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Braz. j. med. biol. res ; 25(10): 1025-7, 1992. tab, graf
Artículo en Inglés | LILACS | ID: lil-134646

RESUMEN

Resistance to MHV3 infection was investigated in genetically homogeneous inbred (A/J, BALB/c) and genetically selected (High, Low) mouse lines. The A/J and L lines are resistant and the BALB/c and H mice are susceptible. The genetic analysis was performed on the F1 hybrids, as well as on the genetically heterogeneous F2 populations and backcrosses bred from HxL and A/JxBALB/c lines. The mortality rates of the F1 hybrids showed codominance of susceptibility and resistance characters. The results indicate that the same MHV3 susceptibility genes are present in isogenic and selected lines and corroborate previous results showing that at least two major genes are involved in the control of this response


Asunto(s)
Animales , Masculino , Femenino , Infecciones por Coronavirus/inmunología , Hepatitis Viral Animal/inmunología , Virus de la Hepatitis Murina , Cruzamientos Genéticos , Infecciones por Coronavirus/genética , Infecciones por Coronavirus/mortalidad , Susceptibilidad a Enfermedades/genética , Hepatitis Viral Animal/genética , Hepatitis Viral Animal/mortalidad , Inmunidad Innata/genética , Ratones , Ratones Endogámicos A , Ratones Endogámicos BALB C
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