1.
Chinese Journal of Contemporary Pediatrics
;
(12): 217-222, 2023.
Artículo
en Chino
| WPRIM
| ID: wpr-971063
RESUMEN
The mutations of TTN gene that encodes titin are the most common mutation type among the genetic causes of dilated cardiomyopathy (DCM). This article reviews the worldwide studies on potential molecular pathogenesis (transcription, post-translational modification, etc.), clinical phenotypes, and gene therapies of pediatric DCM caused by TTN mutations, with the hope of providing a reference for the precision treatment of pediatric DCM caused by TTN mutations.