Role of multidetector computed tomography prostatic perfusion in diagnosis of prostate cancer

To evaluate the role of multidetector computed tomography prostatic perfusion in diagnosis of prostate cancer. From November 2007 to December 2009, 112 patients with suspected prostate cancer [with no previous histologic proof of prostate cancer] performed multidetector computed tomography prostatic perfusion followed by TRUS examination results were correlated with histopathological results from TRUS guided biopsy of the prostate were included in this thesis study. Our results are yielding multidetector computed tomography [functional ct "fct"] evaluation for detection of malignancy with sensitivity 90.54%, specificity 86.8%, positive predictive value 93.056%, negative predictive value 82.5%, accuracy 89.3% and pre-test probability = 64.3%. Multidetector computed tomography prostatic perfusion is a sensitive imaging modality the diagnosis of prostate cancer and should be routinely employed for raising the positive predictive value of prostatic biopsy

Synthesis and reaction of pyrido[2,3-d] pyrimidine with related thiazolo and enaminonitrile derivatives

In a one-pot synthesis pyrido[2,3-d] pyrimidine-2-thione derivatives [3a-c] were prepared via the reaction of a mixture of 6-aminothiouracil [1], cyclooctanone and a proper aldehyde in dimethylformamide. Compound 3 reacted with a mixture of chloroacetic acid and aromatic aldehyde in acetic acid and acetic anhydride to give 6-aryl-thiazolo [4,5-a] cyclooctenopyrido [2,3-d] pyrimidine -3,5-diones [4a-c]. Compound 3b underwent cyclization on boiling with 3-chloro-2,4-pentandione in acetic anhydride/pyridine solution to give 5. On the other hand, compound 3b reacted with bromo-malononitrile to give enaminonitrile [6] Compound 6 reacted also with aliphatic acids to give 14-[chlorophenyl]-2-[unsub./methyl] pyrimido[4',5':4,5] thia-zolo[3,2-a] cyclooctenopyrido [23-d] pyrimidine- 4,15- dione [8a,b]

Synthesis of furo [3,2-e] [1,2,4] triazolo [1,5-c] -pyrimidines and furo [3,2-e] pyri-mido [4,3-f] [1,2,4] -triazin-3-one: a new ring system

2-amino-4,5-diphenylfuran-3-carbonitril [I] reacted with triethyl orthoacetate to give the 4,5-diphenyl-2-[alpha-ethoxyethylideneamino] furan-3-carbonitrile [II]. The latter compound was converted into the 5,6-diphenyl-3H, 4H-4-imino-2-methylfuro [2, 3-d] pyrimidine [III]. Reaction of [III] with alpha-cyanocinnamonitrile derivatives produced the 2-aryl-8,9-diphenyl-5-methylfuro [3,2-e] [1,2,4]-triazolo [1,5-c] pyrimidines [Va-c]. Compound III reacted with acetic anhydride to yield the 2,3-dimethyl-8,9-diphynlylfuro [3,2-e] [1,2,4] triazolo-[1,5-e] pyrimidine [VI] and with triethyl orthoformate to produce the 2-unsubstituted derivatives of VI [VII]. Reaction of III with carbon disulfide gave the 2,3-dihydro-8, 9-diphenyl-5-methylfuro-[3,2-e] [1,2,4] triazolo [1,5-c] pyrimidine-2-thione [VIII]. Compound III reacted with ethyl chloroacetate to yield the 2,3-dihydro-9, 10-diphenyl-4H-6-methylfuro [3,2-e] pyrimido [4,3-f] [1,2,4]-triazin-3-one [IX], with a new ring system

Synthesis and reactions of some derivatives of 2-amino-5- [4-pyridyl] -1,3,4-oxadizole

By the reaction of 2-amino-5- [4-pyridyl]-1, 3, 4-oxadiazole [1] with aldehydes, the corresponding arylideneimino derivatives [2a-f] were obtained which when reacted with arylisocyanates or benzoylisothiocyanates afforded the corresponding oxadiazolo [3, 2- a]-1, 3, 5- triazines [3 a-g]. The reaction of I with benzoyl- isothiocyanate was also investigated. 3-phenyl 1-6-[4-pyridyl] -1, 2, 4-triazolo [3, 4-b]-1, 3, 4-oxadiazole [6] was obtained on reacting products 4, 9, or 10 with hydrazine hydrate

Reactions with alpha-substituted cinnamonitriles: synthesis of benzo [h] quinolines and naphthol [1,2, b] pyrans

Alpha-substituted cinnamonitrile derivatives [1a-i] reacted with alpha-tetralone [2] in the presence of ammonium acetate to yield 5, 6-dihydrobenzo [h] quinoline derivatives with different substituents at 2,3, and 4 positions [3,7-9]. Substituting sodium acetate for ammonium acetate led to the formation of the 5, 6-dihydro-2-imino-4-phenylnaphtho [1, 2-b] pyran-3-carbonitrile [5]

Synthesis of some 3-cyano5,6-dihydropyridines-2-ones and their n-substituted derivatives

3-Cyano-5,6-dihydro-4,6-disubstituted-6-methylpyridin-2-ones [2a-d] were prepared by condensation of methyl ketones and ethyl cyanoacetate in a 2:1 molar ratio in presence of ammonium acetate. The obtained pyridones [2a] and 2b] add diethyl acetylenedicarboxylate, acrylonitrile and methyl acrylate to give the corresponding N-substituted derivatives 3, 4 and 5 respectively. Several reports have been published dealing with the reaction of ethyl cyanoacetate with c,[B-unsaturated ketones to give 3- cyano-4, 6-disubstituted pyridin-2- ones [1-7], some of which were found to possess a pronounced antimicrobial activity [6-7]. In the present work, some dihydropyridone derivatives and related compounds have been synthesized by the condensation of ethyl cyanoacetate with some methyl ketones