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Journal of Southern Medical University ; (12): 1399-1405, 2020.
Artículo en Chino | WPRIM | ID: wpr-880776

RESUMEN

OBJECTIVE@#To investigate the protective effect of arctiin with anti-inflammatory bioactivity against triptolide-induced nephrotoxicity in rats and explore the underlying mechanism.@*METHODS@#Forty SD rats were divided into 4 groups for gastric lavage of normal saline, arctiin (500 mg/kg), triptolide (500 μg/kg), or both arctiin (500 mg/kg) and triptolide (500 μg/kg). Blood samples were collected for analysis of biochemical renal parameters, and the renal tissues were harvested for determining the kidney index and for pathological evaluation with HE staining. In the @*RESULTS@#In SD rats, arctiin significantly antagonized triptolide-induced elevation of BUN, Scr and kidney index (@*CONCLUSIONS@#Arctiin can protect the kidney from triptolide-induced damages in rats possibly through the anti-inflammatory pathway.


Asunto(s)
Animales , Ratas , Antiinflamatorios , Diterpenos/toxicidad , Compuestos Epoxi/toxicidad , Furanos , Glucósidos , Riñón/efectos de los fármacos , Fenantrenos/toxicidad , Ratas Sprague-Dawley
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