Imidazoles containing biologically active units II- Synthesis of some 4-arylidene-2-aryl-5-oxo-4, 5dihydroimidazoles

4-arylidene-2-aryl-5-oxo-4, 5-dihydroimidazoles [II] were synthesized through interaction of the corresponding 4-arylidene-2-aryl-5-oxo-4, 5-dihydrp-l, 3-oxazoles [I] with ammonium acetate in acetic acid and in presence of fused sodium acetate. Alkylation of [II] gave l-alkyl-4-arylidene-2-aryl-5-oxo-4, 5-dihydro-imidazoles [III] which were found to be exactly identical with those obtained by direct interaction of [I] with amines. Several types of imidazoles were prepared. Interaction of [I] with hydrazines was also discussed. Some of the newly described compounds were tested for antimicrobial activity

Some visnagin derivatives and related compounds Part I

Visnagin-9-sulphonyl chloride [II] was prepared and reacted * with ammonium acetate to give the corresponding sulphonamide [IIIa] which was acetylated to IV. Interaction of II with hydrazine hydrate gave V which reacted with aldehydes and with sulphonyl chlorides to give VI and VII respectively. Oxidation of visnagin [I] with chromic acid gave VIII which reacted with hydrazine hydrate to give the hydrazone [IX]. Interaction of IX with aldehydes and with sulphonyl chlorides gave X and XI respectively. Cyclization of VIII with ethylacetoacetate furnished the alpha.-pyrono -gamma- chomone [XIII] which reacted with aldehydes to give XIV

Visnagin containing biologically active units Part I

Visnagin-8-Sulphonyl chloride [I] has been prepared? nd react with p-aminodiphenylamme to give [II] which converted to the phenothiazene [III] and acridine [IV] derivatives. Interaction of [I] with p-hydroxybenzaldehyde give the sulphonic ester [VIa] which react with hippuric acid to give the oxazolin-5-one [VIIa], the later on reaction with amines furnish the imidazolin-5-ones [VII b-d]. Also, [I] react with p-aminobenzoic acid to give [VIII] which react with alcohols, primary and secondary amines to give the corresponding esters, primary and secondary amides [IX and X] respectively. Aliphatic, aromatic, heterocyclic and secondary sulphonamides [XV - XVIII] of [I] have been prepared, then XV react with acetyl chloride to give XIX, while XVI react with aldehydes to give the styryl derivatives XX

Synthesis of some visnagin derivatives with expected biological activity

Visnagin [Ib] isolated from the Egyptian plant Ammi visnaga L-selective antispasmodic effect upon the ureter, bronchial, muscles and gall bladder. This led the authors to prepare a number of Visnagin derivatives and analogues in the hope of improving its activity. Thus Ib and its analogues [la, c and d] were reacted with P2S5 in xylene to give the thiones [IIa-d]. Their IR spectra showed the absence of v CO and the presence of v CS at 1150. In addition they gave positive H2O2/BaCl2 oxidation test and lib formed a complex [III] when treated with HgCl2 [a reaction which is characteristic of the thione group

Interaction of grignard reagents with benzalphthalides and benzalphthalimidines

3 benzalphthalide [ia] was reported [1,2] to react with methyl - and Phenylmagnesium halides to give the indonederivatives [IIa and b] respectively. The aim of the present investigation was to extent this reaction to other benzalphthalides, benzalphthalimidine-s and different Grignard reagents

Some new-xanthotoxin derivatives with expected biological activity

Xanthotoxin-4-Sulphonyl chloride [I] was reacted with some -sulpha derivatives to give II and with p-aminobenzoic acid to give IIIc which converted to the corresponding esters [IV], primary and secondary amides [V and VI]. p-Aminodiphenyl-amine was reacted with I to give Xa which converted to acridine and to phenothiazene derivatives [XI and XII]. The sulphonic acid ester [XIIIc] was prepared from I and p-hydroxybenzaldehyde which then reacted with hippuric acid to give the oxazolin-5-one derivative [XIV]. Another type of Xanthotoxin sulphonamides [XXI] were prepared from 4-aminoxanthotoxin and the corresponding sulphonyl chloride