Coagulation Disorders in Bullous Pemphigoid and Its Mechanism / 中国医学科学院学报

Bullous pemphigoid(BP)is an autoimmune blister disease caused by antibodies to the basement membrane zone.It usually exhibits tense bullae in skin and mucous membrane.BP patients can suffer from thrombosis due to hypercoagulation and/or hemorrhage due to the presence of anti-coagulation factors,which may be explained by the eosinophils,antibodies to the coagulation factors,and fibrinolytic system hyperactivity or inhibition.

Progress of anticoagulant system and thrombotic diseases in neonates / 国际儿科学杂志

Newborns are prone to coagulation dysfunction in stress after birth,which is related to their imperfect coagulation and anticoagulation systems.The neonatal anticoagulation system is in a process of continuous development and maturation,and its physiological changes are very complicated.In recent years,research on neonatal coagulation and anticoagulation systems has got a lot of achievement,but there is still a lack of large-scale randomized studies for a reference range of neonatal anticoagulant factors.Neonatal thrombotic diseases are more and more common.The treatment includes anticoagulative and thrombolytic therapy.

Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia

Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the Japanese and Chinese involve dysfunction of the activated protein C (APC) anticoagulant system caused by abnormal protein S and protein C molecules. Approximately 50% of Japanese and Chinese individuals who develop venous thrombosis have reduced activities of protein S. The abnormal sites causing the protein S molecule abnormalities are distributed throughout the protein S gene, PROS1. One of the most common abnormalities is protein S Tokushima (K155E), which accounts for about 30% of the protein S molecule abnormalities in the Japanese. Whether APC dysfunction occurs in other Asian countries is an important aspect of mapping thrombophilia among Asians. International surveys using an accurate assay system are needed to determine this.