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Frontiers of Medicine ; (4): 497-508, 2018.
Artículo en Inglés | WPRIM | ID: wpr-772710

RESUMEN

Viral infections cause at least 10%-15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.


Asunto(s)
Humanos , Antivirales , Usos Terapéuticos , Sistemas CRISPR-Cas , Carcinoma , Genética , Terapéutica , Virología , Edición Génica , Predisposición Genética a la Enfermedad , Terapia Genética , Métodos , Infecciones Tumorales por Virus
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