Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Añadir filtros








Intervalo de año
1.
J Environ Biol ; 2005 Apr; 26(2): 191-5
Artículo en Inglés | IMSEAR | ID: sea-113773

RESUMEN

The activities of phosphatases and transaminases were studied in muscle and liver of the fresh water fish, Oreochromis mossambicus on exposure to different sublethal concentrations (0.25, 0.5, 0.75 and 1 mgl(-1)) of cartap hydrochloride (insecticidal derivative from marine polycheate) for 96 h. There was an overall decrease in phosphatases and transaminases activity in muscle and liver of the fish subjected to cartap hydrochloride.


Asunto(s)
Fosfatasa Ácida/metabolismo , Alanina Transaminasa/antagonistas & inhibidores , Fosfatasa Alcalina/metabolismo , Animales , Aspartato Aminotransferasas/antagonistas & inhibidores , Hígado/efectos de los fármacos , Músculos/efectos de los fármacos , Poliquetos/química , Tiocarbamatos/toxicidad , Tilapia/metabolismo
2.
Indian J Physiol Pharmacol ; 2003 Oct; 47(4): 435-40
Artículo en Inglés | IMSEAR | ID: sea-108170

RESUMEN

The effect of Himoliv (HV) was evaluated in carbon tetrachloride or paracetamol induced hepatotoxicity in rats. Liver necrosis was produced by administering single dose of either carbon tetrachloride (CCl4, 1 ml/kg, 50% v/v with olive oil, s.c.) or paracetamol (PC, 1 g/kg, p.o.). The liver damage was evidenced by elevated levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosphatase (ALP) and hepatic thiobarbituric acid reacting substances (TBARS) and superoxide dismutase (SOD). HV pretreatment (0.5 and 1.0 ml/kg, p.o.) significantly (P < 0.001) reduced CCl4 or PC-induced elevations of the levels of SGOT, SGPT, ALP and TBARS, while the reduced concentration of SOD due to CCl4 or PC was reversed. Silymarin (25 mg/ kg, p.o.), a known hepatoprotective drug showed similar results.


Asunto(s)
Acetaminofén/antagonistas & inhibidores , Alanina Transaminasa/antagonistas & inhibidores , Fosfatasa Alcalina/antagonistas & inhibidores , Animales , Aspartato Aminotransferasas/antagonistas & inhibidores , Tetracloruro de Carbono/antagonistas & inhibidores , Femenino , Hígado/efectos de los fármacos , Hepatopatías/inducido químicamente , Masculino , Preparaciones de Plantas/farmacología , Plantas Medicinales/química , Ratas , Ratas Wistar
3.
Indian J Physiol Pharmacol ; 1987 Jan-Mar; 31(1): 12-8
Artículo en Inglés | IMSEAR | ID: sea-107405

RESUMEN

Urinary aspartate-transaminase activity in the whole urine was found to be mean +/- S.D. = 8.46 +/- 0.69 l.U/l when measured immediately after urine collection. About 50% loss in enzyme activity was observed after 18 hours dialysis. An overall 176% increase in enzyme activity followed by Sephadex G-25 (fine) whole urine fractionation and a highly significant (P less than .001) partial inhibition by earlier Sephadex fractions and maximum inhibition by earlier Sephadex fractions and maximum inhibition of enzyme by fraction 7 have suggested the presence of both high and low molecular weight urinary inhibitors of aspartate-transaminase. Urea and ammonia presence and inhibitor activity in fraction 6 to 8 bear a close parallelism; both the substances produced 31% inhibition of partially purified goat liver GOT at concentrations approximating normal human urine. Therefore, low enzyme activity and its substantial loss in the whole urine and during dialysis may be due to the concomitant inhibitory effects of urea, ammonia and unidentified nature of high molecular weight substance(s). The present method may be effective in separating inhibitors and overcoming the disadvantages of dialysis in determining true urinary aspartate-transaminase activity.


Asunto(s)
Adulto , Amoníaco/orina , Aspartato Aminotransferasas/antagonistas & inhibidores , Cromatografía en Gel , Inhibidores Enzimáticos/orina , Humanos , Masculino , Peso Molecular , Valores de Referencia , Urea/orina
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA