RESUMEN
Highly reactive zinc metal was prepared by electrolysis of a N,N-dimethylformamide (DMF) solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This highly reactive electrogenerated zinc (EGZn/Naph) was used for transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which can not be achieved by the use of usual zinc metals. Reaction of the organozinc compounds thus prepared with various aryl halides in the presence of 5 mol% of palladium catalyst gave the corresponding cross-coupling products in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursor of anti-inflammatory agents such as ibuprofen, naproxen, cicloprofen and suprofen.
Asunto(s)
Antiinflamatorios no Esteroideos/síntesis química , Catálisis , Electrólisis , Ibuprofeno/síntesis química , Naftalenos , Naproxeno/síntesis química , Profármacos/síntesis química , Propionatos/síntesis química , Suprofeno/síntesis química , Zinc/farmacologíaRESUMEN
Foram sintetizadas tres series de derivados do acido 3-fosfonopropionico, compreendendo 22 substancias, das quais 16 ainda nao descritas na literatura. Todas as substancias foram caracterizadas por analise elementar, espectroscopia no infravermelho e espetrometria de ressonacia magnetica protonica. Os compostos obtidos foram encaminhados para ensaios experimentais na doenca de Chagas