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AIM:To investigate the effect of neuropathic factor ( NGF) on visual acuity and visual evoked potential ( VEP) in patients with optic nerve contusion.?METHODS:Totally 78 patients ( 78 eyes ) with optic nerve contusion were selected. From January 2013 to June 2016, 39 cases ( 39 eyes ) were divided into observation group and control group respectively according to the random number table method. Prednisone, vitamins and mecobalamin tablets treatment were given to both groups, based on that, the observation group was given NGF treatment, continuous treatment of 2 courses (21d for a course of treatment).?RESULTS: There was no significant difference in visual field defect and visual field sensitivity between the observation group and the control group before treatment (P>0.05). After treatment, the visual field defect degree of the observation group was smaller, the visual field sensitivity was better than that of the control group ( P<0. 05). There was no significant difference in P100 wave latency and P100 wave amplitude between the observation group and the control group before treatment (P>0. 05). After treatment, the P100 wave latency of the observation group was significantly shorter than that of the control group ( P<0. 05 ). The amplitude of P100 wave in the observation group was higher than that in the control group (P<0. 05). After treatment, the visual acuity and visual field sensitivity of the observation group was significantly better than that of the control group (P<0. 05).?CONCLUSION:NGF treatment for optic nerve contusioncan significantly improve the patient's visual acuity, VEP indicators, reduce visual field defects, improve visual field sensitivity.
RESUMEN
AIM:To observe the effect of nerve growth factor treatment on traumatic optic nerve contusion and evaluate its therapeutic effect.METHODS:From January 2012 to January 2016,48 cases (50 eyes) with optic nerve contusion were treated.Retrospective study was carried out and the patients were randomly divided into two groups,treatment group 24 cases of 24 eyes,26 eyes of 24 cases in the control group;the treatment group mainly used mouse nerve growth factor injection 30μg,1 times daily intramuscular injection of medication,6wk,with the application of high pressure hyperbaric oxygen therapy,glucocorticoid and vitamin treatment;the treatment of control group was the same as treatment group,but without the injection of mouse nerve growth factor.Visual acuity,visual evoked potential (VEP) and mean sensitivity (MS),and mean deviation (MD) were examined in all patients at 6wk after the treatment.RESULTS:After treated for 6wk,there were significant differences in the best corrected visual acuity (P＜ 0.05)between the two groups.VEP P100 latency of treatment group was 98.76±6.93ms,amplitude was 5.22±1.64μV,those of the control group were 116.52±8.82ms,4.28± 1.75μV,both significantly different between the two groups (P＜0.05).The differences on MS and MD were significant (P＜0.05).CONCLUSION:The treatment of traumatic optic nerve contusion with nerve growth factor injection has more obvious curative effect.