Résumé
The objective of this study was to evaluate the morphological alterations and time-kill of the essential oil of the leaves of C. sativum L. on strains of C. albicans. The essential oil was submitted to gas chromatography-mass spectrometry analysis. The predominant component identified was linalool (39.78 percent). Minimal inhibitory concentration and minimal fungicidal concentration of the essential oil were respectively 512 and 1024 ug.mL-1 for 90 percent of the strains tested. In the time-kill curves, the essential oil showed a concentration-dependent fungicidal effect. In the micromorphology assay it caused a significant reduction in pseudohyphae, an important pathogenic factor of C. albicans.
El objetivo de este estudio fue evaluar las alteraciones morfológicas y de letalidad del aceite esencial de las hojas de C. sativum L. en cepas de C. albicans. El aceite esencial se presentó a gas análisis de espectrometría de cromatografía-masa. El componente predominante identificado fue linalol (39,78 por ciento). Concentración inhibitoria mínima y concentración mínima fungicida del aceite esencial fueron, respectivamente, 512 y 1.024 ìg.mL-1 para 90 por ciento de las cepas probadas. En las curvas el tiempo-matar, el aceite esencial mostró un efecto fungicida dependiente de la concentración. En el ensayo de micromorfología causó una reducción significativa en pseudohifas, un importante factor patógeno de C. albicans.
Sujets)
Antifongiques/pharmacologie , Candida albicans , Coriandrum/composition chimique , Huile essentielle/pharmacologie , Feuilles de plante/composition chimique , Apiaceae/composition chimique , Chromatographie gazeuse-spectrométrie de masse , Tests de sensibilité microbienne , Monoterpènes , Facteurs tempsRésumé
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disorder characterized by late-infantile onset spastic ataxia and other neurological features. ARSACS has a high prevalence in northeastern Quebec, Canada. Several ARSACS cases have been reported outside Canada in recent decades. This is the first report of typical clinical and neuroimaging features in a Brazilian family with probable diagnosis of ARSACS.
A ataxia espástica autossômica recessiva de Charlevoix-Saguenay (ARSACS) é doença degenerativa do sistema nervoso, caracterizada por ataxia associada a espasticidade, entre outras manifestações neurológicas, de início na infância. A doença tem alta prevalência na região de Quebec, no Canadá. Muitos relatos de ARSACS têm sido descritos fora do Canadá nas últimas décadas. Nesse artigo, relatamos a primeira descrição dos aspectos clínicos e de neuroimagem típicos em uma família brasileira com provável diagnóstico de ARSACS.