Efficacy of Peracetic Acid (EndoPA®) for Disinfection of Endoscopes / 대한소화기학회지

BACKGROUND/AIMS: We aimed to investigate the efficacy of peracetic acid (EndoPA®; Firson Co., Ltd., Cheonan, Korea) in disinfecting endoscopes. METHODS: We prospectively investigated the gastroscopes (Part I) utilized in 100 gastroscopic examinations and colonoscopes (Part II) utilized in 30 colonoscopic examinations after disinfecting them with 0.2% peracetic acid (EndoPA®; Firson Co., Ltd.). These instruments had been collected consecutively throughout the study period. We reprocessed and disinfected the endoscopes according to the guidelines for cleaning and disinfecting gastrointestinal endoscopes laid down by the Korean Society of Gastrointestinal Endoscopy in 2017. Three culture samples were obtained from each examination, based on different sampling methods. The primary outcome was a positive culture rate. RESULTS: In Part I of our study, two of 300 samples were positive. The culture positive rate after disinfection was 0.7% (2/300). The culture positive rate was not significantly different based on the exposure time to EndoPA® or the age of the scopes (p=0.7 or 0.2, respectively). In Part II of our study, all samples (n=90) were negative. CONCLUSIONS: We conclude that 0.2% peracetic acid (EndoPA®) appears to be a good disinfectant for both gastroscopes and colonoscopes.

Pancreatic Necrosectomy through Sinus Tract Endoscopy

BACKGROUND/AIMS: Direct endoscopic pancreatic necrosectomy is increasingly being utilized to treat infected or symptomatic walled-off necrosis (WON) located close to the stomach or duodenum. Laterally-placed WON has traditionally been treated surgically. We evaluated a less utilized technique of sinus tract endoscopy (STE) for symptomatic laterally-placed WON. METHODS: Two hundred seventy-six patients with acute pancreatitis admitted in our hospital, 32 had symptomatic or infected WON requiring intervention. Of the 12 patients with laterally placed WON, 10 were treated by STE. STE was performed with a standard adult gastroscope passed through a percutaneous tract created by the placement of a 32-Fr drain. RESULTS: Ten patients (7 males; mean age, 43.8 years) underwent STE. Mean number of sessions was 2.3 (range, 1–4), with mean time of 70 minutes for each session (range, 15–70 minutes). While 9 patients had complete success, 1 patient had fever and chose to undergo surgery. Two patients developed pneumoperitoneum, which was treated conservatively. There was no mortality, cutaneous fistula, or recurrence during follow-up. CONCLUSIONS: Laterally placed WON can be successfully managed by STE performed through a percutaneously placed drain. Details of the technique and end-points of STE require further evaluation.

ERCP and Direct Cholangioscopy with Gastroscope in Patients with Ectopic Opening of the Bile Duct into the Duodenal Bulb: A Report of 3 Cases / 대한췌담도학회지

Ectopic openings of the common bile duct into the duodenal bulb, which are associated with biliary tract disease or recurrent/refractory duodenal ulcers, are rare. We report three such cases, all of which were documented with gastroscope, and two of which were managed with endoscopic retrograde cholangiopancreatography (ERCP) via gastroscope. We suggest that ERCP can be performed with gastroscope, since it may offer a better working position in certain cases.

Is the Double Channel Gastroscope Useful in Endoscopic Mucosal Resection for Large Sessile Colon Polyps?

No abstract available.

Use of a Double-Channel Gastroscope Reduces Procedural Time in Large Left-Sided Colonic Endoscopic Mucosal Resections

BACKGROUND/AIMS: Endoscopic mucosal resection (EMR) of large colorectal lesions is associated with increased procedural time. The objective of this study was to evaluate the effect of double-channel gastroscope (DCG) use on the procedural time of EMRs in the rectosigmoid area. METHODS: All EMRs for sessile or flat rectosigmoid lesions > or =2 cm performed between July 2011 and September 2012 were retrospectively analyzed. RESULTS: There were 55 lesions > or =2 cm in the rectosigmoid area in 55 patients, of which 26 were removed by EMR using a DCG (DC group) and 29 by using an ordinary colonoscope or gastroscope (OS group). The mean size of the removed polyps, morphology, adverse effects, and other parameters were similar between the two groups. The mean procedural time was significantly lower in the DC group than in the OS group (24.4+/-18.3 minutes vs. 36.3+/-24.4 minutes, p=0.015). Moreover, in a subgroup of patients with polyps >40 mm, the statistical difference in the mean procedural time between the DC and OS groups was even more pronounced (33+/-21 minutes vs. 58.7+/-20.6 minutes, p=0.004). CONCLUSIONS: Our data suggest that the use of a DCG in the resection of large nonpedunculated rectosigmoid lesions significantly reduces the procedural time.

Usefulness of Gastroscope in Patients with Incomplete Colonoscopy

BACKGROUND/AIMS: Conventional colonoscopy is limited in some patients with several causes, such as fixed angulation, extensive loop or adhesion. Therefore, small-caliber scopes are considered alternatives to unsuccessful conventional colonoscopy. The aim of this study is to evaluate the usefulness of gastroscope in patients with unsuccessful colonoscopy. METHODS: From May 2008 to April 2009, a total of 2,548 colonoscopies were performed in Wonkwang University Hospital. The gastroscope was used subsequently when conventional colonoscopy failed. RESULTS: There were 27 cases (1.06%) of unsuccessful colonoscopy. The causes of failure were assessed as fixed angulation of the sigmoid colon (59.2%, 16/27), excessive looping (14.8%, 4/27), stricture (14.8%, 4/27), sigmoid diverticulosis (7.4%, 2/27), and adhesion of transverse colon (3.7%, 1/27). The average time of intubation to cecum with the gastroscope was 7 minutes and 28 seconds (range, 2 to 20 minutes). With the gastroscope, 77.8% (21/27) were intubated to the cecum. The pain score of gastroscope was reduced, as compared with that of conventional colonoscopy (4.95 vs. 5.94, P<0.001). CONCLUSIONS: Gastroscope would be a useful alternative tool in patients with unsuccessful colonoscopy.

A New Technique Using Ultra-slim Endoscopy for High-Grade Crohn's Stricture

Crohn's disease (CD) is a chronic inflammatory bowel disease of unknown etiology. Most patients with CD will eventually develop a stricturing or penetrating complication. Colonoscopic findings may predict the clinical course in patients with CD. Moreover, since CD patients are at increased risk for developing dysplasia and colorectal cancer, surveillance colonoscopy is necessary for the detection of malignancies. We describe here a CD patient with a high-grade anorectal stricture who successfully underwent a total colon examination with an ultra-slim upper endoscope after an insertion failure with a standard colonoscope and gastroscope.

Unsedated Colonoscopy and the Water Method for Minimizing Discomfort in the Unsedated Patients

A decade ago, failure of cecal intubation due to pain in ~20% of scheduled unsedated patients in the author's veterans practice prompted the search for a less uncomfortable approach. Methods that minimized discomfort or enhance cecal intubation included use of pediatric, variable stiffness, computer-assisted, 3-dimensional magnetic imaging colonoscope, gastroscope, and inhalation of nitrous oxide or insufflation of carbon dioxide; use of hypnosis, music, audio distraction, or simply allowing patients to participate in medication administration. In addition, several water-related techniques (as adjuncts to air insufflation) enhanced speed and success of intubation, reduced discomfort but did not appear to alter the amount of medications used. Because of simplicity, the water-related techniques added to turning off of the air pump were evaluated in a series of trial-and-error modifications. The result was the development of a water infusion in lieu of air insufflation method. Subsequent refinements included suction removal of all residual air to minimize angulations at flexures. Water exchange during insertion was used to suspend and removal feces to clear the luminal view while distention of the colonic lumen was minimize. Observational studies followed by randomized controlled trials confirmed the water method (simplified nomenclature) had significant impacts on discomfort both during and after colonoscopy: reduction of medication requirement; attenuation of insertion-related discomfort, enhancement of cecal intubation, decrease of pain after colonoscopy, increase in reported willingness to repeat unsedated colonoscopy in the patients examined without sedation and reduction of recovery time burden in patients accepting the option of sedation on demand.

Cap-assisted ERCP in Surgically Altered Anatomy / 대한소화기내시경학회지

BACKGROUND/AIMS: Endoscopic retrograde cholangiopancreatography (ERCP) is a difficult procedure to perform on patients who have undergone a Billroth II gastrectomy, Whipple's operation or Roux-en-Y gastrobypass surgery. Our study was designed to evaluate the clinical usefulness of cap-assisted ERCP for beginner endoscopists in cases of surgically altered anatomy. METHODS: From April 2008 to March 2010, 16 patients with biliary diseases and who had previously undergone abdominal surgery such as Billroth II gastrectomy or Roux-en-Y operation were analyzed. A single endoscopist performed all the procedures using a cap-assisted gastroscope, after ERCP training. RESULTS: Cap-assisted ERCP was attempted in 24 sessions of 16 patients. Afferent loop intubation and selective bile duct cannulation was successfully achieved in 19 sessions (79.1%). Among the patients who had undergone a Billroth II gastrectomy, 19 out of 20 sessions were successfully conducted. Only 4 patients who had undergone a previous Roux-en-Y operation failed afferent loop intubation. Duodenal free wall perforation developed in one case. There were no cases of mortality. CONCLUSIONS: Therapeutic cap-assisted ERCP was useful in patients who had previously undergone a Billroth II gastrectomy and this may be helpful for inexperienced endoscopists.

Virtual gastroscopy: a preliminary study on the use of trans-abdominal, fast three dimensional, colour coded ultrasound in the evaluation of gastric mass lesions

To assess the feasibility of trans-abdominal, fast three-dimensional, colour-coded ultrasound [3D CDUS] in the evaluation of gastric mass lesions compared to video endoscopy [VE] as the reference standard method. The study was conducted according to the guidelines of the local ethics committee. Informed consent was obtained from each patient. Sixty-three patients [34 males, 29 females; ages ranging from 21 to 72 years; mean 48.3 years] with VE-proven gastric mass lesions, from a population with gastric disorders, were included in this study. VE parameters and histopathology results remained blinded to the investigator. Fast 3D CDUS was performed on all patients and results interpreted. Finally, we reviewed the imaging results for each patient and compared them with previously obtained video recordings from VE and confirmed by histopathology. Compared to VE results, 61 out of 63 mass lesions were effectively diagnosed using 3D CDUS. In the remaining two cases [3.2%], a study of the gastric wall produced no conclusive findings. Our results showed an accuracy of 100% in benign gastric mass lesions, 95% in the evaluation of malignant involvement and an overall accuracy of 96.8%. Malignant stenotic segments and staging of malignant masses, which is mandatory if surgical intervention is planned, can be demonstrated by employing 3D CDUS. Fast 3D CDUS imaging is an easy, office-based, non-invasive method that has been shown to be effective for the evaluation of gastric mass lesions. Theoretically, it can also be used as a preliminary test in patient selection for endoscopy

Use of a standard gastroscope for colonoscopy and a general hospital in Venezuela: a prospective randomized trail

The use of an upper endoscope has been considered as a back-up method in case of incomplete caecal intubation. We compared caecal intubation rates between colonoscopic examinations done with a standard colonosope and those in which a standard gastroscope was used, to determine if routine colonosocpies could be performed with gastrocope if no colonoscope is available. A prospective comparative study, analyzing continuous date was designed to evaluate the usefulness of a standard gastroscope in a group of outpatients with indication for colonoscopy in colorectal cancer screening. At total of 170 adult patients were randomly assigned to two similar study groups. All examinations were performed by a single endoscopist. Our primary end point was to achieve caecal intubation. Successful caecal intubation was achieved in 162 patients that fulfilled our inclusion criteria. 83 patients in the colonoscope and 79 in the gastroscope group. Failure of caecal intubation was similar in male and female patients in both groups [p- 0.34]. Caecal intubation failure rates were similar in both study groups. We used the gastroscope as a first line method or routine colonosocpies and found no statistical difference between the colonoscope and gastroscope groups. If these results can be verified in larger mulicenter studies, it may be possible in the future, to work with only one endoscope for both upper and lower digestive tract examinations in small centers, particularly in developing countries

Application of ultrathin transnasal gastroscopy in percutaneous endoscopic gastrostomy / 南方医科大学学报

<p><b>OBJECTIVE</b>To assess the application of ultrathin transnasal gastroscopy in transnasal percutaneous endoscopic gastrostomy (nPEG) in patients with trimus and/or pharyngeal narrowing.</p><p><b>METHODS</b>Nine consecutive patients underwent PEG with the Introducer method using conventional gastroscopy (5 cases) or ultrathin transnasal gastroscopy (4 cases). Among the 4 patients undergoing nPEG, 3 received radiotherapy for nasopharyngeal cancer, including two with trimus and one with trimus and pharyngeal narrowing. The procedure time, safety, discomfort and complications in these cases were compared and evaluated.</p><p><b>RESULTS</b>The average procedure time of PEG was 17+/-3.5 min in conventional gastroscopy group and 17+/-3.1 min in nPEG group. No complications were observed in these patients, but the patients in nPEG group reported less discomfort associated with the procedure.</p><p><b>CONCLUSIONS</b>Ultrathin transnasal gastroscopy reduces the discomfort of the procedure and is safer than conventional gastroscopy for PEG, especially in patients with trimus and/or pharyngeal narrowing.</p>

An adult gastroscope instead of an adult colonoscope for colon examination in children / 中国当代儿科杂志

<p><b>OBJECTIVE</b>In some hospitals an adult colonoscope is used for colon examination in children because they do not have child colonscope equipment. This has some disadvantages and this paper reports the experience for colon examination in children with an adult gastroscope instead of an adult colonoscope.</p><p><b>METHODS</b>One hundred and three children aged from 1.3 to 14 years who required routine colon examination were randomly assigned to adult gastroscope (n=49) and adult colonoscope groups (n=54).</p><p><b>RESULTS</b>There were no significant differences in the success rate of implantation into the ileocecum between the gastroscope and colonoscope groups (93.9% vs 94.4%; P>0.05). The average time of implantation into the ileocecum in the gastroscope group was shorter than that of the colonoscope group (5.2+/-1.1 min vs 7.3+/-2.9 min; P<0.05). Seventeen patients showed implantation-related complications in the colonoscope group but only 5 patients in the gastroscope group (P<0.01).</p><p><b>CONCLUSIONS</b>An adult gastroscope appears to be safer and more feasible than an adult colonoscope for colon examination in children.</p>

Balloon dilation with gastroscope for esophageal stricture in children / 中华儿科杂志

<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of balloon dilation (BD) with gastroscope in treatment of esophageal stricture in children.</p><p><b>METHODS</b>BD was performed in 12 children aged 5 - 59 months, average age 26 months, course of disease was 2 - 26 months, with esophageal stricture, 7 cases with anastomotic strictures secondary to surgical repair of esophageal atresia, 3 with congenital esophageal stenosis, 2 with corrosive esophageal strictures. All procedures were performed under tracheal intubation and intravenous anesthesia using the 3rd grade controlled radial expansion (CRE) esophagus-balloon with gastroscope. Firstly the balloon was inserted into the esophagus through mouth, then put in the gastroscope. Under the direct guidance of gastroscope the balloon was positioned across the stricture, then the balloon was filled with saline to get needed pressure and maintained for 3 minutes. The procedure was repeated 3 times at an interval of 3 minutes. The abdominal pain, melena and vomiting were observed, as well as the diet taken thereafter, the size of the stricture and the nutrition status were observed for 3 to 12 months after the dilation.</p><p><b>RESULTS</b>Twenty-two dilations were performed in 12 cases, 19 succeeded, 3 cases developed complication during the dilation, the total success rate was 86%. The procedure failed in 3 cases and succeeded in 9 cases, the effective rate was 75%. Follow-up and repeated gastroscopy were performed within 3 to 12 months after the dilation, the diameter of the stricture was 9-13 mm, compared with 2-8 mm before the dilation. Eight of the children could take solid food and nutritional status was improved.</p><p><b>CONCLUSIONS</b>BD with the 3rd grade CRE esophagus-balloon under gastroscopy is a simple and effective method to treat esophagus stricture in children, especially for anastomotic strictures secondary to surgical repair of esophageal atresia.</p>

Transgastric Gastroscopic Intra-abdominal Exploration in a Female Dog Model: NOTES (Natural Orifice Transluminal Endoscopic Surgery)

PURPOSE: Natural orifice transluminal endoscopic surgery (NOTES) is a new surgical option using endoscopic advancement to the peritoneal cavity through the stomach, colon, vagina, or urinary bladder without an abdominal wall scar (incision). The aim of this study was to assess the feasibility of transgastric gastroscopic intra-abdominal exploration with gastric incision and closure before the NOTES would be done. METHODS: Under general anesthesia of a female dog, one-channel gastroscope was advanced to the stomach and the lumen was irrigated with anti-bacterial solution. The anterior wall of the antrum was incised by about 1 cm with a needle knife; then, the gastroscope was advanced into the peritoneal cavity. An exploration of the entire intra-abdominal cavity was performed. RESULTS: We were able to evaluate the stomach, the greater omentum, the diaphragm, the peritoneum, the urinary bladder, the bowel, the spleen, the liver, the gallbladder, the uterine horn, the uterine body, and the vagina, but could not evaluate the ovary, the kidney, and the pancreas. The observation of the abdominal cavity was followed by the gastric wall closure with a 135o endoclip. The dog was recovered after confirmation of secure closure of the incision site. CONCLUSIONS: Transgastric incision, closure, and abdominal exploration are feasible without an abdominal wall scar, and the NOTES can be one option for future abdominal operations in humans and needs to be further investigated.

Cáncer gástrico precoz: reporte de dos casos y revisión de la literatura: Servicio de Cirugía General del Hospital Universitario de Los Andes-Mérida / Early gastric cancer: report of a two cases and review of the literature: Service General of Surgery del Hospital Universitario de Los Andes-Mérida

Presentar dos casos clínicos de una patología frecuente, pero con diagnóstico precoz infrecuente. Revisión de la literatura y descripción de dos casos clínicos tratados en el Servicio de Cirugía General del Instituto Autónomo Hospital Universitario de Los Andes, Mérida-Venezuela, uno de ellos con el diagnóstico de cáncer gástrico precoz III antral, histológicamente adenocarcinoma bien diferenciado con compromiso de la submucosa, y otro con el diagnóstico de cáncer gástrico precoz lla + llc en cuerpo, histológicamente adenocarcinoma bien diferenciado que infiltra hasta la mitad superior de la submucosa sin linfoadenopatías, al que se le hizo ganglio centinela con azul patente infiltrado intramucoso, ambos fueron tratados quirúrgicamente con gastrectomía subtotal distal 75 por ciento D2 con una buena evolución post-operatoria y una sobrevida a los 5 años y 16 meses respectivamente. El carcinoma gástrico precoz de la clasificación de la Sociedad Japonesa de Gastroenterología se define como aquella neoplasia maligna confinada a la mucosa o submucosa del órgano, independientemente de la presencia de metástasis. Los programas de pesquisa para cáncer gástrico en zonas de alta incidencia, como Japón y China han permitido el diagnóstico de lesiones incipientes cercanas al 50 por ciento, pero en países subdesarrollados como el nuestro, estas lesiones se diagnóstican tan sólo en alrededor de 7-10 por ciento de los casos. El diasnóstico es basado en el examen histopatológico del fragmento resecado endoscópicamente o quirúrgicamente. Por considerarse como curable, es que su diagnóstico revise fundamental importancia en el pronóstico y sobrevida, la cual a los 5 años es mayor del 90 por ciento.

Descriptive Study on the Current Usage of Disinfectants in Korea / 병원감염관리

BACKGROUND: The proper use of disinfectants has been a major issue in infection control programs. We performed a survey to evaluate the current usage of disinfectants in Korea. METHODS: A questionnaire was e-mailed to 95 hospitals that had infection control programs and data were collected between 10 and 28 October 2005. The questionnaire included questions about whether the hospital had official procedures for selection and use of disinfectants and an education program for proper use; also included were questions about the general characteristics of the hospitals. The types of disinfectants consisted of antiseptics and disinfectants for medical devices, endoscopes, and environments. The questionnaire was analyzed using SPSS 12.0 program. RESULTS: Thirty-nine (41.1%) of the 95 hospitals responded to the questionnaire. Thirty-six hospitals (84.6%) had an official decision making process in selecting disinfectants in their hospitals. Ten percent povidone iodine (PVI) (94.9% for central line) and alcohol (92.3% for peripheral line) were commonly used for skin preparation for intravenous catheterization. Most hospitals used 10% PVI for clean wound (97.4%), dirty/infected wound (94.8%) and sore wound (61.5%); 3% H2O2 (43.6%) for dirty/infected wound; and saline (25.6%) for sore wound. Waterless alcohol handrubs were used in general ward (92.3%), ICU (97.4%), and OR (43.6%). Over the 60% of the hospitals used sodium hypochlorites for cleansing the floors and bathrooms of patients' rooms. As a disinfectant for endoscopes, peracetic acid (40-60%) was used the most frequently, followed by orth-pthalaldehyde (25-36%), and superoxidized water (8-23%). Most hospital followed the manufactures' guidelines on the exposure time of gastroscopes to disinfectants such as orth-pthalaldehyde (100%) and peracetic acid (96%). But, some hospitals re-used peracetic acid (12.0%) and superoxidized water (28.6%) for a longer duration than was recommended by the manufacturers. Fifty to eighty percents of the hospitals used tap water for rinsing endoscopes after disinfection, and only about 80% of these dried with alcohol after rinsing. Most hospitals (84.6%) had teaching sessions for the proper use of disinfectants more than once a year. CONCLUSION: The current use of disinfectants has been improved since 1999 in its suitability and appropriateness Proper use of disinfectants ensures the safety of invasive and non-invasive medical processes; therefore, the current guidelines for disinfection should be strictly followed by the hospital. And continuous staff education will facilitate the correct use of disinfectants.

Upper GI endoscopy in children- in an adult suite.

Although Upper GI endoscopy is commonly performed in adults, paediatric endoscopy is not available in many of our referral centres. The efficacy and safety of upper GI endoscopy in paediatric age group performed in adult suite of Kathmandu Medical College is reviewed. PATIENTS AND METHOD: A retrospective study of endoscopies performed on children aged up to 15 years in an adult endoscopy suite of Kathmandu medical college over last one year is presented. All cases were the referred cases from paediatric unit for various problems. RESULTS: Endoscopy in paediatric group comprises only 6% of total upper GI endoscopies performed during the same year. Sex ratio was almost equal. Most cases (87%) were performed under local anaesthetic and well tolerated by the patients. Recurrent abdominal pain (RAP) was the commonest indication and among them one third of cases had significant positive finding. CONCLUSION: Upper GI endoscopy is a useful diagnostic tool in children. Where specialized paediatric endoscopy units are not feasible i.e. developing countries, endoscopic services to children can be safely provided in adult endoscopy suite with or without sedation. Upper GI endoscopy is well tolerated by children even without sedation.

Análise microbiológica de gastroscópios descontaminados em aparelho Cleantop WM-1 por uso de água eletrolítica ácida / Microbiological evaluation of gastroscope decontamination by electrolysed acid water (Clentop WM-1)

RACIONAL: O método com utilização manual de glutaraldeído é amplamente empregado para desinfecção de endoscópios. A elevada rotina nos serviços de gastroscopia, pequena quantidade de equipamentos e a falta de conhecimento técnico sobre os processos de descontaminação contribuem para desinfecção inadequada dos endoscópios, intensificando o risco de transmissão de microrganismos. A água eletrolítica ácida tem apresentado eficácia na inativação e destruição de microrganismos e vem sendo usada na descontaminação de endoscópios. OBJETIVO: Verificar a eficiência microbicida da água eletrolítica ácida, produzida pelo aparelho Cleantop WM-1, em 20 gastroscópios contaminados após uso em pacientes. MATERIAL E MÉTODOS: Amostras coletadas do canal de biopsia dos endoscópios, após uso em pacientes (n = 20) e depois da desinfecção (n = 20), foram cultivadas em ágar tripticaseína de soja, MacConkey e Sabouraud dextrose. RESULTADOS: Dezessete das 20 amostras coletadas após o uso do aparelho em pacientes revelaram a presença de bacilos gram-negativos, cocos gram-positivos e leveduras em taxas de 103 a 105 ufc/mL. Nenhuma amostra, das 20 coletadas após a descontaminação, apresentou contaminação microbiana. CONCLUSÃO: Nesse estudo preliminar, a desinfecção mecânica realizada pelo aparelho Cleantop com água eletrolítica ácida revelou resultados satisfatórios pela eliminação de microrganismos e otimização no tempo de processamento dos gastroscópios.

Evaluación endoscópica de la mucosa gástrica del canino después de la administración oral de ácido acetil-salicílico en dosis terapéuticas durante 28 días / Canine gastric mucosal endoscopic evaluation after oral acetil-salicylic acid administration at therapeutic doses during 28 days

La mucosa gástrica de 18 caninos sanos fue examinada con un gastroscopio cada 7 días, durante la administración oral de ácido acetil-salicílico (aspirina) dos veces al día por un período de 28 días. Los caninos fueron divididos en 3 grupos, cada grupo constituido por seis. El grupo A como grupo control al cual no se le administró tratamiento. El grupo B al cual se le administró aspirina a dosis de 10mg/kg. El grupo C quienes recibieron una dosis de 20mg/kg. Los signos clínicos observados fueron anorexia y hematemesis, este último estuvo presente en un solo canino. Las lesiones gástricas fueron observadas sólo en los grupos B y C, las cuales aparecieron como lesiones petequiales, de petequiales a víbices, víbices, víbices a esquimóticas y úlcera. Utilizando el modelo estadístico de Kruskall-Wallis se observó que la presencia de lesiones en los grupos experimentales B y C con respecto al grupo control se debieron a la administración de aspirina. De acuerdo al modelo estadístico U de Mann-Whitney con respecto a la presencia de lesiones entre grupos B y C, no hubo diferencia significativa, es decir, ambas dosis ocasionaron efectos similares. Con respecto a la ubicación de la lesión las mismas fueron observadas en el cardias, cuerpo, fundus, antro, píloro e incisura angularis