Aneurysmal fibrous histiocytoma

A 45-year-old Indian man had a painful, slow growing swelling on the anterior aspect of the right thigh, clinically assumed to be a sebaceous cyst, associated with varicose veins and venous oedema of the right leg. The excised mass [25x23x15 mm] consisted of a large blood-filled space [20mm] devoid of endothelial cells surrounded by a wall [2 to 6 mm] with features of a fibrous histiocytoma. Tumor cells were positive for vimentin, macrophages were positive for MAC375 and focally for S100. Scattered T-lymphocytes present were CD3 positive, CD20 negative. The cyst lining was negative for factor VIIIRAg and CD34, Staining for actin, desmin, cytokeratin, Ki67 and PCNA was negative. Aneurysmal fibrous histiocytoma is a rare variant of cutaneous fibrous histiocytoma characterized by large blood-filled spaces devoid of endothelial cells. Because of the large size and rapid growth secondary to hemorrhage it may be clinically confused with cysts, benign and malignant tumors

Transfusion associated graft versus host disease

A 70-year-old man developed a skin rash with fever, vomiting and diarrhea ten days after partial gastrectomy for gastric adenocarcinoma which had metastasized to intra-abdominal lymph nodes and liver. Four days later a skin biopsy confirmed the clinical diagnosis of transfusion associated graft versus host disease. His condition deteriorated with jaundice, high liver enzymes, leukopenia and thrombocytopenia. He died 19 days after surgery

Papulonecrotic tuberculid [case report]

We present in this article a 48 years old female who suffered from papulonecrotic tuberculid for 4 years. The diagnosis is based on the clinical picture, the highly positive tuberculin test, the histopathologic findings and the history of contact with an open pulmonary tuberculosis

Cysticercosis report of three cases form Qatar

This article reports three cases of cysticercosis seen in the State of Qatar between 1983 to 1996. The lesion in case 1 was present in the left side of the neck in a 24-year-old Indian woman, simulating branchial cleft cyst; In case 2 the cyst had involved soft tissue and muscle of the chest wall in a 17-year- old Qatari girl, presenting as left breast mass, presumed to be a fibradenoma; Case 3 was a 24-year- old Bangladeshi man who presented with discharge from the left eye which on ophthalmologic examination was found to be from a conjunctival cyst. He had a history of headache and double vision. A brief account of the geography, life cycle, clinical features, pathology, diagnosis and treatment of cysticercosis is presented

Cutaneous meningioma: clinicopathologic and immunohisto-chemical features of two cases with a brief review of the literature

Cutaneous meningiomas are rare lesions of the scalp and back which are generally present at birth but may be detected during childhood or early adulthood. Two cases are described: in the paravertebral [D4] region of a 24-year old man and in the parietal region of a 2-year-old girl. Diagnostic histological features includes psammoma bodies, small collagenous bodies and varying degrees of meningiothelial proliferation. Cutaneous meningiomas show extensive ultrastructural and immunophynotypic similarities to intracranial meningiomas including widespread expression of vimentin and epithelial membrane antigen. Cutaneous meningiomas probably originate from arachnoid cell nests misplaced into the skin during embryogenesis and occur around sensory organs, cranial and peripheral nerves

Liver pathology in non-transfused thalassemia patients

Iron overload, hepatic fibrosis and cirrhosis are well recognized findings in thalassemic patients with multiple blood transfusions. Since most studies have been performed in patients receiving multiple transfusions, we selected 15 children with thalassemia major and intermediate, who had never been transfused. Our studies in 6 female and 9 males, aged 2 - 11 years, showed hepatic extramedullary haematopoiesis, but no fibrosis or cirrhosis. Iron pigments were also present from grade +1 to + 3 and correlated well with increasing age. Furthermore liver function tests were normal. It thus appears that hepatic fibrosis and cirrhosis are long term post-transfusions complications while iron overload may be present even in non-transfused patients

Concurrent thymoma and primary small intestinal lymphoma: a report of two cases

Primary small intestinal lymphoma and thymoma have been simultaneously found in two Iranian men. The lymphoma in Case 1 presents fairly typical features of Mediterranean small intestinal lymphoma. The lymphoma in Case 2 is a well differentiated small round lymphocytic lymphoma of the small intestine. Immunoperoxidase staining performed on one of the thymoma was positive for keratin. Association of thymoma with non-thymic tumors is discussed