The relationship between mean daily step counts and pulmonary complications after thoracoscopic lobectomy in elderly patients: A propensity score matching study / 中国胸心血管外科临床杂志

@#Objective     To investigate the relationship between preoperative mean daily step counts and pulmonary complications after thoracoscopic lobectomy in elderly patients. Methods     From 2018 to 2021, the elderly patients with pulmonary complications after thoracoscopic lobectomy were included. A 1∶1 propensity score matching was performed with patients without pulmonary complications. The clinical data were compared between the two groups. Results    Totally, 100 elderly patients with pulmonary complications were enrolled, including 78 males and 22 females, aged 66.4±4.5 years. And 100 patients without pulmonary complications were matched, including 71 males and 29 females aged 66.2±5.0 years. There was no significant difference in the preoperative data between the two groups (P>0.05). Compared to the patients with pulmonary complications, the ICU stay was shorter (8.1±4.4 h vs. 12.9±7.5 h, P<0.001), the first out-of-bed activity time was earlier (8.8±4.5 h vs. 11.2±6.1 h, P=0.002), and the tube incubation time was shorter (19.3±9.2 h vs. 22.5±9.4 h, P=0.015) in the patients wihout pulmonary complications. There was no statistical difference in other perioperative data between the two groups (P>0.05). The mean daily step counts in the pulmonary complications group were significantly less than that in the non-pulmonary complications group (4 745.5±2 190.9 steps vs. 6 821.1± 2 542.0 steps, P<0.001). The daily step counts showed an upward trend for three consecutive days in the two groups, but the difference was not significant. Conclusion     The decline of preoperative mean daily step counts is related to pulmonary complications after thoracoscopic lobectomy in elderly patients. Recording daily step counts can promote preoperative active exercise training for hospitalized patients.

Application of 10-F pig tail drainage tube in single-port thoracoscopic lobectomy / 局解手术学杂志

Objective To explore the effect of 10-F pig tail drainage tube on postoperative incision pain and drainage effect in patients undergoing single-port thoracoscopic lobectomy.Methods A total of 120 patients with lung cancer who underwent single-port thoracoscopic lobectomy admitted to First Affiliated Hospital of Hebei University of Traditional Chinese Medicine were selected and divided into the control group and the observation group,with 60 cases in each group.Patients in the control group were placed a 28-F silicone drainage tube in the posterior mediastinum from the side that deviated from the surgical incision after surgery;and patients in the observation group were placed a 10-F pig tail drainage tube horizontally in the posterior mediastinum at the 7th intercostal space of the posterior axillary line(besides,a 10-F pig tail drainage tube should be placed in the 2nd intercostal space of the midclavicular line if the upper or middle lobes were resected).The pain scores 1,3 and 5 days after operation,healing of surgical incision,extubation time of drainage tube,total drainage volume after opera-tion of patients in the two groups were compared.The incidences of postoperative subcutaneous emphysema,atelectasis and re-intubation of patients in the two groups were recorded.Results There was no statistically significant difference in the total drainage volume,extubation time,incidences of subcutaneous emphysema,atelectasis or re-intubation after operation of patients between the two groups(P>0.05).The postoperative healing of surgical incision of patients in the observation group was better than that in the control group(P<0.05),and the score of postoperative incision pain was significantly lower than that in the control group(P<0.05).Conclusion The application of 10-F pig tail drainage tube after single-port thoracoscopic lobectomy can reduce postoperative incision pain,and ensure the drainage effect of postopera-tive hydrothorax and pneumatosis,without the increase of pulmonary complications.

Effect of transcutaneous acupoint electrical stimulation at Neiguan (PC 6) on general anesthesia under preserving spontaneous breathing in thoracoscopic lobectomy / 中国针灸

OBJECTIVE@#To evaluate the effect of transcutaneous acupoint electrical stimulation (TEAS) at Neiguan (PC 6) on general anesthesia under preserving spontaneous breathing in thoracoscopic lobectomy.@*METHODS@#A total of 66 patients of primary lung cancer undergoing thoracoscopic lobectomy were divided to an observation group (33 cases, 1 case discontinued) and a control group (33 cases). In the observation group, TEAS at Neiguan (PC 6) was used 30 min before anesthesia induction till the end of surgery. The surgery time, maximum value of partial pressure of end-tidal carbon dioxide (PETCO2) and minimum value of oxygen saturation (SpO2) of the two groups were recorded. The dosage of propofol, sufentanil, remifentanil and dexmedetomidine were analyzed. Separately, before induction (T0), at the start of surgery (T1), thoracic exploration (T2) and lobectomy (T3), as well as 30 min (T4) and 60 min (T5) after lobectomy, the mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), serum cortisol (Cor) and norepinephrine (NE) were measured. The time of post anesthesia care unit (PACU) stay, ambulation, flatus, chest drainage and the incidence of nausea and vomiting were compared between the two groups.@*RESULTS@#The maximum value of PETCO2, the dosage of propofol and remifentanil in the observation group were lower than those in the control group (P < 0.05, P < 0.01), the minimum value of SpO2 in the observation group was higher than that of the control group (P < 0.01). At T1-T5, the MAP, HR, serum Cor and NE levels in the observation group were all lower than those in the control group (P < 0.05). The ambulation time, the time for the flatus, chest drainage time, and the incidence of nausea and vomiting in the observation group were all lower than those in the control group (P<0.001, P < 0.01).@*CONCLUSION@#For the general anesthesia under preserving spontaneous breathing in thoracoscopic surgery, TEAS at Neiguan (PC 6) relieves stress response, reduces opioids dosage and promotes postoperative recovery.

Clinical application of preferential manual bronchoplasty in single-port video-assisted thoracoscopic upper lobectomy: A retrospective analysis in a single center / 中国胸心血管外科临床杂志

@#Objective     To explore the safety and feasibility of preferential manual bronchoplasty in single-port video-assisted thoracoscopic surgery (VATS) upper lobectomy. Methods    The clinical data of 457 patients with non-small cell lung cancer who underwent single-port VATS lobectomy in the Department of Thoracic Surgery of Peking University First Hospital from March 2020 to March 2022 were retrospectively analyzed. The patients were divided into a preferential manual bronchoplasty group and a traditional single-port VATS lobectomy group with a 1 : 1 propensity score matching for further research. Results     A total of 204 patients were matched, and there were 102 patients in each group. There were 50 males and 52 females aged 62.2±10.1 years in the preferential bronchoplasty group, and 49 males and 53 females aged 61.2±10.7 years in the traditional single-port VATS group. The preferential bronchoplasty group had shorter surgical time (154.4±37.0 min vs. 221.2±68.9 min, P<0.01), less bleeding (66.5±116.9 mL vs. 288.6±754.5 mL, P=0.02), more lymph node dissection (19.8±7.5 vs. 15.2±4.7, P<0.01), and a lower conversion rate to multi-port or open surgery (2.3% vs. 13.8%, P=0.04) in left upper lobe resection. In the right upper lobe resection surgery, there was no statistical difference in postoperative results between two groups. There was no perioperative death or occurrence of bronchopleural fistula in both groups. Conclusion    Compared with traditional single-port VATS upper lobectomy, preferential bronchoplasty has similar safety and feasibility. In addition, priority bronchoplasty in left upper lobectomy has the advantages of shorter surgical time, less bleeding, more lymph node dissection, and lower conversion rate to multi-port or open surgery.

Correlation Analysis of the Lung Volume Reduction and the Lung Function Loss after the Thoracoscopic Lobectomy / 中国肺癌杂志

BACKGROUND@#To investigate the correlation between the reduction of lung volume and the degree of lung function damage after lobectomy.@*METHODS@#A total of 131 patients (72 males and 59 females) who underwent thoracoscopic lobectomy in the First Affiliated Hospital of Suzhou University from January 2019 to July 2020 (including thoracoscopic resection of left upper lobe, left lower lobe, right upper lobe, right middle lobe and right lower lobe). In order to compare the difference between postoperative pulmonary function and preoperative pulmonary function, the pulmonary function measurements were recorded at 7 days before operation, and 3 months, 6 months and 1 year after operation. Forced expiratory volume in 1 second (FEV1) was used as the main evaluation parameter of pulmonary function. The original lung volume and the remaining lung volume at each stage were calculated by Mimics Research 19.0 software. The correlation between lung volume and lung function was analyzed.@*RESULTS@#FEV1 in postoperative patients was lower than that before operation, and the degree of decline was positively correlated with the resection volume of lung lobes (the maximum value was shown in the left lower lobe group). Significantly, there was no significant difference in the degree of pulmonary function reduction between 3 months, 6 months and 1 year after operation.@*CONCLUSIONS@#The decrease of lung tissue volume after lobectomy is the main reason for the decrease of lung function, especially in the left lower lobe. And 3 months after lobectomy can be selected as the evaluation node of residual lung function.

Thoracic drainage with traditional chest tube versus central venous catheter after video-assisted thoracoscopic lobectomy: A randomized controlled study / 中国胸心血管外科临床杂志

@#Objective    To evaluate the effectiveness and safety of a central venous catheter for thoracic drainage after video-assisted thoracoscopic lobectomy compared with a conventional chest tube. Methods    This study collected 200 patients with lung cancer who underwent thoracoscopic lobectomy and systematic hilar and mediastinal lymph node dissection between January 2018 and September 2019 in our hospital. The patients were randomly divided into two groups, including a group A (left with 28F chest tubes postoperatively) and a group B (left with 12G central venous catheters postoperatively). Patients in both groups were left with 2 chest tubes after upper lobectomy and 1 chest tube after middle or lower lobectomy. Duration and total volume of drainage, length of hospital stay, maximum visual analogue scale score and so forth were compared between the two groups. Results    Finally, 151 patients were included for analysis. There were 73 patients in the group A, including 26 males and 47 females, with an average age of 55.38±9.95 years, and 78 patients in the group B, including 37 males and 41 females, with an average age of 59.86±10.18 years. No statistical  difference was found between the two groups in drainage volume on postoperative day 2, and proportion of prolonged air leaks, hemothorax, chylothorax or drain reinsertion (all P>0.05). There was a statistical difference in drainage volume on postoperative day 1 [200.0 (120.0, 280.0) mL vs. 57.5 (10.0, 157.5) mL, P=0.000], postoperative day 3 [155.0 (100.0, 210.0) mL vs. 150.0 (80.0, 215.0) mL, P=0.023], total volume of drainage [890.0 (597.5, 1 530.0) mL vs. 512.5 (302.5, 786.3) mL, P=0.000], maximum pain score (2.29±0.72 points vs. 2.09±0.51 points, P=0.013) and length of hospital stay [7 (7, 9) d vs. 5 (4, 7) d, P=0.000]. Conclusion    Compared with conventional chest tubes, central venous catheters for chest drainage in patients with lung cancer after thoracoscopic lobectomy shortens the length of hospital stay and reduces postoperative pain.

Safety and efficacy of robotic and thoracoscopic lobectomy in the treatment of early non-small cell lung cancer / 实用医学杂志

Objective To compare the efficacy and safety of robotic lobectomy and thoracoscopic lobectomy in early stage non-small cell lung cancer. Methods From January 2016 to January 2018, 113 patients with early-stage non-small-cell lung cancer who met the inclusion criteria were included in the same surgical group of thoracic and cardiac surgery department of the first affiliated hospital of nanchang university. According to the surgical method, they were randomly divided into robot-assisted thoracoscopic surgery (57 cases) and conventional thoracoscopic surgery (56 cases). Preoperative age (± 5 years) and relevant basic medical history were used to match the patients. The lymph node ascending rate, operative time, preoperative preparation time, intraoperative blood loss, drainage time, postoperative pain score on the second day, postoperative hospitalization time and perioperative complications of the two groups were compared prospectively. Results There was no significant difference in lymph node ascending rate, operation time, pain score on the second day after surgery and lymph node clearance number between the two groups. Intraoperative blood loss, drainage time and postoperative hospitalization time were lower than that of the thoracoscopy group (P < 0.05). The complication rate of the robot group was significantly lower than that in the thoracoscopy group (10.5％ vs. 26.7％, P < 0.05). The preoperative preparation time of the robot group was higher than that of the thoracoscopic group (P < 0.05). Conclusion Robot lobectomy is better and safer in patients with early non-small cell lung cancer than thoracoscopic lobectomy, and can be used in clinical application.

Pulmonary Lobectomy: What are the Benefits of Video-assisted Thoracoscopy?

Introduction: Despite the increasing use of video-assisted thoracoscopic lobectomy, this surgical approach is still controversial in certain aspects. The purpose of this study is to compare the surgical results of video-assisted thoracoscopic pulmonary lobectomy to pulmonary lobectomy via thoracotomy. Materials and Methods: Between 2008 and 2017, 153 patients (n = 89 males) had surgery at the Hospital Universitario Fundación Favaloro. Results: 39/89 patients underwent video-assisted thoracoscopic lobectomy. Patients who had video-assisted thoracoscopy and were diagnosed with lung cancer mostly had stage I tumors (25/39 patients). Postoperative complications and mortality rates were similar in both groups. Video-assisted thoracoscopy patients had a significantly shorter pleural drainage time (4 vs. 3 days, p = 0.004) and a shorter length of hospital stay (6 vs. 4 days of stay, p = 0.03). The number of lymph node stations sampled during surgery was higher in the patients operated via thoracotomy (4 vs. 3.5 lymph node stations, p < 0.001). Conclusion: Video-assisted thoracoscopic lobectomy was at least equivalent to surgery by means of thoracotomy in terms of postoperative complications. The main benefits of the video-assisted thoracoscopy approach were shorter pleural drainage time and length of hospital stay. Special attention should be paid to nodal sampling when the surgery is performed via video-assisted thoracoscopy.

Effect of dexmedetomidine combined with sufentanil on postoperative analgesia in patients undergoing tho-racoscopic lobectomy / 实用医学杂志

Objective To investigate the effect of dexmedetomidine combined with sufentanil on postoper-ative analgesia in patients undergoing thoracoscopic lobectomy. Methods Sixty patients undergoing thoracoscopic lobectomy were randomly divided into the dexmedetomidine group(DS group)and the control group(S group). The two groups were treated with PCIA.The Group DS:dexmedetomidine 2 μg/kg+sufentanil 1.5 μg/kg+ondan-setron 8 mg;and the group S:sufentanil 2 μg/kg+ondansetron 8 mg,in which all drugs were dissolved in 100 mL 0.9 normal saline. Parameters:loading dose 2 mL;infusion speed 2 mL/h;PCA dosage 2 mL each time;lock time:15 min. The mean arterial pressure(MAP),heart rate(HR),resting(VASR)and cough(VASC)VAS score,and Ramsay sedation score were recorded at 2,6,12,24,36 and 48 h after surgery.The number of press analgesic pump,the amount of sufentanil used,the incidence of adverse reactions such as,the nausea and vomit-ing,respiratory depression,bradycardia and so on were recorded within 48 h after operation. Results Compared with the group S,the MAP and HR of patients in the group DS decreased significantly at each time(P < 0.05), the scores of VASR and VASC decreased obviously at 6,12,24 h after surgery(P<0.05),the number of press analgesic pump,the amount of sufentanil used,the incidence of nausea and vomiting decreased obviously within 48 h after operation(P<0.05).Conclusions Dexmedetomidine combined sufentanil administration in PCIA after thoracoscopic lobectomy can obtain satisfactory analgesic effect and more stable hemodynamics,and reduce the dosage of sufentanil,the incidence of nausea and vomiting.

Effect of single-hole thoracoscopic lobectomy on patients with early non-small cell lung cancerr / 临床外科杂志

Objective To explore the effect of single-hole thoracoscopic lobectomy on patients with early non-small cell lung cancer. Methods A total of 100 patients with early non-small cell lung cancer received surgeries in our hospital from Jan 2014 to Jan 2015. They were divided into observation group(single-hole thoracoscopic lobectomy, 50 cases) and control group (three thoracoscopic lobectomy, 50 cases) according to operation modes. The operation data, postoperative recovery situations and complication rate were compared between two groups. Results All patients completed operations successfully and there were no serious complications during operations. There were no significant differences in operation time, numbers of lymph node dissection, tumor recurrence rate and survival rate in one year after operations between the two groups(P＞0.05). The blood loss, length of incision, thoracic drainage, tube time, postoperative hospital stay and VAS scores at the first day after surgery in observation group were lower than those in control group(P＜ 0.05). The complication rate of observation group [ 20.0％ (10/50) ] was lower than that of control group [40.0％ (20/50) ](P＜0.05). Conclusion As for patients suffered from early non-small cell lung cancer, single-hole thoracoscopic lobectomy has advantages of less bleeding, fast recovery and low complication rate.

Application of enhanced recovery after surgery in patients undergoing thoracoscopic lobectomy with pain management / 中国实用护理杂志

Objective To explore the effect of Enhanced Recovery after Surgery in patients undergoing thoracoscopic lobectomy with pain management. Methods A total of 160 patients with lung cancer admitted from September 20 to July 2017 at the Affiliated Chest Hospital of Shanghai Jiaotong University were randomly divided into observation group and control group. The observation group was treated with enhanced recovery care and the control group was treated with routine care. Results The incidence of postoperative complications, hospitalization time and hospitalization decreased, the difference was not statistically significant (P>0.05). The early postoperative ambulation time, postoperative exhaust time, postoperative nausea and vomiting, postoperative pain intensity at 6h, postoperative pain intensity at 12 h, postoperative pain intensity at 24 h and postoperative pain intensity at 48 h were (18.35 ± 7.18) h, 28.75％,(1.17 ± 0.84) points, (1.79 ± 1.36) points, (2.45 ± 1.12) points and (2.14 ± 1.26) points in research group,(28.11 ± 9.07) h, (36.35 ± 16.95) h, 45.00％(36/80), (1.91 ± 0.88) points, (3.05 ± 1.33) points, (4.20 ± 1.31) points and (3.89 ± 1.20) points in controlled group. There was significant difference between the two groups (t=-7.36-78.34,χ2=4.54, P<0.05). Conclusions The idea of Enhanced Recovery after Surgery for thoracoscopic lobectomy has a good clinical effect. It can reduce the perioperative stress, shorten the hospital stay and reduce the hospital cost, and have the clinical value.

Effect of periopusside administration of ambroxol combined with psychological intervention on patients with lung cancer after thoracoscopic lobectomy / 中国生化药物杂志

Objective To investigate the effect of perindox administration combined with psychological intervention on patients with lung cancer after thoracoscopic lobectomy.Methods Fifty patients with lung cancer underwent thoracoscopic lobectomy from November 2015 to November 2016 in our hospital were randomly divided into experimental group and experimental group according to the time of hospitalization.Control group, 25 cases.The rats in the experimental group were treated with ambroxol hydrochloride(600 mg/d)from the day of operation to the postoperative 3d administration.The control group was treated with the same volume of saline.At the same time, the experimental group was treated with psychological intervention and the necessary psychological guidance was carried out.The data were collected and compared with the two groups before and after the general information, intraoperative conditions, lung function before and after surgery and blood gas analysis Results , mechanical ventilation time, early postoperative complications, postoperative hospital stay and treatment costs.ResultsThere were no cases of death in the perioperative period.Compared with the control group, the total incidence of postoperative complications was not significant, but the pulmonary complications were significantly reduced, only 1 case and 9 cases in the control group The In addition, the postoperative mechanical ventilation, ICU time, postoperative hospital stay, total treatment costs, the difference between the two groups was significant, the data were statistically significant(P<0.05).Conclusion The patients with lung cancer underwent thoracoscopic lobectomy with high dose intravenous ambroxol hydrochloride in the perioperative period can greatly improve the postoperative pulmonary function and reduce the postoperative complications, and effectively reduce the postoperative hospitalization Time, the material pressure on the patient is further reduced.

Use of sugammadex in lung cancer patients undergoing video-assisted thoracoscopic lobectomy / 대한마취과학회지

BACKGROUND: This study aimed to retrospectively evaluate the use of sugammadex in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy. METHODS: Data were obtained from medical record review of patients who underwent VATS lobectomy from January 2013 to November 2014. Fifty patients were divided into two groups: the sugammadex group (group S, n = 19) was administered sugammadex 2 mg/kg, while the pyridostigmine group (group P, n = 31) received pyridostigmine 20 mg with glycopyrrolate 0.2 mg or atropine 0.5 mg. The primary endpoint measure was the overall incidence of postoperative pulmonary complications including prolonged air leak, pneumonia, and atelectasis. The secondary endpoint measures were the length of postoperative hospital stay and duration of chest tube insertion. RESULTS: The overall incidence of postoperative pulmonary complications in patients in group S was significantly lower compared with that of group P (5 [26.3%] vs. 17 [54.8%]; P = 0.049). Also, the durations of chest tube insertion (5.0 [4.0–7.0] vs. 7.0 [6.0–8.0] days; P = 0.014) and postoperative hospital stay (8.0 [8.0–10.0] vs. 10.0 [9.0–11.0] days; P = 0.019) were shorter in group S compared with group P. Administration of sugammadex was associated reduced with postoperative pulmonary complications (OR: 0.22; 95% CI: 0.05–0.87; P = 0.031). CONCLUSIONS: The use of sugammadex, compared with pyridostigmine, showed a significantly reduced overall incidence of postoperative pulmonary complications and decreased duration of chest tube use and postoperative hospital stay in patients undergoing VATS lobectomy, suggesting that sugammadex might be helpful in improving clinical outcomes in such patients.

Effect of periopusside administration of ambroxol combined with psychological intervention on patients with lung cancer after thoracoscopic lobectomy / 中国生化药物杂志

Objective To study the effect of the combined psychological intervention of ambroxol on the patients with lung cancer after thoracoscopic lobectomy. Methods January 2015 to December 2016, Beijing Jian Gong Hospital under thoracoscope lung resection of 64 cases of patients with lung cancer, the control group treated with saline 600 mL/d, experimental group implementation of ammonia bromine line on postoperative 3 days for the patient on the day of surgery until given intravenous 600 mL/d hydrochloric acid ammonia bromine injection combined psychological intervention treatment. Results There were no deaths in the perioperative period, but the lung complications in the experimental group were significantly lower than those in the control group. There were significant differences in mechanical ventilation, ICU time, postoperative hospital stay, and treatment cost after surgery (P < 0.05). Conclusion For patients with lung cancer in perioperative implementation under the thoracoscope lung resection and intravenous hydrochloric acid ammonia bromine joint line comments fluid psychological intervention treatment, effectively improve the patients' lung function and significantly lower the incidence of complications, shorten the patient's hospital stay, reduce the economic burden, and can be applied clinically.

Influencing factors of postoperation fast-track recovery in patients with thoracoscopic lobectomy / 中国实用护理杂志

Objective To explore influencing factors of postoperation fast-track recovery in patients with thoracoscopic lobectomy and provide support for the concept of fast track surgery in clinically application. Methods A total of 129 patients who underwent thoracoscopic lobectomy were selected and questionnaire were adopted for survey between January 2015 and September 2015. Univariate analysis and multivariable logistic regression analysis were used to screen influencing factors of postoperation fast-track recovery. Results Univariate analysis showed that the influnecing factors of postoperation fast-track recovery in patients with thoracoscopic lobectomy were closely related to the age, combined basic disease or not,smoking index,preoperative smoking cessation time,preoperative pulmonary function training or not,systematic health education or not,postoperative wound pain,early postoperative ambulation or not,postoperative chest exercises in time or not (t=2.880,χ2=0.219-33.224, P<0.01 or 0.05). Multivariable logistic regression analysis showed that systematic health education or not, postoperative wound pain,preoperative pulmonary function training or not,postoperative chest exercises in time or not,combined basic disease or not,smoking index,and quit smoking more than two weeks or not were the independent risk factors. Conclusions For the patients with thoracoscopic lobectomy, preoperative condition and postoperative condition in the early should be assessed in time. Controlling the pain effectively,giving reasonable guidance of preoperative pulmonary function exercise,strengthening the respiratory tract management,systematic health education,improving the ward environment,high quality of social support and other diversified services could accelerate the recovery of the postoperative patients.

The study of the correlation between prognosis and the sequence of vessel interruption during thoracoscopic lobectomy for early stage non-small cell lung cancer / 中华胸心血管外科杂志

Objective To study the correlation between prognosis and the sequence of vessel interruption during thoracoscopic lobectomy for early stage non-small cell lung cancer.Methods Retrospective analysis of the 1 134 cases underwent lobectomy between September 2006 and October 2012 was conducted.There were 277 cases underwent completely thoracoscopic lobectomy and confirmed as stage Ⅰ-Ⅱ non-small cell lung cancer by pathology.The cases were divided into three groups according to the vessel interruption sequence:pulmonary vein ligated first(Group V) 152 cases,pulmonary artery ligated first (Group A) 76 cases,and artery-vein-artery group(Group M) 49 cases.The preoperative condition,operative factors and the prognosis of the three groups were reviewed.All of the data for statistical analysis,count data by chi-square test.Measurement data using t test,Kaplan-Meier method applied survival analysis,Log-rank test and Cox regression model analysis for single factor and multiple factors.Results The groups were similar in age,sex,smoking history,pulmonary infection history,main comorbidity,malignant history,diameter,tumor maker and preoperative lung function.The blood loss during the operation is 109.9 ml in Group A,which is significantly less than Group V (157.5 ml),and Group M had the median blood loss 123.7 ml (P =0.027).The length of operation and postoperative complications were similar among the three groups.The recurrent conditions were also similar among the three groups,which were mostly distant metastasis.There was no significant difference statistically in disease free survival(DFS) and overall survival(OS) among the three groups.Conclusion Ligating the pulmonary artery first could decrease the blood loss during completely thoracoscopic lobectomy for stage Ⅰ-Ⅱ non-small cell lung cancer.But it did not have any influence on the surgical difficulty and postoperative complications.The sequence of vessel interruption during lobectomy by thoracoscopic surgery did not have difference effect on the prognosis of lung cancer.

Comparison of curative effects of lobectomy between C-VATS and thoracotomy in aged patients with lung cancer / 吉林大学学报(医学版)

Objective To investigate the difference of curative effects between the complete video assisted thoracic surgery (C-VATS)and traditional open surgery in the treatment of elderly patients with lung cancer,and to clarify the specially curative effect of C-VATS.Methods 80 patients with lung cancer without diabetes mellitus,chronic brouchitis and heart diseases aged over 65 years were enrolled in the study.They were divided into C-VATS group and open surgery for lobectomy (OPEN)group (n=40)according their wishes.The operation time,number of lymph nodes removed,amount of intraoperative blood loss,postoperative thoracic drainage,chest tube duration, postoperative hospitalized time, postoperative pain degree, incidence of postoperative complications, preoperative and postoperative sedentary heart rate (HR)of the patients in two groups were compared.Results The operation time in C-VATS group(193.12 min±59.06 min)was longer than that in OPEN group(167.17 min±54.01 min) (P0.05).The postoperative pain degree in C-VATS group(2.54 ± 0.12)was lower than that in OPEN group(4.61 ± 0.10)(P0.05).The postoperative sedentary HR in C-VATS group and OPEN group were significantly higher than preoperative;the postoperative sedentary HR recovered to the preoperative level 3 d after operation in C-VATS group and it recovered to the preoperative level 7 d after operation in OPEN group. Conclusion Compared with traditional open thoracic surgery, C-VATS owns the characteristics such as less trauma, less pain, less hospital stay and better postoperative recovery in the aged patients with lung cancer.

Application of Ultrasonic Positioning in Thoracoscopic Lobectomy / 昆明医科大学学报

Objective To investigate the application value and effect of lung vascular and lesion positioning guided by Doppler ultrasound in the operation of thoracoscopic lobectomy. Methods Thirty cases of experimental pigs were randomly divided into A, B and C three groups. The group A was operated by conventional thoracoscope for upper right lobectomy, and group B was operated by thoracoscope for upper right lobectomy which guided by Doppler ultrasound cavity prober. Then, the operation time, blood loss and materials costs were compared between the two groups. The group C was used to establish the model of lung cancer and CT scanning was used to indicate the lung lesions. During operation, lesions were positioned by Doppler ultrasound and wedge resections were performed under thoracoscope. Then, the pulmonary lobectomy guided by ultrasound and mediastinal lymph nodes dissection were performed. At last, the coincidence rate of intraoperative ultrasound and CT location was analyzed statistically. Results There were significant differences in operation time between Groups A and B ( 0.05) . In group C, lesion location positioning guided by ultrasound during the operation was completely consistent with guided by CT before the operation. No significant differences in the lesion diameter were observed between ultrasound and CT methods ( > 0.05) . Conclusion With the application of Doppler ultrasound, the invisible and untouchable blood vessel can become visible and can be positioned in precise to shorten the time of thoracoscopic lobectomy. In addition, the accurate positioning of tiny lesions in the lung can solve the problem of lung small lesion positioning which is difficult in the operation under thoracoscope. Therefore, it can be promoted in clinical applications in a wide range.

Analysis of complicated procedure of completely thoracoscopic lobectomy / 中华胸心血管外科杂志

Objective Summarize 58 cases with complicated primary lung cancer that accepted completely thoracoscopic lobectomy procedure in People's Hospital of Peking University,to evaluate the procedure of completely thoracoscopic lobectomy in these complicated cases.Methods Between Sep 2006 and Jun 2011,58 cases accepted completely thoracoscopic lobetomy were reviewed.34 male,24 female,aged (59.2 ± 11.4) years.The maximal diameter of solid tumors was(5.50 ± 2.92 )cm.The complicated condition including ①maximal diameter of solid tumor ≥5 cm ; ② Compound lobectomy; ③ post newadjuvant chemotherapy; ④ tummor invased portion of chest wall.The main procedure including three main components:①multiple devices co-operation through a single incision; ② Separate the fissure liketunnel style ; ③ cutting off bronchial artery priority to all step of lobectomy.Results All procedures were carried out smoothly with no death or serious complication.The average surgical duration was( 215.6 ± 60.9 ) min,and average blood loss was ( 271.0 ± 188.3 ) ml.The median postoperative chest tube drainage duration was(8.0 ± 4.7 ) d,and median postoperative hospital stay was ( 11.3 ± 5.9 ) d.There were 14 cases (24.1％ ) of conversion to open thoracotomy and 7 cases ( 12.1％ ) of complications.① There were 34 cases that maximal diameter of solid tumor was ≥5 cm,The average maximal diameter of tumors was( 6.7 ± 2.3) cm,The average surgical duration was( 206.6 ± 49.3 ) min,and average blood loss was (277.1 ± 194.4 ) ml.The median postoperative chest tube drainage duration was (8.3 ± 4.2 ) d,and median postoperative hospital stay was ( 11.9 ± 6.2 ) d.There were 8 cases (23.5％) of conversion to open thoracotomy and 6 cases ( 17.6 ％ ) complications; ②There were 16 cases of Compound lobectomy,The average maximal diameter of tumors was(4.2 ± 3.4 ) cm,The average surgical duration was (213.8 ± 70.0 )min,and average blood loss was(235.6 ± 139.2 ) ml.The median postoperative chest tube drainage duration was( 8.6 ± 6.3 )d,and median postoperative hospital stay was( 12.4 ±6.0) d.There were 4 cases (25％) of conversion to open thoracotomy and 2 cases ( 12.5 ％ ) complications;③There were 5 cases of VATs lobectomy that post newadjuvant chemotherapy,The average maximal diameter of tumors was(3.1 ±0.8) cm,The average surgical duration was(226.0 ±36.3 ) min,and average blood loss was(246.0 ± 219.8) ml.The median postoperative chest tube drainage duration was( 5.6 ± 1.1 ) d,and median postoperative hospital stay was( 7.4 ± 0.5 ) d.There were 2 cases (40％) of conversion to open thoracotomy and no complications; ④There were 3 cases that tumor invased portion of chest wall.The average maximal diameter of tumors was(3.0 ± 2.0)cm,The average surgical duration was(310.0 ± 105.4) min,and average blood loss was(433.3 ± 305.5 ) ml.The median postoperative chest tube drainage duration was( 5.6 ± 2.1 ) d,and median postoperative hospital stay was ( 6.6 ± 2.1 ) d.There were no conversion to open thoracotomy and complications.Conclusion As the skills and experience of thoracoscopic lobectomy improving,Some relative complexity cases and relative contraindications may become relative indications for completely thoracoscopic procedure.As long as the methods and technical processes used properly,these complicated cases of primary lung cancer does not prolong the operation time,not increase bleeding and interfere the reeovery of patients.

Video-assisted Thoracoscopic Lobectomy for Pulmonary Benign Diseases / 中国微创外科杂志

Objective To evaluate the safety and efficacy of thoracoscopic lobectomy for pulmonary benign diseases.Methods Between July 2002 and September 2007,35 cases with pulmonary benign diseases underwent thoracoscopic lobectomy in our hospital.Of the patients,video-assisted thoracoscopic lobectomy was performed on 12 cases,and totally endoscopic lobectomy was carried out in 23.Results The operation was completed in all of the cases except in one who was converted to open surgery because of massive hemorrhage.In this series,no peri-operational death occurred,however,complications occurred in 3 cases(morbidity rate: 8.6%),including 2 cases of persistent air leak and 1 case of pneumonia.The mean duration of chest tube drainage was 3.6 days(2 to 7 days),and average hospital stay after operation was 7.7 days(2 to 14 days).Postoperative pathological diagnosis included bronchiectasis in 15 patients,pulmonary inflammatory pseudo-tumor in 6,tuberculosis in 5,fungal infection in 5,pulmonary sequestration in 2,and bronchogenic cyst in 2.Conclusions Thoracoscopic lobectomy is safe and effective for pulmonary benign disease.