RESUMEN
Plexiform fibrohistiocytic tumor (PFHT) is a rare mesenchymal neoplasm of intermediate malignancy and possibly of myofibroblast origin. It is morphologically divided into 3 groups: cellular, fibrous, and mixed. A 4-year-old girl presented with an irregular shaped subcutaneous mass on her left popliteal fossa for 6 months. The biopsy specimen showed multinodular tumor islands extending from dermis to subcutaneous layer, composed of histiocytes and osteoclast-like multinucleated giant cells, and circumscribed by fibrous tissue. Immunohistochemical staining was positive for CD68 in giant cells and histiocyte-like cells within tumor islands and faintly positive for smooth muscle actin around nodules. A cellular variant of PFHT was eventually diagnosed. Although PFHT comprises morphologically normal cells, it has the biological potential for malignant change and distal metastasis. Therefore, PFHT is categorized as a neoplasm of intermediate malignancy, and wide total excision with close follow-up is crucial.
Asunto(s)
Preescolar , Femenino , Humanos , Actinas , Biopsia , Dermis , Células Gigantes , Histiocitos , Islas , Músculo Liso , Miofibroblastos , Metástasis de la NeoplasiaRESUMEN
A 2-month-old infant presented with a circumscribed nodule on left foot since birth. Excision biopsy showed juvenile xanthogranuloma, an uncommon diagnosis in an unusual site; common sites being head and neck. Uncommon sites are groin, genital organs, limbs and even internal organs. It carries a favorable prognosis.
RESUMEN
BACKGROUND: Malignant fibrous/fibrohistiocytic tumors are uncommon soft tissue tumors which gives dermatologists special attention on differential diagnosis. However, there has not yet been a multicenter study on these tumors in Korea. OBJECTIVE: The aim of this study was to investigate the epidemiology and clinical features of malignant fibrous/ fiborhistiocytic tumors. METHODS: A total of 62 patients from 11 training hospitals who had been confirmed with malignant fibrous/ fibrohistiocytic tumor were studied. A retrospective analysis of hospital records served as the data source for this study. RESULTS: Among patients with malignant fibrous/fibrohistiocytic tumors, the most common tumor type was dermatofibrosarcoma protuberance followed by malignant fibrohistiocytic. The male to female ratio among subjects was 1.38 to 1 and the mean age was 44 years old. Of the common complaints recorded, asymptomatic mass was the most frequent. The mean size of the subjects' tumors was 2.9 cm in the long axis and 2.3 cm in the short axis with a mean tumor thickness of 2.1 mm. The most common site for tumors was the back followed by the thigh. The recurrence rate after primary treatment was 14.5% and metastasis developed in 5 of 62 patients. CONCLUSION: This study is expected to be helpful for understanding the clinical and pathological characteristics of malignant fibrous/fibrohistiocytic tumors.
Asunto(s)
Femenino , Humanos , Masculino , Vértebra Cervical Axis , Almacenamiento y Recuperación de la Información , Dermatofibrosarcoma , Diagnóstico Diferencial , Registros de Hospitales , Corea (Geográfico) , Metástasis de la Neoplasia , Recurrencia , Estudios Retrospectivos , MusloRESUMEN
Presentamos el caso de un paciente varón de 49 años, portador de fibriohistiocitoma maligno de la laringe. Hacemos un análisis de su presentación clínica, la terapéutica y su evolución. Se revisó la literatura, donde se encuentra unos pocos casos publicados hasta la fecha en esa localización.
We report the case of a 49-year-old male patient, with a laringeal malignant fibrohistiocitoma. We found a few cases reported in this localization.
RESUMEN
Plexiform fibrohistiocytic tumor (PFT) is a rare, low-grade soft tissue tumor that occurrs primarily in children and young adults. The most common location of PFT is the upper extremity, and there are very few reports of PFT in the neck. We report here on a case of PFT presenting as a painless subcutaneous nodule in the neck of a 46-year-old woman. Histologically, this subcutaneous tumor was composed of a plexiform proliferation of histiocyte-like cells and fibroblast-like cells along with a few multinucleated osteoclast-like giant cells. Immunohistochemically, the tumor cells were positive for vimentin, CD68 and smooth muscle actin (SMA).
Asunto(s)
Niño , Femenino , Humanos , Persona de Mediana Edad , Adulto Joven , Actinas , Células Gigantes , Músculo Liso , Cuello , Extremidad Superior , VimentinaRESUMEN
A plexiform fibrohistiocytic tumor is a low-grade malignant mesenchymal neoplasm of myofibroblastic origin, with the capacity for biphasic differentiation toward a fibroblastic or histiocyte-like morphology. We report a case of myxoid plexiform fibrohistiocytic tumor occurring on the left upper arm in a 34-year old man. The lesion was a yellowish-to-pinkish color, rounded, pedunculated tumor with a short pedicle, measuring 1x1x1.5cm. Histopathological examination revealed a multinodular biphasic proliferation of fibroblast- like and histiocyte-like cells with a few osteoclast-like giant cells. This case is notable for the rare myxoid changes. To the best of our knowledge, this is the first report of a plexiform fibrohistiocytic tumor in the Korean dermatological journals.
Asunto(s)
Adulto , Humanos , Brazo , Fibroblastos , Células Gigantes , MiofibroblastosRESUMEN
Cutaneous metastasis from visceral malignancies shows diverse manifestations. Very rarely, cutaneous metastasis mimicks benign mesenchymal tumors. We describe a case in which metastasis from gastric adenocarcinoma mimicked fibrohistiocytic tumors. The diagnosis of cutaneous metastasis was confirmed by the presence of atypical cells and signet-ring cells, positive staining for mucin and positive immunohistochemical stainings for keratins, carcinoembryonic antigen(CEA), and lysozyme within the tumor cells infiltrated in the irregular, intertwining bundles of collagen in the reticular dermis.