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Indian J Dermatol Venereol Leprol ; 2015 Jan-Feb; 81(1): 43-45
Artículo en Inglés | IMSEAR | ID: sea-154971

RESUMEN

Allopurinol, a drug commonly used for treating gout and hyperuricemia, is a frequent cause of drug eruptions. Recent investigations suggest that HLA‑B*5801 allele is a very strong marker for allopurinol‑induced cutaneous adverse drug reactions (cADRs). In this article we report two cases of allopurinol‑induced drug eruptions in patients carrying the HLA‑B*5801 allele and review the literature on the association between HLA‑B*5801 and allopurinol‑induced cADRs based on a MEDLINE and PubMed search.


Asunto(s)
Anciano , Alopurinol/efectos adversos , Alopurinol/uso terapéutico , Erupciones por Medicamentos/etiología , Erupciones por Medicamentos/genética , Antígenos HLA-B/clasificación , Antígenos HLA-B/genética , Masculino , Persona de Mediana Edad , MEDLINE , PubMed
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