in the axial (10 mm apart) and coronal (10 mm apart) planes with using a high frequency algorithm, and they were sent to PACS monitors. The axial images were assessed with and without the coronal images by two radiologists at two separate occasions. The presence of bronchiectasis was decided upon by consensus diagnosis of the two radiologists. The detection rates of bronchiectasis were compared between the readings with using the axial images alone and the readings with using both the axial and coronal images. RESULTS: The detection rate of bronchiectasis was significantly higher with using both the axial and coronal images than with using with axial images alone (82.1%, 46/56 patients Vs 64.3%, 36/56 patients, respectively, p=0.001). The detection rates for all the lobes, except for the superior division of the left upper lobe, were significantly improved with using both the axial and coronal images (RUL; p=0.013, RML; p=0.002, RLL; 0.024, Lt lingular segment; p=0.004, LLL; p=0.018). CONCLUSION: The coronal images of HRCT with using 64 MDCT improved the detection rate of bronchiectasis in the patients with hemoptysis when they were used in conjunction with the standard axial images. We suggest that HRCT with the coronal images should be obtained for the patients with hemoptysis, despite that the simple chest radiographs are often normal or they have non-specific findings.

The Utility of Thin Section CT in Pediatric Nasal Bone Fracture

The incidence of facial bone fracture in children is relatively uncommon compared with that in adults. Nasal bone fracture in children may cause cosmetic or functional disabilities, so the patients should be properly treated. The diagnosis of nasal bone fracture in children is difficult because the pediatric patient does not permit the most gentle examination and x-ray examination. Failure to confirm a suspected fracture on radiography should not always deter treatment. Clinical judgment should overrule other consideration. The advent of computerized tomographic (CT) scanning has improved the radiologic diagnosis of facial fractures. But the facial bone CT is unable to image the nasal structures in detail. So the authors have performed thin section computed tomography in such children, and compares the accuracy of child`s nasal bone fractures of thin section CT scan with traditional CT scan.

THIN SECTIONAL ANATOMY AND HRCT OF FACIAL RECESS AND ITS ADJACENT STRUCTURES / 解剖学报

0.05).Conclusion The thin section collodion anatomy of temporal bone area,combined with the images of HRCT can clearly delineate the details of facial recess and its relative structures.

Thin Section Helical CT Findings of Klatskin Tumor and Benign Stricture: Cholangiographic Correlation

PURPOSE: The purpose of this study was 1) to describe the thin section helical CT findings of hilar cholangiocarcinoma and of benign stricture, and to discuss the differential points between the two disease entities and 2) using cholangiographic correlation, to evaluate the diagnostic accuracy of helical CT in determining the extent of hilar cholangiocarcinoma. MATERIALS AND METHODS: Twenty-seven patients with hilar cholangiocarcinoma and eight with benign biliary dilatation were studied. All except four with hilar cholangiocarcinoma, who underwent CT using a conventional scanner, were studied with two-phase helical CT. In all patients, cholangiographs were obtained by digital fluoroscopy after the injection of contrast materials into PTBD catheters. The level of obstruction was classified according to Bismuth, and 35 CT scans were studied blindly and retrospectively by two radiologists. The findings were analyzed for the presence of tumor, and then divided into two groups (cholangiocarcinomas and benign strictures), and the positive predictive value was calculated. The CT images of klatskin tumor were analyzed with special emphasis on the level and shape of the hilar obstruction. The level of biliary obstruction and extent of the tumor were carefully correlated with the results of cholangiography. RESULTS: Thin-section spiral CT correctly identified all tumor mass as a focal wall thickening obliterating the lumen. On arterial/portal phase CT scanning, 81% of infilterative tumors showed high attenuation. In all patients, differentiation between benign stricture and klatskin tumor was possible ; correct identification of the level of obstruction and extent of tumor, according to Bismuth's classification, was possible in 63% of cases. CONCLUSION: For correct diagnosis of hilar cholangiocarcinoma and differentiation of benign stricture, helical CT was highly accurate and effective. Because of limital Z-axis resolution, however, the exact intraductalextent of the tumor was less accorately diagnosed.