RESUMEN
OBJECTIVE@#To establish a screening and confirmation method for psychotropic drugs and their metabolites in human blood and urine by HPLC-LTQ Orbitrap MS.@*METHODS@#The samples were pretreated with Sirocco protein precipitation plate, and then analyzed by HPLC-LTQ Orbitrap MS. The method was validated in terms of the limit of detection (LOD). An accurate mass database was created for psychotropic drugs screening.@*RESULTS@#The LOD for most of 56 determined compounds was < or = 0.1 ng/mL. The accurate mass database included the accurate mass information of 61 psychotropic drugs.@*CONCLUSION@#The method is accurate, rapid, sensitive and the database is suitable for psychotropic drugs screening and confirmation.
Asunto(s)
Humanos , Cromatografía Líquida de Alta Presión/métodos , Toxicología Forense , Espectrometría de Masas/métodos , Estructura Molecular , Peso Molecular , Psicotrópicos/orina , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Detección de Abuso de Sustancias/métodosRESUMEN
Se realizó un estudio descriptivo desde Octubre a Diciembre de 2008 en la Emergencia del Hospital Vilardebó estableciéndose la prevalencia del consumo de sustancias psicoactivas en los pacientes que ingresaban por Trastornos Psicóticos. La presencia de consumo reciente se estableció por autorreporte y test en orina para marihuana y cocaína/ pasta base de cocaína. La prevalencia del consumo reciente en los pacientes con Trastornos Psicóticos fue de 17,9 por ciento. Los pacientes con testeado positivo mostraron una tasa total de ingresos mayor que aquella del grupo de los no consumidores, y los ingresos en el último año fueron claramente mayores para el grupo que consume cocaína y sus derivados.
A descriptive study was conducted from October to December 2008 in the emergency room of Hospital Vilardebó (State Mental Facility) to establish the prevalence of psychoactive substance use in patients admitted for Psychotic Disorders. The presence of recent use of substance was established by self-report and urine test for marijuana and cocaine / cocaine base. The prevalence of recent use in patients with psychotic disorders was 17.9 percent. Patients who tested positive showed a total hospitalization rate greater than that of the group of nonusers, and hospitalization in the last year were clearly higher for the group who uses cocaine and its derivatives.