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Alexandria Journal of Pharmaceutical Sciences. 1992; 6 (2): 117-120
en Inglés | IMEMR | ID: emr-22841

RESUMEN

Differential scanning calorimetry [DSC] was mainly employed to predict the physicochemical incompatibility of 3 benzodiazepines, viz. temazepam, medazepam and lorazepam, with some common pharmaceutical excipients. The 3 drugs were found to be compatible with Avicel, Ac- Di-Sol, lactose, HPMC, dibasic calcium phosphate, starch, PVP and magnesium stearate. However, interactions of the benzodiazepines with PEG and stearic acid were detected and well confirmed utilizing TLC technique in addition to DSC


Asunto(s)
Farmacocinética , Temazepam/farmacocinética , Medazepam/farmacocinética , Lorazepam/farmacocinética
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