Résumé
In this study, 223 bone marrow biopsies and / or aspirations were performed. The main indications for bone marrow examination were diagnosis and management of acute leukaemia [45-20.2%], staging of lymphoma [29-13.1%], evaluation of pancytopenia [31-14.1%], thrombocytopenia [26-11.7%], anaemia [16-7. 2%], pyrexia of unknown origin [PUO] [14-6.1%], lymphadenopathy [16-7. 3%], hepatosplenomegaly [12-5.3%], to exclude metastasis [7-3.2%] and miscellaneous [25-11%]. The most common diagnosis encountered were: acute lymphoblastic leukaemia [35-15.7 %], idiopathic thrombocytopenic purpura [13-5.7%], acute myeloid leukaemia [12-5.7%], hyper8plenism [12-5.7%], chronic myeloid leukaemia [12-5.7%], megaloblastic anaemia [7-3.1%] and multiple myeloma [3-1.3%]. It was concluded that bone marrow examination is an important investigation for establishing the diagnosis in many conditions especially haematological neoplasms. The most common indication in this study was to confirm and manage acute leukaemia and the most common diagnosis was acute lymphoplastic leukaemia
Résumé
Helicobacter pylori [H. pylori] has been considered for many years as the aetiologic agent of gastritis, peptic ulcer, gastric cancer and mucosal-associated lymphoid tissue lymphoma. The prevalence of H. pylori infection and the effect of eradication in a series of 69 idiopathic thrombocytopenic purpura patients were investigated. H. pylori infection has been documented in 35 of 69 chronic ITP patients [50.7%] by 13C urea breath test and confirmed by histologic examination. There was a significant increase in the percentage of patients responding to corticosteroid therapy in uninfected group compared to infected patients with H. pylori [85 % vs 62.5%]. There was a significant increase in platelet count in all infected patients after eradication therapy for H. pylori infection. H. pylori eradication may provide a good option for treatment in some idiopathic thrombocytopenic purpura patients