RESUMEN
Objective To perform the percutaneous Argon-Helium cryoablation on experimental emphysema rabbits Model, in or-der to eveluate the Percutaneous cryoablation of lung volume reduction surgery( LRVS) effectiveness, feasibility and safety.Methods The emphysema model were established on 20 healthy adult new Zealand white rabbits.The lung function and blood gas analysis were measured before and after the emphysema model establishment.After the emphysema model was established, the rabbit were punctured by CT-guided for Argon-helium cryoablation, which was performed for 2 cycles;frozen process for 5 minutes each time;helium active tha-wing, for 2 minutes each time.The result of lung function and blood gas analysis were measured on 1,3,7,14,28 days respectively, meanwhile obtain the corresponding specimens to observe the general morphological and histological changes under light microscopy.Re-sults During the Argon-Helium cryoablation of lung volume reduction surgery, 3 cases of mild intraoperative bleeding ( 15%) and 2 cases of subcutaneous emphysema (10%) happened.compared with emphysema model, lung function and blood gas analysis of the model did not change significantly 1 day post operation(P>0.05), on 3 days and 7 days post operation , lung function and blood gas analysis changed significantly (P<0.05);the lung function and blood gas analysis on 14 days, 28 days post operation have change significantly ( P<0.01) against emphysema model, the best time to improve the result of lung function and blood gas analysis is between 7-14 days. Conclusion Percutaneous cryoablation of lung volume reduction surgery achieve the purpose of effectively destroy the target tissue, sig-nificantly improve the animal model of pulmonary function and blood gas analysis index, with small trauma, fewer complications, higher efficacy and safety.
RESUMEN
Objective To assess the safety and feasibility of CT-guided percutaneous argon-helium cryoablation in the treatment of adrenal tumors.Methods 1 7 patients with adrenal tumors were treated with CT-guided percutaneous argon-helium cryoablation. Three of these patients were retreated second cryoablation three months later due to the lager tumor diameters.Percutaneous tran-scatheter arterial embolization was performed in four patients because of rich blood supply before cryoablation.Continuous arterial blood pressure monitoring was performed in eight pheochromocytoma patients.Results Technical success was achieved in all pa-tients.There were no serious complications.Eight pheochromocytoma patients experienced a significant increase in systolic blood pressure and diastolic pressure when compared with the basic values (P <0.05).There were no enhancement on enhanced CT and/or up-take on FDG PET-CT in the ablated zones during the follow-up period (3-24months).Conclusion It is safety and efficacy of CT-guided percutaneous argon-helium cryoablation for adrenal tumor.It might be initial treatment of choice for the patients who were not suitable for resection.