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Journal of Veterinary Science ; : 219-222, 2012.
Artículo en Inglés | WPRIM | ID: wpr-65173

RESUMEN

Reports of influenza A virus infections in dogs has received considerable attention from veterinarians, virologists, and epidemiologists. Interaction between influenza viral hemagglutinin and cell oligosaccharides containing sialic acid residues results in infection. Sialic acids have an alpha-2,3-linkage to the penultimate galactose in the avian influenza virus receptor and an alpha-2,6-linkage in the human receptor. To date, there are no detailed data on the tissue distribution or histological features of either type of sialic acid-linked influenza virus receptors in beagle dogs, which are common laboratory animals and pets. We conducted the current study to visualize the in situ tissue distribution of both sialic acid-linked influenza virus receptors in various organs of beagle dogs using Maackia amurensis lectin II and Sambucus nigra agglutinin. Both alpha-2,3- and alpha-2,6-sialic acid-linked receptors were detected in the endothelial cells of the respiratory tract and other organs. Endothelial cells of most gastrointestinal organs were negative for alpha-2,3-sialic acid-linked receptors in the dogs. Our results suggested that these canine organs may be affected by influenza virus infection. The findings from our study will also help evaluate the occurrence and development of influenza virus infections in dogs.


Asunto(s)
Animales , Femenino , Masculino , Enfermedades de los Perros/metabolismo , Perros/metabolismo , Subtipo H5N1 del Virus de la Influenza A/metabolismo , Maackia/química , Ácido N-Acetilneuramínico/metabolismo , Especificidad de Órganos , Infecciones por Orthomyxoviridae/metabolismo , Lectinas de Plantas/metabolismo , Receptores de Superficie Celular/análisis , Receptores Virales/análisis , Sambucus nigra/química
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