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1.
Rev. Soc. Bras. Med. Trop ; 51(4): 546-549, July-Aug. 2018. graf
Artículo en Inglés | LILACS | ID: biblio-1041472

RESUMEN

Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.


Asunto(s)
Animales , Femenino , Esquistosomiasis mansoni/inmunología , Anticuerpos Antihelmínticos/inmunología , Interleucina-2/inmunología , Interleucina-10/inmunología , Linfocitos T Reguladores/inmunología , Animales Lactantes/inmunología , Ovalbúmina/inmunología , Citometría de Flujo , Animales Lactantes/parasitología , Ratones
2.
Mem. Inst. Oswaldo Cruz ; 111(2): 83-92, Feb. 2016. tab, graf
Artículo en Inglés | LILACS | ID: lil-772619

RESUMEN

Schistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. We evaluate the immunity to parasite antigens and ovalbumin (OA) in adult mice born/suckled by schistosomotic mothers. Newborns were divided into: born (BIM), suckled (SIM) or born/suckled (BSIM) in schistosomotic mothers, and animals from noninfected mothers (control). When adults, the mice were infected and compared the hepatic granuloma size and cellularity. Some animals were OA + adjuvant immunised. We evaluated hypersensitivity reactions (HR), antibodies levels (IgG1/IgG2a) anti-soluble egg antigen and anti-soluble worm antigen preparation, and anti-OA, cytokine production, and CD4+FoxP3+T-cells by splenocytes. Compared to control group, BIM mice showed a greater quantity of granulomas and collagen deposition, whereas SIM and BSIM presented smaller granulomas. BSIM group exhibited the lowest levels of anti-parasite antibodies. For anti-OA immunity, immediate HR was suppressed in all groups, with greater intensity in SIM mice accompanied of the remarkable level of basal CD4+FoxP3+T-cells. BIM and SIM groups produced less interleukin (IL)-4 and interferon (IFN)-g. In BSIM, there was higher production of IL-10 and IFN-g, but lower levels of IL-4 and CD4+FoxP3+T-cells. Thus, pregnancy in schistosomotic mothers intensified hepatic fibrosis, whereas breastfeeding diminished granulomas in descendants. Separately, pregnancy and breastfeeding could suppress heterologous immunity; however, when combined, the responses could be partially restored in infected descendants.


Asunto(s)
Animales , Femenino , Masculino , Ratones , Embarazo , Animales Lactantes/inmunología , Anticuerpos Antihelmínticos/inmunología , Granuloma de Cuerpo Extraño/inmunología , Inmunidad Humoral/fisiología , Parasitosis Hepáticas/inmunología , Esquistosomiasis mansoni/inmunología , Adyuvantes Inmunológicos , Animales Recién Nacidos , Animales Lactantes/parasitología , /parasitología , Cercarias/inmunología , Ensayo de Inmunoadsorción Enzimática , Citometría de Flujo , Factores de Transcripción Forkhead/sangre , Granuloma de Cuerpo Extraño/parasitología , Granuloma de Cuerpo Extraño/patología , Inmunidad Heteróloga/fisiología , Inmunoglobulina G/sangre , Interferón gamma/sangre , /sangre , /sangre , Cirrosis Hepática/inmunología , Cirrosis Hepática/parasitología , Parasitosis Hepáticas/patología , Madres , Ovalbúmina/inmunología , Schistosoma mansoni/inmunología , Bazo/inmunología , Bazo/patología
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