RESUMEN
@#Objective To investigate the efficacy and safety of a reduced-dosage rituximab (RTX) treatment regimen for neuromyelitis optica spectrum disorders (NMOSD) under B cell monitoring.Method Clinical data from 35 patients with NMOSD who were regularly followed up in the Department of Neurology of the First Affiliated Hospital of Soochow University from December 2016 to June 2019 were collected.They were divided into rituximab reduction group under B cell monitoring,azathioprine group and cyclophosphamide group.Differences in the indexes including the Expanded Disability Status Scale (EDSS) score,possibility of no recurrence,and adverse drug reactions were used to evaluate the efficacy and safety of the three treatment regimens.Results (1)The EDSS score of the RTX group was significantly lower than that of the AZA group before and after treatment (P<0.05).(2)The relapse risk of the RTX and CTX groups was significantly lower than that of the AZA group (Log-rank χ2=9.147,P=0.01).(3)The proportion of total adverse events in the RTX group was less than that in the CTX group.The glucocorticoids withdrawal rate in the RTX group was higher than that of the AZA group and the CTX group (P<0.05),and the difference was statistically significant.(4)The mean interval of treatment in RTX group was 7.00 (6.0,10.0) months.Conclusion The reduced-dose rituximab regimen under B cell monitoring is generally safe and effective in the treatment of NMOSD,which can prolong the medication interval and reduce the medication expenses of patients.
RESUMEN
The vibrational spectral differences of normal and lung cancer cells were studied for the development of effective cancer cell screening by means of attenuated total reflection infrared spectroscopy. The phosphate monoester symmetric stretching nus(PO3(2-)) band intensity at ~970 cm-1 and the phosphodiester symmetric stretching nus(PO2-) band intensity at ~1,085 cm-1 in nucleic acids and phospholipids appeared to be significantly strengthened in lung cancer cells with respect to the other vibrational bands compared to normal cells. This finding suggests that more extensive phosphorylation occur in cancer cells. These results demonstrate that lung cancer cells may be prescreened using infrared spectroscopy tools.