Evaluation of liver functions in combined infection with fasciola and schistosoma mansoni

In Egypt, it was reported that Fasciola and Schistosoma mansoni occasionally co-exist in the same patients. The present work was designed to evaluate some liver function tests in cases with fascioliasis acute and chronic [single or combined with S. Mansoni infection]. The total serum proteins and electrophoretic pattern were also studied. Indirect hemagglutination test was carried out for diagnosis of fascioliasis and to determine if there is cross-reaction with S. mansoni infection. It could be concluded that liver affection resulting from fascioliasis is aggravated by a-concomitant hepatic schistosomiasis

study on hepatitis B surface [Bs] antigen and auto-antibodies in patients with fascioliasis

A considerable, unexplained liver damage was reported in human fascioliasis. The present work explored the probability of adjoined hepatitis B surface [HB[S]] antigen and auto immunity in intensification of this pathological state. Nineteen patients with chronic infection were examined clinically. The intensity of infection and specific antibody level determined. The haematological parameters and liver functions were studied. Search for HB[S] antigen, anti nuclear and anti mitochondrial antibodies was undertaken. Hepatitis B surface [HB[S]] antigen and antimitochondrial antibodies were not detected in any case. Antinuclear antibodies were observed in cases with relatively high infection intensity. It was concluded that an auto immune process might intensify the liver injury initiated by fasciola infection

Human fascioliasis: ultrastructural study on the liver before and after bithionol treatment

The pathology of human fascioliasis was studied before and after bithionol treatment using light and transmission electron microscopy. Fine needle biopsies were taken from five patients, with established fascioliasis, before and after drug administration. By light microscope the pathology of human fascioliasis was similar to that reported in experimental fascioliasis. The ultrastructural picture revealed bile ductular hyperplasia, fibrosis of portal tracts, widening of the interhepatic spaces by many microvilli and dilated Disse space with collagen fibres. Bile ductular hyperplasia may be the initial factor to fibrinogenesis, which subsequenetly enhance the development of the microvilli on the surface of the hepatocytes. Both light and electron microscopic studies revealed regression of the picture of fascioliasis to normal after bithionol treatment with no sign of toxicity on the liver

Evaluation of the health status of fishermen of lake Maryout: 1 parasitic infections

This work was carried out at lake Maryout to study the prevalence of parasitic infections among fishermen. 395 cases were selected randomly, stool and urine samples collected and examined for different parasites. 100 sera from fishermen in different age groups were collected and examined for Toxoplasma gondii infection by IHT. The obtained results indicated that A. lumbricoides and S. mansoni were the most prevalent intestinal parasites among fishermen. As regards Toxoplasma gondii infection a high level of seropositivity was found in examined samples. Cats could play an important role in transmission