Asunto(s)
Anticuerpos/análisis , Anticoagulantes/efectos adversos , Antitrombinas/uso terapéutico , Bencimidazoles/uso terapéutico , Sulfatos de Condroitina/uso terapéutico , Dermatán Sulfato/uso terapéutico , Fibrinolíticos/uso terapéutico , Heparina/efectos adversos , Heparina/inmunología , Heparitina Sulfato/uso terapéutico , Hirudinas , Fragmentos de Péptidos/uso terapéutico , Ácidos Pipecólicos/uso terapéutico , Inhibidores de Agregación Plaquetaria/uso terapéutico , Polisacáridos/uso terapéutico , Piridinas/uso terapéutico , Proteínas Recombinantes/uso terapéutico , Trombina/antagonistas & inhibidores , Trombocitopenia/inducido químicamente , Trombocitopenia/terapiaAsunto(s)
Anticoagulantes/uso terapéutico , Antitrombinas/uso terapéutico , Bencimidazoles/uso terapéutico , Humanos , Morfolinas/uso terapéutico , Ácidos Pipecólicos/uso terapéutico , Pirazoles/uso terapéutico , Piridonas/uso terapéutico , Tiofenos/uso terapéutico , Tromboembolia Venosa/prevención & control , beta-Alanina/análogos & derivados , beta-Alanina/uso terapéuticoRESUMEN
The concept of neuroprotection relies on the principle that delayed neuronal injury occurs after ischemia. The phenomenon of the "ischemic cascade" has been described, and each step along this cascade provides a target for therapeutic intervention. A wide variety of drugs have been studied in humans. Ten classes of neuroprotective agents have reached phase III efficacy trials but have shown mixed results. They included calcium channel antagonists, NMDA receptor antagonists, lubeluzole, CDP-choline, the free radical scavenger tirilazad and ebselen, enlimomab, GABA agonist clomethiazole, the sodium channel antagonist fosphenytoin, magnesium, glycine site antagonist GV150526 and piracetam. Furthermore, the mechanisms that underlie the development of focal ischemic injury continue to be discovered, opening new therapeutic perspective for neuroprotection that might clinically be applicable in the future.