1.
Chongqing Medicine
;
(36): 1723-1726, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-692008
RESUMEN
Objective To investigate the mechanism of miRNA-129-5p in epithelial-mesenchymal transition (EMT)of biliary atresia.Methods Constructed bile duct epithelial EMT cell model (the experimental group) induced by TGF-β1,detected the expressions of EMT related markers and miRNA-129-5p.While miRNA-129-5p precursor was transfected,the expressions of EMT related markers and extracellular matrix were contrasted between the original and the renovated biliary epithelial cells.Results In the experimental group,extrahepatic bile duct showedEMT,the expression of miRNA-129-5p was decreased (P<0.05),overexpression of miRNA-129-5p could inhibit the progression of EMT (P<0.05).Conclusion miRNA-129-5p may relate to EMT by regulating the expression of TGF-β1.