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Objective To investigate the efficacy and safety of Irbesartan Hydrochlorothiazide combined with Metoprolol as initial therapy in the treatment of heart failure in the elderly.Methods A total of 128 elderly patients with heart failure admitted into our hospital from September 2017 to August 2018 were randomly divided into Group A(n=64)and Group B(n=64).Group A was treated with oral Irbesartan Hydrochlorothiazide tablets.Group B was treated with sustained-release oral Metoprolol tablets in addition to what was given in Group A.Therapeutic effects were compared between the groups.Results Compared with Group A,the effectiveness rate of group B was significantly improved(93.8％ vs.81.3％,x2 =4.571,P=0.033).There was no significant difference in brain natriuretic peptide (BNP),interleukin (IL)-12,left ventricular ejection fraction (LVEF),left ventricular end-systolic diameter(LVESD),or left ventricular end-diastolic diameter(LVEDD)between the two groups before treatment (P＞0.05).Compared with Group B,BNP,IL-12,LVEF,LVESD and LVEDD had significantly better profiles in Group A after treatment (P ＜ 0.05).The time-domain measurements of heart rate variability such as sequential five-minute R-R interval means(SDANN),standard deviation of the N-N interval(SDNN),percent of differences between adjacent RR intervals ＞50ms(PNN50)and root mean square of the successive differences(RMSSD)were higher in Group B than in Group A after treatment.No serious adverse reactions were observed in either group,and there was no significant difference in the incidence of adverse reactions between the two groups(4.7％ vs.7.8 ％,x2 =0.533,P =0.465).Conclusions Irbesartan Hydrochlorothiazide combined with Metoprolol as initial therapy has good clinical effects in treating elderly heart failure.It can not only improve the clinical symptoms of patients,but also ensure clinical medication safety.
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Objective To investigate the effects of irbesartan hydrochlorothiazide combined with candesartan cilexetil in the treatment of elderly patients with hypertension and its protective effect on cardiac function.Methods 180 elderly patients with hypertension were selected,and they were randomly divided into observation group and control group according to the digital table,90 cases in each group.The observation group was given irbesartan hydrochlorothiazide combined with candesartan treatment,the control group was given candesartan.The heart function improvement after treatment,clinical efficacy and patients in hospitalization,complications,critical events and new death of the two groups were compared.Results After treatment,the heart rate,EVDD,SBP and other indicators of the two groups declined,which of the observation group[(56.14 ± 6.15)mm,(112.12 ± 20.12)mmHg,(70.45 ± 8.69/min)]were lower than the control group[(60.12 ± 6.78) mm(119.45 ± 21.45) mmHg,(82.12 ± 9.12/ min)],there were significant differences between the two groups (t1 =4.124,P =0.000;t2 =2.364,P =0.019;t3 =8.788,P =0.000).The total effective rate of the observation group was 93.33％,which was higher than 74.44％ of the control group,there was significant difference between the two groups (x2 =11.879,P =0.000).Conclusion Irbesartan hydrochlorothiazide combined with candesartan in the treatment of elderly hypertensive patients can effectively improve the heart function of patients,has significant effect.
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Objective To investigate the clinical efficacy of irbesartan hydrochloride and its effect on serum levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in patients with essential hypertension.Methods From 86 patients with essential hypertension who were treated in our hospital from July 2014 to September 2016 were randomly divided into experimental group and control group.43 patients in the control group were treated with irbesartan tablets.Group 43 patients were treated with irbesartan hydrochlorothiazide tablets,and the clinical efficacy,blood pressure and serum TNF-α,IL-6 factor and the incidence of adverse reactions were compared between the two groups.Results The effective rate was 93.02％in experimental group the total effective rate control group was 76.74％,the total effective rate of the experimental group was significantly higher than the control group,the difference was statistically significant(P<0.05).Before and after treatment,the systolic and diastolic blood pressure were higher in the experimental group and the control group,and there was no significant difference between the two groups.After eight weeks of treatment,Systolic and diastolic blood pressure were decreased,and the degree of decline in the experimental group was more obvious,the difference between the two groups was significant,statistically significant(P<0.05).There was no significant difference in serum TNF-α and IL-6 between the experimental group and the control group before treatment.After eight weeks of treatment,the serum TNF-α,IL-6 factor decreased,and the degree of decline in the experimental group was more obvious,the difference between the two groups was significant,statistically significant(P<0.05).The incidence of adverse reactions was 2.33％in 43 patients,43 cases of ankle edema in the control group,3 cases of dizziness and headache,2 cases of mild uric acid and two cases of adverse reaction.The incidence of adverse reactions was 16.28％,The incidence of adverse reactions in the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of essential hypertension with irbesartan hydrochloride is obvious,and the serum TNF-α and IL-6 are decreased and the safety is high.
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Objective To study the clinical efficacy of low dose thyroxine combined with irbesartan hydrochlorothiazide in the treatment of elderly patients with severe heart failure.Methods 100 cases of elderly patients with severe heart failure treated in our hospital from January 2013 to December 2016 were selected as the research object in this study.They were randomly divided into control group and experimental group, with 50 cases in each group.Patients in the control group were treated with conventional therapy, while the experimental group was treated with low dose thyroxine combined with irbesartan and hydrochlorothiazide.The clinical efficacy of the two group were compared and analyzed.Results After the corresponding treatment, the total effective rate of the experimental group was 88.0%,significantly higher than that of the control group(70.0%), the difference was statistically significant(P<0.05).After treatment, the experimental group of patients with left ventricular ejection fraction index, four triiodothyronine and three triiodothyronine levels were significantly higher than those before treatment, the control group of patients with left ventricular ejection fraction were significantly higher than before treatment, the difference was statistically significant(P<0.05).Conclusion Low dose thyroxine combined with irbesartan hydrochlorothiazide in the treatment of elderly patients with severe heart failure has better clinical effect, can improve the therapeutic effect in a certain extent, with further clinical promotion and application significance.
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Objective To study the clinical efficacy of low dose thyroxine combined with irbesartan hydrochlorothiazide in the treatment of elderly patients with severe heart failure. Methods 60 cases of elderly patients with severe heart failure who were admitted from January 2015 to December 2016 were selected as the research object in this study. They were randomly divided into control group and experimental group, each group was divided into two groups, each with a total of 30 cases. Patients in the control group were treated with conventional therapy, while the experimental group was treated with low dose thyroxine combined with irbesartan and hydrochlorothiazide. Comparative analysis of clinical efficacy of the experimental group and control group. Results After treatment, the total effective number of patients in the experimental group was 26 cases, the effective rate was 86.7%. The total effective number of patients in the control group was 21 cases, the effective rate was 70.0%. Therefore, the effective rate of the experimental group was significantly higher than that of the control group, with statistical difference (P<0.05). After treatment, the experimental group of patients with left ventricular ejection fraction index, four triiodothyronine and three triiodothyronine levels were significantly higher than those before treatment, the control group of patients with left ventricular ejection fraction were significantly higher than before treatment, with statistical difference (P<0.05). Conclusion Low dose thyroxine combined with irbesartan hydrochlorothiazide in the treatment of elderly patients with severe heart failure has better clinical effect, can improve the therapeutic effect in a certain extent, with further clinical promotion and application significance.intervention in two groups. Results The clinical intervention effect of the observation group was better than that of the control group, the stability of the tumor focus, the degree of pain, the quality of life and other aspects were better than the control group, the difference between the two groups was statistically significant (P<0.05). Conclusion Patients with advanced non-smal cell lung cancer chemotherapy choose psychological intervention compound sophora injection combined treatment effect is remarkable, which can effectively improve the patient's clinical symptoms and quality of life.
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Objective To study the clinical efficacy of low dose thyroxine combined with irbesartan hydrochlorothiazide in the treatment of elderly patients with severe heart failure. Methods 60 cases of elderly patients with severe heart failure who were admitted from January 2015 to December 2016 were selected as the research object in this study. They were randomly divided into control group and experimental group, each group was divided into two groups, each with a total of 30 cases. Patients in the control group were treated with conventional therapy, while the experimental group was treated with low dose thyroxine combined with irbesartan and hydrochlorothiazide. Comparative analysis of clinical efficacy of the experimental group and control group. Results After treatment, the total effective number of patients in the experimental group was 26 cases, the effective rate was 86.7%. The total effective number of patients in the control group was 21 cases, the effective rate was 70.0%. Therefore, the effective rate of the experimental group was significantly higher than that of the control group, with statistical difference (P<0.05). After treatment, the experimental group of patients with left ventricular ejection fraction index, four triiodothyronine and three triiodothyronine levels were significantly higher than those before treatment, the control group of patients with left ventricular ejection fraction were significantly higher than before treatment, with statistical difference (P<0.05). Conclusion Low dose thyroxine combined with irbesartan hydrochlorothiazide in the treatment of elderly patients with severe heart failure has better clinical effect, can improve the therapeutic effect in a certain extent, with further clinical promotion and application significance.intervention in two groups. Results The clinical intervention effect of the observation group was better than that of the control group, the stability of the tumor focus, the degree of pain, the quality of life and other aspects were better than the control group, the difference between the two groups was statistically significant (P<0.05). Conclusion Patients with advanced non-smal cell lung cancer chemotherapy choose psychological intervention compound sophora injection combined treatment effect is remarkable, which can effectively improve the patient's clinical symptoms and quality of life.
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Objective To study the clinical efficacy of irbesartan hydrochlorothiazide combined with small dose thyroxine in the treatment of severe heart failure in the elderly. Methods 100 elderly patients with severe heart failure were selected as the research object (from January 2013 to December 2016). They were randomly divided into the control group and the experimental group, with 50 patients in each group. Patients in the control group received routine treatment, including diuretic therapy, cardiac treatment, and anti heart failure treatment. The experimental group was treated with low-dose thyroxine combined with irbesartan and hydrochlorothiazide on this basis. The clinical effects of the two groups were compared and analyzed. Results After the corresponding treatment, the number of invalid cases in the experimental group was 6 cases, 16 cases were effective, 28 cases were effective,and the total effective number was 44 cases. In the control group, the number of invalid cases was 15. The effective rate of the treatment group was 88.0％, which was significantly higher than that of the control group 70％, which was statistically significant (P<0.05). After treatment, the left ventricular ejection fraction, the level of four and three, and the level of serum thyroid stimulating hormone in the experimental group were significantly higher than those before treatment, with statistical difference (P<0.05). Conclusion Small dose thyroxine combined with irbesartan and hydrochlorothiazide is effective in the treatment of severe heart failure in elderly patients, and can significantly improve the heart function of patients, and has the significance of further clinical promotion.
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Objective To investigate the comparison of clinical curative effect and inflammation factors between irbesartan hydrochlorothiazide and candesartan cilexetil in the treatment of patients with hypertension.Methods A total of 86 patients with hypertension in our hospital from June 2014 to October 2015 were collected and randomly divided into two groups, 43 cases in the control group were treated by candesartan cilexetil,43 cases in the experimental group were treated by irbesartan hydrochlorothiazide.The blood pressure, CRP, IL-6 and NO indexes were detected in the two groups and the clinical curative effect of the two groups was compared.Results The systolic pressure and diastolic pressure levels in the experimental group were significantly lower than the control group ( P <0.05 ); the serum CRP, IL -6 levels in experimental group were significantly lower than the control group, the NO level was significantly higher than the control group (P<0.05).Conclusion Irbesartan hydrochlorothiazide in the treatment of patients with hypertension has a better clinical curative effect, and higher security.
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Objective To observe and explore the effectiveness of irbesartan hydrochlorothiazide(IH) combine with Bisoprol‐ol fumarate(BIS) on youth hypertension .Methods Randomly divided 96 patients in our hospital from September 2012 to February 2015 into observation group and control group(48 cases in each/group) .the IH treatment was given to the control group based on regular drug ,while the BIS was given to the observation group on the basis of the control group .systolic pressure(SBP) ,diastic pressure(DBP) and heart rate(HR) ,left ventricular end diastolic diameter(LVEDD) ,E peak and left ventricular ejection fraction (LVEF) in the two groups before and after treatment were detected ,and comprehensive efficacy were evaluated based on blood pressure improvement .Results Before treatment ,the difference of SBP ,DBP ,HR ,LVEDD ,E peak and LVEF between the two groups was not statistically significant (P>0 .05);after treatment ,SBP ,DBP and HR were (116 .4 ± 11 .8)mm Hg ,(85 .3 ± 6 .7) mm Hg and (65 .2 ± 7 .1)times/min in the observation group ,respectively ,while in the control group ,SBP ,DBP and HR were (132 .8 ± 14 .6)mm Hg ,(96 .3 ± 6 .2)mm Hg and (75 .2 ± 8 .1)times/min ,respectively ,the difference was statistically significant(P<0 .05);after treatment ,LVEDD in observation group was significantly lower than the control group ,while LVEF ,E peak were significantly higher(P< 0 .05);the total effective rate in observation group was 95 .8% (46/48) ,while total effective rate was 75 .0% (36/48) in the control group ,the difference was statistically significant(P<0 .05) .Conclusion IH combined with BIS can significantly improve blood pressure in patients with juvenile hypertension and has significant effect ,thus it is a safe and effective therapy for juvenile hypertension .