Consenso Colombiano de Tratamiento del Espectro de Acretismo Placentario (EAP) / Colombian Consensus on the Treatment of Placenta Accreta Spectrum (PAS)

RESUMEN Introducción: el espectro de acretismo placentario (EAP) es una condición asociada a sangrado masivo posparto y mortalidad materna. Las guías de manejo publicadas en países de altos ingresos recomiendan la participación de grupos interdisciplinarios en hospitales con recursos suficientes para realizar procedimientos complejos. Sin embargo, algunas de las recomendaciones de estas guías resultan difíciles de aplicar en países de bajos y medianos ingresos. Objetivos: este consenso busca formular recomendaciones generales para el tratamiento del EAP en Colombia. Materiales y métodos: en el consenso participaron 23 panelistas, quienes respondieron 31 preguntas sobre el tratamiento de EAP. Los panelistas fueron seleccionados con base en la participación en dos encuestas realizadas para determinar la capacidad resolutiva de hospitales en el país y la región. Se utilizó la metodología Delphi modificada, incorporando dos rondas sucesivas de discusión. Para emitir las recomendaciones el grupo tomó en cuenta la opinión de los participantes, que lograron un consenso mayor al 80 %, así como las barreras y los facilitadores para su implementación. Resultados: el consenso formuló cinco recomendaciones integrando las respuestas de los panelistas. Recomendación 1. Las instituciones de atención primaria deben realizar búsqueda activa de EAP en pacientes con factores de riesgo: placenta previa e historia de miomectomía o cesárea en embarazo previo. En caso de haber signos sugestivos de EAP por ecografía, las pacientes deben ser remitidas de manera inmediata, sin tener una edad gestacional mínima, a hospitales reconocidos como centros de referencia. Las modalidades virtuales de comunicación y atención en salud pueden facilitar la interacción entre las instituciones de atención primaria y los centros de referencia para EAP. Se debe evaluar el beneficio y riesgo de las modalidades de telemedicina. Recomendación 2. Es necesario que se definan hospitales de referencia para EAP en cada región de Colombia, asegurando el cubrimiento de la totalidad del territorio nacional. Es aconsejable concentrar el flujo de pacientes afectadas por esta condición en unos pocos hospitales, donde haya equipos de cirujanos con entrenamiento específico en EAP, disponibilidad de recursos especializados y un esfuerzo institucional por mejorar la calidad de atención, en busca de tener mejores resultados en la salud de las gestantes con esta condición. Para lograr ese objetivo los participantes recomiendan que los entes reguladores de la prestación de servicios de salud a nivel nacional, regional o local vigilen el proceso de remisión de estas pacientes, facilitando rutas administrativas en caso de que no exista contrato previo entre el asegurador y el hospital o la clínica seleccionada (IPS). Recomendación 3. En los centros de referencia para pacientes con EAP se invita a la creación de equipos que incorporen un grupo fijo de especialistas (obstetras, urólogos, cirujanos generales, radiólogos intervencionistas) encargados de atender todos los casos de EAP. Es recomendable que esos grupos interdisciplinarios utilicen el modelo de "paquete de intervención" como guía para la preparación de los centros de referencia para EAP. Este modelo consta de las siguientes actividades: preparación de los servicios, prevención e identificación de la enfermedad, respuesta ante la presentación de la enfermedad, aprendizaje luego de cada evento. La telemedicina facilita el tratamiento de EAP y debe ser tenida en cuenta por los grupos interdisciplinarios que atienden esta enfermedad. Recomendación 4. Los residentes de Obstetricia deben recibir instrucción en maniobras útiles para la prevención y el tratamiento del sangrado intraoperatorio masivo por placenta previa y EAP, tales como: la compresión manual de la aorta, el torniquete uterino, el empaquetamiento pélvico, el bypass retrovesical y la maniobra de Ward. Los conceptos básicos de diagnóstico y tratamiento de EAP deben incluirse en los programas de especialización en Ginecología y Obstetricia en Colombia. En los centros de referencia del EAP se deben ofrecer programas de entrenamiento a los profesionales interesados en mejorar sus competencias en EAP de manera presencial y virtual. Además, deben ofrecer soporte asistencial remoto (telemedicina) permanente a los demás hospitales en su región, en relación con pacientes con esa enfermedad. Recomendación 5. La finalización de la gestación en pacientes con sospecha de EAP y placenta previa, por imágenes diagnósticas, sin evidencia de sangrado vaginal activo, debe llevarse a cabo entre las semanas 34 y 36 6/7. El tratamiento quirúrgico debe incluir intervenciones secuenciales que pueden variar según las características de la lesión, la situación clínica de la paciente y los recursos disponibles. Las opciones quirúrgicas (histerectomía total y subtotal, manejo quirúrgico conservador en un paso y manejo expectante) deben incluirse en un protocolo conocido por todo el equipo interdisciplinario. En escenarios sin diagnóstico anteparto, es decir, ante un hallazgo intraoperatorio de EAP (evidencia de abultamiento violáceo o neovascularización de la cara anterior del útero), y con participación de personal no entrenado, se plantean tres situaciones: Primera opción: en ausencia de indicación de nacimiento inmediato o sangrado vaginal, se recomienda diferir la cesárea (cerrar la laparotomía antes de incidir el útero) hasta asegurar la disponibilidad de los recursos recomendados para llevar a cabo una cirugía segura. Segunda opción: ante indicación de nacimiento inmediato (por ejemplo, estado fetal no tranquilizador), pero sin sangrado vaginal o indicación de manejo inmediato de EAP, se sugiere realizar manejo en dos tiempos: se realiza la cesárea evitando incidir la placenta, seguida de histerorrafia y cierre de abdomen, hasta asegurar la disponibilidad de los recursos recomendados para llevar a cabo una cirugía segura. Tercera opción: en presencia de sangrado vaginal que hace imposible diferir el manejo definitivo de EAP, es necesario extraer el feto por el fondo del útero, realizar la histerorrafia y reevaluar. En ocasiones, el nacimiento del feto disminuye el flujo placentario y el sangrado vaginal se reduce o desaparece, lo que hace posible diferir el manejo definitivo de EAP. Si el sangrado significativo persiste, es necesario continuar con la histerectomía haciendo uso de los recursos disponibles: compresión manual de la aorta, llamado inmediato a los cirujanos con mejor entrenamiento disponible, soporte de grupos expertos de otros hospitales a través de telemedicina. Si una paciente con factores de riesgo para EAP (por ejemplo, miomectomía o cesárea previa) presenta retención de placenta posterior al parto vaginal, es recomendable confirmar la posibilidad de dicho diagnóstico (por ejemplo, realizando una ecografía) antes de intentar la extracción manual de la placenta. Conclusiones: esperamos que este primer consenso colombiano de EAP sirva como base para discusiones adicionales y trabajos colaborativos que mejoren los resultados clínicos de las mujeres afectadas por esta enfermedad. Evaluar la aplicabilidad y efectividad de las recomendaciones emitidas requerirá investigaciones adicionales.

ABSTRACT Introduction: Placenta accreta spectrum (PAS) is a condition associated with massive postpartum bleeding and maternal mortality. Management guidelines published in high income countries recommend the participation of interdisciplinary teams in hospitals with sufficient resources for performing complex procedures. However, some of the recommendations contained in those guidelines are difficult to implement in low and medium income countries. Objectives: The aim of this consensus is to draft general recommendations for the treatment of PAS in Colombia Materials and Methods: Twenty-three panelists took part in the consensus with their answers to 31 questions related to the treatment of PAS. The panelists were selected based on participation in two surveys designed to determine the resolution capabilities of national and regional hospitals. The modified Delphi methodology was used, introducing two successive discussion rounds. The opinions of the participants, with a consensus of more than 80 %, as well as implementation barriers and facilitators, were taken into consideration in order to issue the recommendations. Results: The consensus drafted five recommendations, integrating the answers of the panelists. Recommendation 1. Primary care institutions must undertake active search of PAS in patients with risk factors: placenta praevia and history of myomectomy or previous cesarean section. In case of ultrasound signs suggesting PAS, patients must be immediately referred, without a minimum gestational age, to hospitals recognized as referral centers. Online communication and care modalities may facilitate the interaction between primary care institutions and referral centers for PAS. The risks and benefits of telemedicine modalities must be weighed. Recommendation 2. Referral hospitals for PAS need to be defined in each region of Colombia, ensuring coverage throughout the national territory. It is advisable to concentrate the flow of patients affected by this condition in a few hospitals with surgical teams specifically trained in PAS, availability of specialized resources, and institutional efforts at improving quality of care with the aim of achieving better health outcomes in pregnant women with this condition. To achieve this goal, participants recommend that healthcare regulatory agencies at a national and regional level should oversee the process of referral for these patients, expediting administrative pathways in those cases in which there is no prior agreement between the insurer and the selected hospital or clinic. Recommendation 3. Referral centers for patients with PAS are urged to build teams consisting of a fixed group of specialists (obstetricians, urologists, general surgeons, interventional radiologists) entrusted with the care of all PAS cases. It is advisable for these interdisciplinary teams to use the "intervention bundle" model as a guidance for building PAS referral centers. This model comprises the following activities: service preparedness, disease prevention and identification, response to the occurrence of the disease, and debriefing after every event. Telemedicine facilitates PAS treatment and should be taken into consideration by interdisciplinary teams caring for this disease. Recommendation 4. Obstetrics residents must be instructed in the performance of maneuvers that are useful for the prevention and treatment of massive intraoperative bleeding due to placenta praevia and PAS, including manual aortic compression, uterine tourniquet, pelvic packing, retrovesical bypass, and Ward maneuver. Specialization Obstetrics and Gynecology programs in Colombia must include the basic concepts of the diagnosis and treatment of PAS. Referral centers for PAS must offer online and in-person training programs for professionals interested in improving their competencies in PAS. Moreover, they must offer permanent remote support (telemedicine) to other hospitals in their region for patients with this condition. Recommendation 5. Patients suspected of having PAS and placenta praevia based on imaging, with no evidence of active vaginal bleeding, must be delivered between weeks 34 and 36 6/7. Surgical treatment must include sequential interventions that may vary depending on the characteristics of the lesion, the clinical condition of the patient and the availability of resources. The surgical options (total and subtotal hysterectomy, one-stage conservative surgical management and watchful waiting) must be included in a protocol known by the entire interdisciplinary team. In situations in which an antepartum diagnosis is lacking, that is to say, in the face of intraoperative finding of PAS (evidence of purple bulging or neovascularization of the anterior aspect of the uterus), and the participation of untrained personnel, three options are considered: Option 1: In the absence of indication of immediate delivery or of vaginal delivery, the recommendation is to postpone the cesarean section (close the laparotomy before incising the uterus) until the recommended resources for safe surgery are secured. Option 2: If there is an indication for immediate delivery (e.g., non-reassuring fetal status) but there is absence of vaginal bleeding or indication for immediate PAS management, a two-stage management is suggested: cesarean section avoiding placental incision, followed by uterine repair and abdominal closure, until the availability of the recommended resources for safe surgery is ascertained. Option 3: In the event of vaginal bleeding that prevents definitive PAS management, the fetus must be delivered through the uterine fundus, followed by uterine repair and reassessment of the situation. Sometimes, fetal delivery diminishes placental flow and vaginal bleeding is reduced or disappears, enabling the possibility to postpone definitive management of PAS. In case of persistent significant bleeding, hysterectomy should be performed, using all available resources: manual aortic compression, immediate call to the surgeons with the best available training, telemedicine support from expert teams in other hospitals. If a patient with risk factors for PAS (e.g., myomectomy or previous cesarean section) has a retained placenta after vaginal delivery, it is advisable to confirm the possibility of such diagnosis (by means of ultrasound, for example) before proceeding to manual extraction of the placenta. Conclusions: It is our hope that this first Colombian consensus on PAS will serve as a basis for additional discussions and collaborations that can result in improved clinical outcomes for women affected by this condition. Additional research will be required in order to evaluate the applicability and effectiveness of these recommendations.

Difficulties in the Management of Placenta Accreta Spectrum in Hospitals with Limited Resources / Dificuldades na gestão do espectro da placenta acreta em hospitais com recursos limitados

Abstract Objective Placenta accreta spectrum (PAS) is a serious diseases, and the recommendation is that the treatment is conducted in centers of excellence. Such hospitals are not easy to find in low- and middle-income countries. We seek to describe the process of prenatal diagnosis, surgical management, and postnatal histological analysis in a low-income country referral hospital with limited resources. Methods A descriptive, retrospective study was carried out including patients with a pre- or intraoperative diagnosis of PAS. The clinical results of the patients were studied as well as the results of the prenatal ultrasound and the correlation with the postnatal pathological diagnosis. Results In total, 129 patients were included. Forty-eight of them had a prenatal PAS ultrasound diagnosis (37.2%). In the remaining 81 (62.8%), the diagnosis was intraoperative. Although hysterectomy was performed in all cases, one-third of the patients (31%) did not have a histological study of the uterus. In 40% of the patients who had a histological study, PAS was not reported by the pathologist. Conclusion The frequency of prenatal diagnosis and the availability of postnatal histological studies were very low in the studied population. Surgical skill, favored by a high flow of patients, is an important factor to avoid complications in settings with limited resources.

Resumo Objetivo O espectro da placenta accreta é uma patologia grave, cujo tratamento é recomendado emcentros de excelência. Esses hospitais não são fáceis de encontrar em países de baixa e média renda. Procuramos descrever o processo de diagnóstico prénatal, tratamento cirúrgico, e análise histológica pós-natal em um hospital de referência de baixa renda com recursos limitados. Métodos Foi realizado um estudo descritivo, retrospectivo, incluindo pacientes com diagnóstico pré ou intraoperatório de espectro da placenta accreta. Foram estudados os resultados clínicos das pacientes, bem como os resultados da ultrassonografia prénatal e a correlação com o diagnóstico patológico pós-natal. Resultados No total, 129 pacientes foram incluídas. Quarenta e oito delas tiveramum diagnóstico de ultrassom do espectro da placenta accreta pré-natal (37,2%). Nos 81 (62,8%) restantes, o diagnóstico foi intraoperatório. Embora a histerectomia tenha sido realizada em todos os casos, um terço deles (31%) não tinha estudo histológico do útero. Em 40% dos pacientes que tiveram estudo histológico, o espectro da placenta accreta não foi relatado pelo patologista. Conclusão A frequência do diagnóstico pré-natal e a disponibilidade de estudos histológicos pós-natais foram muito baixas na população estudada. A habilidade cirúrgica, favorecida por um alto fluxo de pacientes, é um fator importante para evitar complicações em ambientes com recursos limitados.

Acretismo placentario con compromiso vesical en altura / Placental accreta with bladder involvement in height

Introducción: El acretismo placentario es una complicación obstétrica compleja. Según el grado de profundidad se clasifica en placenta acreta, increta y percreta, siendo esta última una presentación rara. Objetivo: Reportar la evolución clínica quirúrgica de una paciente con diagnóstico de acretismo placentario (placenta percreta) con compromiso vesical. Caso clínico: Paciente segundigesta de 28 años, con antecedente de una cesárea anterior hace aproximadamente 4 años, ingresa por consultorio externo debido a estudio ecográfico sugestivo de probable acretismo placentario con invasión vesical realizada en el tercer trimestre, motivo por el cual es hospitalizada para un mejor estudio y tratamiento. Sometida a cirugía por equipo multidisciplinario, a cesárea-histerectomía modificada, con resección parcial de vejiga y ligadura de hipogástricas, con corta estancia en Unidad de Cuidados Intensivos y hospitalización sin complicaciones urológicas posteriores. Conclusiones: La detección temprana permite una planificación preoperatoria adecuada con equipo multidisciplinario especializado, considerando la participación temprana del urólogo en la toma de decisiones(AU)

Introduction: Placental accreta is a complex obstetric complication. According to the degree of depth, it is classified into placenta accreta, increta and percreta, the latter being a rare presentation. Objective: To report the surgical clinical evolution of a patient with a diagnosis of placental accreta (placenta percreta) with bladder involvement. Clinical case report: A 28-year-old second-pregnant patient, with a history of a previous cesarean section approximately 4 years ago, was admitted to an outpatient clinic due to a probable placental accreta with bladder invasion performed in the third trimester which was suggestive in ultrasound study. She was hospitalized for better study and treatment and she underwent surgery by a multidisciplinary team. A modified cesarean section-hysterectomy, with partial bladder resection and hypogastric ligation, with a short stay in the Intensive Care Unit and hospitalization without subsequent urological complications. Conclusions: Early detection allows adequate preoperative planning with a specialized multidisciplinary team, considering the early participation of the urologist in decision-making(AU)

Hemoperitoneo masivo como presentación de un caso de percretismo placentario / Massive hemoperitoneum as a rare presentation of placental percretism

El acretismo placentario se define como la invasión anómala de la placenta al miometrio, denominado percretismo en su forma más severa. En la actualidad se describe la coexistencia de placenta previa con cicatriz de cesárea, como el principal factor de riesgo. Siendo esta última variable la que explica su incidencia al alza en los últimos años. El pronóstico depende mayoritariamente del grado de adherencia, del diagnóstico prenatal y del adecuado manejo multidisciplinario. Con el objetivo de mostrar una presentación poco frecuente de percretismno placentario se presenta a continuación un caso clínico sin diagnóstico prenatal con requerimiento de cirugía de urgencia y su respectivo outcome.

Placental acretism is defined as an abnormal invasion of the placenta to the myometrium, it's most severe presentation being placenta percreta. The main risk factor for this disease is the coexistence of placenta previa and previous cesarean section. Its incidence has been progressively rising, mainly because of the increase in cesarean sections. Extent of adherence, prenatal vs intra surgery diagnosis, and multidisciplinary management are accountable for the prognosis of placental acretism. A case report with no prenatal diagnosis, which required emergency surgery, and its outcome is presented.

Evaluation of protocol of management of morbidly adherent placenta in maternity Zagazig university hospital

Background: Morbidly adherent placenta (MAP) defines the abnormal adherence of the placenta to the underlying uterine wall. It has a rising incidence world-wide. The risk of placental abnormalities increases in the presence of uterine scars due to cesarean delivery or gynecologic procedures. It may lead to massive obstetric hemorrhage resulting in serious complications such as DIC, transfusion related complications. Aim: Evaluation of protocol of management of patients with morbidly adherent placenta at Maternity Zagazig University Hospital and its effect on pregnancy outcome to find the best method of management to decrease associated morbidity and mortality.Patients and methods: This cohort study conducted on 120 patients diagnosed as having morbidly adherent placenta and were admitted to Zagazig University Hospitals.Results: In our study there were 48 cases (40%) managed by CS only and 72 cases (60%) managed by hysterectomy.Conclusion: well-planned caesarean hysterectomy with placenta left in situ adopting multidisciplinary approach is the recommended management option for MAP

Acretismo placentario: un diagnóstico emergente. Abordaje quirúrgico no conservador / Placental accreta: an emerging diagnosis. Approach non-conservative surgical

RESUMEN El espectro de acretismo placentario es un fenómeno infrecuente del embarazo cuya incidencia ha aumentado considerablemente y que está caracterizado por el anclaje anormal de las vellosidades coriónicas al miometrio, lo cual aumenta la morbi-mortalidad materna durante la resolución quirúrgica. Según las capas uterinas comprometidas, serán clasificadas como placenta acreta (contacta miometrio), increta (penetra miometrio) y percreta (compromete todo el miometrio y/o eventualmente órganos adyacentes), siendo su mayor factor de riesgo: la cesárea anterior y la placenta previa. En este artículo se realizó una revisión bibliográfica abarcando definiciones, diagnóstico y las nuevas tendencias en manejo quirúrgico no conservador propuesto en la nueva guía de la Federación Internacional de Ginecología y Obstetricia publicada en 2018 y elaborando una discusión respecto a ellas.

SUMMARY Placenta accreta spectrum is an uncommon phenomenon of pregnancy whose incidence has increased considerably over time and is characterized by the abnormal anchoring of the chorionic villi to the myometrium, which increases maternal morbidity and mortality during surgical resolution. According to the compromised uterine layers, they will be classified as placenta accreta (contacts myometrium), increta (penetrates myometrium) and percreta (compromises the entire myometrium and / or possibly adjacent organs), being previous caesarean section and placenta previous its major risk factor. In this review, we included definitions, diagnosis, and the new topics in non-conservative surgical management developed by the International Federation of Obstetrics and Gynecolgy published in 2018, and developing a discussion of the topic.

Rotura uterina durante el segundo trimestre de gestación asociado a placenta percreta: presentación de un caso y revisión de la literature / Uterine rupture during the second trimester of pregnancy associated with placenta percreta: presentation of a case and review of the literature

OBJETIVO: Reportar el manejo de un caso de rotura uterina asociado a percretismo placentario en el segundo trimestre de gestación; y realizar una revisión de la literatura acerca del diagnóstico y tratamiento de esta condición. PRESENTACIÓN DEL CASO: Paciente de 31 años con diagnóstico intraoperatorio de rotura uterina asociada a percretismo placentario a la semana 21 de gestación. Requirió manejo quirúrgico inmediato por abdomen agudo, presentando shock hipovolémico y muerte fetal in útero. Materiales y métodos: Se realizó una búsqueda de la literatura registrada en las bases de datos entre el año 1995 y 2017 y publicados en inglés y español. Se incluyeron los reportes de y series de caso y artículos de revisión, con relación al diagnóstico prenatal y tratamiento. RESULTADOS: La mayoría de los casos reportados de rotura uterina se describen en mujeres con rotura uterina por percretismo entre la semana 9 y 34 de gestación. El tratamiento es quirúrgico en la gran mayoría de casos y su abordaje dependerá de los hallazgos intraoperatorios y condiciones médicas asociadas. CONCLUSIÓN: El acretismo placentario presentado en etapas tempranas de la gestación es rara, sin embargo, se debe sospechar según hallazgos clínicos y paraclínicos. El manejo debe estar dirigido de acuerdo al grado de invasión placentaria y situación hemodinámica, la mayoría de las veces es quirúrgico y realizado por un equipo interdisciplinario.

OBJECTIVE: To report the management of a case of uterine rupture associated with placental percreta in the second trimester of pregnancy, and to make a review of the literature about the diagnosis and treatment of this condition. PRESENTACION OF THE CASE: A 31-year-old patient with intraoperative diagnosis of uterine rupture associated with placental percretism at week 21 of gestation, who required immediate surgical intervention for acute abdomen, which developed in a hypovolemic shock and fetal death in utero. MATERIALS AND METHODS: A Research was done of the literature registered in the databases between 1995 and 2017, and published in English and Spanish. We included case reports and case series and review articles, in relation to prenatal diagnosis and treatment. RESULTS: The majority of reported cases of uterine rupture that are found in women with this condition are due to percretism between week 9 and 34 of gestation. The treatment is surgical in the great number of cases, which procedure will follow depending on the intraoperative findings and associated medical conditions. CONCLUSION: Placental accreta presented at early stages of gestation is rare, however it should be taken into account while considering the clinical and paraclinical findings. The treatment must be directed accordingly to the degree of placental invasion and hemodynamic situation, although most of the time will lead to surgery performed by an interdisciplinary team.

Manejo del acretismo placentario en Servicios de Obstetricia de hospitales de alta complejidad Aplicación de un Proyecto de atención integral multidisciplinario / PLACENTA ACCRETA: MANAGEMENT AT OBSTETRIC SERVICES IN HIGH COMPLEXITY HOSPITALS

Objetivo: El objetivo del estudio fue describir el manejo de los Trastornos Adherenciales de la Placenta en la Maternidad de alta complejidad recabando los datos tanto del servicio de Obstetricia del Hospital Nacional Profesor Alejandro Posadas y Hospital Naval Pedro Mallo Buenos Aires. Diseño: Estudio de tipo observacional, descriptivo y transversal. Análisis estadístico mediante Stata 12.0. Resultados: Durante el período comprendido entre enero de 2010 y diciembre de 2014 fueron atendidas 30 pacientes con trastornos adherenciales placentarios. La incidencia de acretismo placentario en ese periodo fue de 0.18 (30/16210 nacimientos). El 56.67% (17/30) de las cirugías fueron programadas con Hemodinamia. En el 96.67% (N=29) el resultado anátomo-patológico final fue Acretismo Placentario. Hubo un caso falso positivo. Cuatro casos presentaron complicaciones potencialmente graves "near miss". No se presentaron muertes maternas. Conclusiones: Los trastornos adherenciales placentarios se presentan como un nuevo desafío para los Servicios de Obstetricia por la aparición en forma "epidémica" de una enfermedad que era infrecuente. El manejo multidisciplinario es la clave para un correcto tratamiento. El Obstetra cumple el rol de coordinación del mismo, convocando a las diferentes especialidades. Será entonces, de capital importancia el aporte de todos para la correcta resolución de los casos.

The aim of the present report was to describe the management of the adherencial disorders of the placenta in a high complexity maternity. During the period between January 2010 and December 2014, 30 patients with placental adherencial disorders were assisted. The incidence of placenta accreta during that period, was 0.18 (30/16210 deliveries). The 96.67 % of surgeries were programmed with Hemodinamia. In the 96.67 % (N= 29) the final anatomo-pathological result was Placentary Accretism. There was a false positive case. Four cases presented complications potentially severe "near miss". None maternal deaths were observed in the survey. The placental adherencial disorders present as a new challenge for the Obstetric Services because of their apparition in an "epidemic" way of a disease that was unfrequent. The multidisciplinary management is the key for an adequate treatment. Obstetricians play a roll for coordination of the team, convoking the different specialities. There will be then, of great importance, the contribution of the totality for the proper resolution of the cases

Placenta percreta, experiencia en 20 años del Hospital Universitario La Paz, Madrid, España / Placenta percreta: 20 years of experience in a university hospital

La placenta percreta es una rara enfermedad placentaria, con una incidencia muy baja y un muy difícil diagnóstico prenatal. Se presentan tres casos clínicos de placenta percreta recogidos en nuestro centro en los últimos 20 años. Se realiza una exposición detallada de cada uno de ellos, atendiendo fundamentalmente a la secuencia de acontecimientos quirúrgicos que tienen lugar tras el diagnóstico de esta grave entidad. La dificultad en el diagnóstico prenatal, así como la imperiosidad de las medidas terapéuticas, convierten a la placenta percreta en una enfermedad con una elevada morbilidad y mortalidad materna. El tratamiento quirúrgico así como la prevención y el tratamiento de la hemorragia posparto son las armas fundamentales para controlar esta gravísima complicación obstétrica.

The placenta percreta is a rare placental disease with a very low incidence and prenatal diagnosis difficult. We present three cases of placenta percreta observed in our hospital over the past 20 years. We present a detailed discussion of each of them, fundamentally to the sequence of surgical events that occur after the diagnosis of this serious entity. The difficulty of prenatal diagnosis, as well as the urgent therapeutic measures, make the placenta percreta in a disease with high morbidity and mortality. The surgical treatment and the prevention of postpartum hemorrhage are essential weapons to control this serious obstetric complication.

Placenta acreta / Placenta accreta

A implantação anormal da placenta na parede uterina configura a placenta acreta e é causa importante de morbimortalidade materna, devido ao grande risco de hemorragias.O diagnóstico pré-natal, sobretudo com ultrassonografia, é ideal porque permiteplanejar individualmente a conduta. Na maioria das vezes, entretanto, é feito no periparto, dificultando sua abordagem adequada. O tratamento pode ser conservador com o uso do metrotexato ou embolização das artérias uterinas, sendo realizado, em geral, pela remoção cirúrgica da placenta ou histerectomia.

Placenta accreta is a severe complication involving an abnormally deep attachment of the, through the and into the, and it is a important cause of maternal morbimortality, due the great risk of. The prenatal diagnosis, mainly through US, is the ideal, because a individual conduct can be done. But it is rarely recognised before birth, what dificults the treatment of this complication. The treatment can be conservative with methotrexato use or uterine artery embolization but, commonly requires, with the placenta resection or hysterectomy.

Conceito, diagnóstico e tratamento de placenta prévia acreta com invasão de bexiga: revisão sistemática da literatura / Concept, diagnosis and treatment of placenta previa accreta with urinary bladder invasion: systematic revision of literature

A placenta prévia consiste na implantação placentária no segmento inferior, distando no máximo 7 cm do colo do útero. Ao aderir-se diretamente ao miométrio, denomina-se placenta acreta; ao estender-se mais profundamente, placenta increta, e ao invadir a serosa uterina ou órgãos adjacentes, percreta. A incidência de placenta prévia varia de 0,3 a 1,7%, e a incidência do acretismo varia de 1:540 a 1:93.000 partos. Essa com acretismo é relacionada à alta morbimortalidade materna e, maior necessidade de terapêutica transfusional; a complicações durante a cesárea e à infecção. O acretismo é diagnosticado por ultrassom, ressonância magnética e, ultrassom com Doppler. A adequada detecção do acretismo permitirá o planejamento da via de parto e das medidas de segurança, com consequente redução da mortalidade materna. Feito o diagnóstico antenatal de acretismo placentário e invasão da bexiga, a conduta será a cesárea eletiva às 35 semanas com posterior histerectomia total abdominal, sempre com necessidade de uma equipe multidisciplinar (anestesistas, obstetras, cirurgião vascular intervencionista e urologista)

The placenta previa consists of a placental implantation in the inferior segment, distant at the most 7 cm of the cervix uteri. When adhering directly to the myometrium, it is called placenta accreta; when extending more deeply, increta and when invading the uterine's serous or even adjacent organs, the percreta. The placenta previa incidence varies from 0,3 to 1,7%, and the accretism from 1:540 to 1:93.000 childbirths. The placenta previa accreta is associated with high maternal morbidity and mortality, need of blood transfusion, complications during cesarean section and infection. The accretism is diagnosed by ultrasound, magnetic resonance and, ultrasound with Doppler. The appropriate detection of the accretism will allow the childbirth planning and safety's measures, with consequent reduction of maternal mortality. When the antenatal diagnosis of placenta accreta and invasion of the bladder are made, the conduct will be the elective cesarean section to the 35 weeks with subsequent abdominal total hysterectomy, with the aid of a team (anesthetists, obstetricians, surgeon vascular and urologist)

Acretismo placentario como urgencia en el servicio de obstetricia: presentación de casos / Placenta accreta as urgency in the obstetric service: presentation of a case

Se trata de la presentación de dos casos de acretismo placentario que ocurrieron en el Hospital Territorial Docente de Cárdenas, con menos de 48 horas de transcurridos de uno a otro, con confirmación de Anatomía Patológica y buena evolución de los pacientes y sus recién nacidos. En un caso se efectuó histerectomía subtotal post cesárea abdominal cuya indicación fue: embarazo a término, trabajo de parto, presentación pelviana, presunta placenta previa y cesárea anterior. En otro caso se efectuó histerectomía total post parto vaginal eutócico ante la imposibilidad de extracción manual de la placenta y hemorragia aguda.

We present two cases of placenta accreta attended at the Teaching Territorial Hospital of Cardenas, with less than 48 hours of difference, confirmed by Pathologic Anatomy and a good evolution of the patients and their newborns. In one case we made a subtotal hysterectomy after abdominal cesarean indicated as: term pregnancy, labor, pelvic presentation, presumed previous placenta and anterior cesarean. In the other, we made a total hysterectomy after eutocic vaginal delivery because of the impossibility of manually extracting placenta and acute hemorrhage.

Actualidad en el diagnóstico y manejo del acretismo placentario / Update on the diagnosis and treatment of placenta accreta

El acretismo placentario es una entidad que incrementa considerablemente la morbimortalidad materna y fetal. Gracias al advenimiento de nuevos métodos diagnósticos como la resonancia magnética, la cistoscopia, los marcadores séricos, el ultrasonido doppler, etc., el diagnóstico prenatal es factible. El manejo del acretismo placentario de forma tradicional supone la realización de histerectomía multidisciplinaria, involucrando a cirujanos generales, oncoginecólogos o uroginecólogos. Algunos autores han propuesto al manejo conservador como una solución adecuada en ciertos casos, ya sea con el uso de diversos medicamentos que incluyen quimioterápicos o bien de forma expectante. Sin embargo, aún no existe evidencia sólida que determine si el manejo conservador o tradicional es el mejor.

Placenta accreta supposes a special situation that increases the fetal and maternal mo rb i mortality of considerable form. Thanks all new arrival methods as the image of magnetic resonance, the cystoscopy, serum markers, doppler ultrasound, etc., the prenatal diagnostic is feasible. The management of placenta accreta of traditional form supposes a multidisciplinary approach form hysterectomy execution, involving general surgeons, oncogynecologist or urogynecologist. Some authors have proposed the conservative management as an adequate solution in certain cases, whether with the use of several drugs including chemotherapy or expectant form. Nevertheless, not yet solid evidence exists if the surgical traditional approach or the conservative management is the best option.

A Case of Placenta Increta Presenting as Delayed Postabortal Intraperitoneal Bleeding in the First Trimester

Placenta increta is an uncommon and life-threatening complication of pregnancy characterized by complete or partial absence of the decidua basalis. Placenta increta usually presents with vaginal bleeding during difficult placental removal in the third-trimester. Although placenta increta may complicate first and early secondtrimester pregnancy loss, the diagnosis can be very difficult during early pregnancy and thus the lesion is difficult to identify. We encountered with a woman who was diagnosed with placenta increta after receiving emergency hysterectomy due to intraperitoneal bleeding 2 months after an uncomplicated dilatation and curettage in the first trimester. Therefore, we report this case with a brief review of the literature.

Valor da ressonância magnética no diagnóstico antenatal do acretismo placentário / Value of magnetic resonance imaging in prenatal diagnosis of placental accretism

OBJETIVOS: estabelecer os principais sinais de acretismo placentário na ressonância magnética (RM) em gestantes com suspeita clínica e avaliar a utilidade do método. MÉTODOS: estudo prospectivo, transversal em 15 pacientes com suspeita de acretismo placentário. O período compreendido foi de março de 2003 a fevereiro de 2006. A idade gestacional variou de 20 a 31 semanas. Todas as pacientes realizaram RM com estudo dirigido para placenta e haviam sido submetidas à ultra-sonografia (US) prévia ao exame. Todas as peças foram encaminhadas para estudo anátomo-patológico (AP). Os exames foram realizados nos equipamentos Magnetom Impact e Sonata Maestro Class Siemens®, adquiridas as seqüências HASTE, TURBO FISP, nos planos axial, sagital e coronal e gradiente echo (GE®) pré- e pós- contraste dinâmico no melhor plano de aquisição. A análise das imagens foi realizada por dois radiologistas em consenso. RESULTADOS: a idade gestacional média das pacientes foi de 24,3 semanas. Foram estudadas sete placentas prévias centro-totais (47 por cento), seis placentas corporais anteriores (40 por cento) e duas placentas corporais posteriores (13 por cento). A US foi positiva em 80 por cento dos casos e a RM em 53 por cento dos casos. No entanto, a US apresentou concordância fraca com o AP pelo teste de kappa (11 por cento), com sensibilidade de 75 por cento, especificidade de 14 por cento, valor preditivo positivo (VPP) de 50 por cento e valor preditivo negativo (VPN) de 33 por cento. Já a RM teve concordância excelente com o AP (0,86), com sensibilidade de 100 por cento, especificidade de 86 por cento , VPP de 89 por cento e VPN de 100 por cento. CONCLUSÃO: a RM é útil na identificação do acretismo placentário. Os principais sinais na RM do acretismo placentário são: o hipersinal transmural, a descontinuidade da parede miometrial nas seqüências rápidas e a identificação dos vasos invadindo o miométrio nas seqüências dinâmicas.

PURPOSE: to establish the main signs of placental accretism in magnetic resonance imaging (MRI) in patients with clinical suspicion and to estimate the benefit of this method. METHODS: prospective transversal study with 15 patients suspected of placental accretism, referred between March 2003 and February 2006. Gestational age varied from 20 to 31 weeks. All patients underwent MRI to study the placenta and had previously done an ultrasonography. Material was sent to histological study. MRI was done on Magnetom Impact and Sonata Maestro Class Siemens®, with acquired sequences HASTE, TURBO SPIN in axial, sagittal, coronal planes and echo gradient (GE®), pre- and post-dynamic contrast in the best plan for acquisition. Images were analyzed by a team of two radiologists. RESULTS: mean gestational age was 24.3 weeks. We studied seven placenta previa (47 percent), six anterior placentas (40 percent) and two posterior placentas (13 percent). Ultrasonography was positive in 80 percent of the palcentas and MRI in 53 percent. However, echography had a low concordance with anatomic pathological studies by Kappa test (11 percent), revealing 75 percent of sensitivity, 14 percent of specificity, 50 percent as positive predictive value (PPV) and 33 percent as negative predictive value (NPV). MRI had an excellent concordance with anatomic pathological studies (0.86), showing 100 percent of sensitivity, 86 percent of specificity, 89 percent as PPV and 100 percent as NPV. CONCLUSIONS: MRI is useful for placental accretism diagnosis. The principal findings are transmural hyper-signal, the loss of continuity in myometrial wall in fast sequences and the identification of vessels invading myometrial layer in dynamic sequences.

A multidisciplinary approach to surgical management of placenta previa percreta with bladder invasion: a case report

Placenta previa percreta with bladder invasion occurs rarely. However this disorder has become more common since the increased rate of cesarean deliveries. We present a 26 year old gravida 3, para 2-0-1-2 female with placenta previa, percreta and bladder invasion to stress out the importance of early recognition of this life threatening condition and to point out that the good outcome of this case was mainly due to the multidisciplinary approach chosen during the preoperative and post operative management. The Departments of Obstetrics and Gynecology, Radiology, Anesthesiology, Urology, Neonatology and Pathology were fully involved. A surgical management was chosen since it is the most common and more accepted treatment of placenta previa percreta with bladder invasion.

Placenta percreta con invasión vesical: reporte de 2 casos / Placenta percreta with urinary bladder involvement: report of two cases

Se presentan dos casos clínicos de placenta percreta. Uno como hallazgo intraoperatorio y otro con diagnóstico antenatal. Se describen los procedimientos diagnósticos, el manejo quirúrgico intra y post operatorio y el seguimiento, así como el enfrentamiento y la reparación de las complicaciones encontradas. Se hace énfasis en la importancia del trabajo en equipo multidisciplinario en estos casos extremadamente graves. Se revisa la literatura y se sugieren algunas recomendaciones para su mejor manejo.