A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin

A study was conducted in São Paulo, Brazil, to compare azithromycin with thiamphenicol for the single-dose treatment of chancroid. In all, 54 men with chancroid were tested. The etiology was determined by clinical characterization and direct bacterioscopy with Gram staining. None of the patients had positive serology or dark-field examination indicating active infection with Treponema pallidum. Genital infections due to Neisseria gonorrhoeae and herpes simplex virus were excluded by polymerase chain reaction testing. For 54 patients with chancroid, cure rates with single-dose treatment were 73 percent with azithromycin and 89 percent with thiamphenicol. HIV seropositivity was found to be associated with treatment failure (p=0.001). The treatment failed in all HIV positive patients treated with azithromycin (p=0.002) and this drug should be avoided in these co-infected patients. In the view of the authors, thiamphenicol is the most indicated single-dose regimen for chancroid treatment.

Thiamphenicol in the treatment of chancroid: a study of 1.128 cases

Thiamphenicol, an aminic derivate of hydrocarbilsulfonil propandiol, was used for the treatment of 1,171 chancroid bearing patients. Each patient was medicated with 5.0 g of granulated thiamphenicol, orally, in a single dose, and was reevaluated 3, 7 and 10 days after the treatment. Ten patients (0.89 percent) did not respond to the proposed treatment. 133 patients presented healed ulcers after 3 days of treatment, 976 patients healed chancres on the seventh day after the treatment, and 39 patients took 10 days to present healed chancres. The results of this study indicate that the rate of patients that were cured, the low incidence of side effects, and the practicality of administration make of thiamphenicol an excellent choice for the treatment of chancroid.

Avaliacao de uma nova classificacao do risco de contaminacao em procedimentos obstetricos / Evaluation of a new classification of contamination risk for obstetric procedures

Foram comparadas duas formas de administracao de antibioticos, orientadas por duas classificacoes distintas do risco de contaminacao em procedimentos obstetricos. O estudo inclui 3347 pacientes submetidas a procedimentos obstetricos durante o ano de 1990. Observou-se uma reducao significativa do indice de infeccao puerperal de 6,72 para 2,59 por cento com a introducao de uma classificacao mais rigorosa do risco de contaminacao e de antibioticoterapia profilatica. Os autores concluem que a utilizacao profilatica de antibioticos orientada por uma classificacao rigorosa do risco de contaminacao em procedimentos obstetricos foi eficiente na reducao do indice de infeccao puerperal.