Relación de ácidos grasos omega 6/omega 3 / Omega 6/omega 3 fatty acid ratio

La relación de ácidos grasos (AG)ω6/ω3 de la dieta contemporánea favorece a los AG ω6. El objetivo del estudio fue evaluar el efecto de dietas con cantidades crecientes de aceite de pescado (AcP), rico en AG ω3, sobre el crecimiento y las variables hematológicas de ratas macho recien destetadas de la cepa Sprague-Dawley. Los animales consumieron por un período de 31 días dietas que contenían AcP o aceite de ajonjolí (AcA) incorporado a 5, 10 ó 15% (pxp). Se observó un déficit del crecimiento como de la ingesta de alimento en los grupos que consumieron AcP. La concentración de hemoglobina (Hb) disminuyó en relación al incremento (>5% pxp) del AcP dietario. Siendo el AcP una fuente pobre de AG ω6, planteamos que la deficiencia parcial de la serie polienoica ω6 que resultó al incrementar las cantidades de AcP dietario pueden afectar el crecimiento y la eritropoyesis(AU)

The ω6/ω3 fatty acid (FA) ratio of our contemporary diet favors ω6 over ω3 FA. The object of the study was to evaluate the effect of increasing amounts of dietary fish oil, rich in ω3 FA, on growth and hematological variables of the weanling male Sprague-Dawley rat. Animals were fed diets containing either fish oil (FO) or sesame oil (SO) at 5, 10 or 15% (w/w) for 31 d. Growth retardation and reduced food intake was observed in groups fed FO. Hemoglobin (Hb) concentration diminished when the dietary FO was above 5% (w/w). FO is a poor source of ω6 fatty acids. We postulate that a partial deficiency in ω6 polyenic family, is a consequence of the increasing amounts of FO in the diets, that may affect growth and erytropoiesis. In this report we show evidence supporting the hypothesis that diets enriched with fish oil can alter normal growth and induced hematological changes in the male weanling rat(AU)

The effect of long-term supplementation with different dietary omega-6/omega-3 ratios on mineral content and ex vivo prostaglandin E2 release in bone of growing rabbits

BACKGROUND/OBJECTIVES: The aim of this research was to study the different long term effects of consumption of dietary oil sources with varying omega-6/omega-3 (omega-6/omega-3) polyunsaturated fatty acids (PUFAs) ratios on bone marrow fatty acid level, ex vivo prostaglandin E2 (PGE2) release, and mineral content of bone in rabbits. MATERIALS/METHODS: For this purpose, weaning and female New Zealand white rabbits were purchased and randomly divided into five groups and offered ad libitum diets containing 70 g/kg of added oil for 100 days. The dietary lipid treatments were formulated to provide the following ratios of omega-6/omega-3 fatty acids: 8.68 soy bean oil (SBO control), 21.75 sesame oil (SO), 0.39 fish oil (FO), 0.63 algae oil (DHA), and 0.68 algae oils (DHA/ARA). DHA and ARA are two types of marine microalgae of the genus Crypthecodinium cohnii. RESULTS: The dietary treatments had significant effects on the bone marrow fatty acids of rabbits. Rabbits fed the FO diet, containing the highest omega-3 PUFA concentration, and those fed the SBO diet showed the highest omega-6 PUFA. On the other hand, a positive correlation was observed between Ex vivo PGE2 level and the omega-6/omega-3 dietary ratio. Significant effects of dietary treatment on femur Ca, P, Mg, and Zn contents were observed in both genders. CONCLUSIONS: Findings of the current study clearly demonstrated that dietary PUFA, particularly omega-6/omega-3 and ARA/EPA ratios are important factors in determining bone marrow fatty acid profile, and this in turn determines the capacity of bone for synthesis of PGE2, thereby reducing bone resorption and improving bone mass during growth.

The effect of long-term supplementation with different dietary omega-6/omega-3 ratios on mineral content and ex vivo prostaglandin E2 release in bone of growing rabbits

BACKGROUND/OBJECTIVES: The aim of this research was to study the different long term effects of consumption of dietary oil sources with varying omega-6/omega-3 (omega-6/omega-3) polyunsaturated fatty acids (PUFAs) ratios on bone marrow fatty acid level, ex vivo prostaglandin E2 (PGE2) release, and mineral content of bone in rabbits. MATERIALS/METHODS: For this purpose, weaning and female New Zealand white rabbits were purchased and randomly divided into five groups and offered ad libitum diets containing 70 g/kg of added oil for 100 days. The dietary lipid treatments were formulated to provide the following ratios of omega-6/omega-3 fatty acids: 8.68 soy bean oil (SBO control), 21.75 sesame oil (SO), 0.39 fish oil (FO), 0.63 algae oil (DHA), and 0.68 algae oils (DHA/ARA). DHA and ARA are two types of marine microalgae of the genus Crypthecodinium cohnii. RESULTS: The dietary treatments had significant effects on the bone marrow fatty acids of rabbits. Rabbits fed the FO diet, containing the highest omega-3 PUFA concentration, and those fed the SBO diet showed the highest omega-6 PUFA. On the other hand, a positive correlation was observed between Ex vivo PGE2 level and the omega-6/omega-3 dietary ratio. Significant effects of dietary treatment on femur Ca, P, Mg, and Zn contents were observed in both genders. CONCLUSIONS: Findings of the current study clearly demonstrated that dietary PUFA, particularly omega-6/omega-3 and ARA/EPA ratios are important factors in determining bone marrow fatty acid profile, and this in turn determines the capacity of bone for synthesis of PGE2, thereby reducing bone resorption and improving bone mass during growth.