Sujets)
(Pyridin-2-ylméthyl)sulfinyl-1H-benzimidazoles/usage thérapeutique , Adolescent , Adulte , Sujet âgé , Amoxicilline/usage thérapeutique , Antiulcéreux/usage thérapeutique , Association de médicaments , Femelle , Infections à Helicobacter/traitement médicamenteux , Helicobacter pylori/effets des médicaments et des substances chimiques , Humains , Mâle , Adulte d'âge moyen , Oméprazole/usage thérapeutique , Études prospectives , Pompes à protons/antagonistes et inhibiteurs , Maladies de l'estomac/traitement médicamenteux , Tinidazole/usage thérapeutique , Résultat thérapeutiqueRésumé
The present prospective one year, study enrolled 265 symptomatic patients of acid peptic disease, out of which 92 patients were found H. pylori positive (by biopsy urease test and histopathological test) giving a prevalence of 34.71% . Among H. pylori positive patients, 64.13% were males and 35.86% were females. Age wise distribution showed maximum prevalence of H. pylori infection in the age group of 36-45 years and minimum in the age group of 66-75 years. Pain upper abdomen was the most frequent symptom in 49 (54.20%) patients followed by fullness after meals and retrosternal burning. Endoscopic and histopathological examination of H. pylori positive patients revealed chronic superficial gastritis in 87 (94.56%) patients followed by duodenitis in 11 (11.95%) and oesophagitis 8 (8.6%). All the positive patients were given anti-H. pylori treatment.
Résumé
In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.
Sujets)
Absorption , Adulte , Préparations à action retardée , Hydrates de carbone alimentaires/pharmacologie , Matières grasses alimentaires/pharmacologie , Protéines alimentaires/pharmacologie , Consommation alimentaire/physiologie , Jeûne , Femelle , Période , Humains , Mâle , Théophylline/pharmacocinétiqueRésumé
The effect of Aspirin, paracetamol and analgin on the kinetic profile of a single oral dose of chloroquine was studied in 8 healthy subjects. Aspirin did not alter the kinetic parameters of chloroquine whereas paracetamol and analgin significantly enhanced the Cmax and AUC0-alpha of chloroquine (P < 0.01, < 0.05 respectively).
Sujets)
Acétaminophène/pharmacologie , Adulte , Acide acétylsalicylique/pharmacologie , Chloroquine/sang , Métamizole sodique/pharmacologie , Interactions médicamenteuses , Humains , Mâle , Modèles biologiquesRésumé
The pharmacokinetics and bioavailability of valproic acid was compared in six healthy volunteers after single dose oral administration of 400 mg of the drug in tablet, capsule and syrup form in a crossover manner. Blood samples were collected for 48 hours and valproic acid concentration analysed by enzymatic immunoassay. Following the administration of the three dosage forms, the absorption varied (Ka = Syrup K 2.64 +/- 0.5; tablet 1.57 +/- 0.22; and capsule 0.55 +/- 0.55 h-1). Valproic acid concentration reached a peak level of 102.3 micrograms.ml at 1.9 h after syrup administration, 73 micrograms/ml at 3.3 h after tablet and 44.8 micrograms/ml at 5.4 h after capsule. The bioavailability of tablet and syrup formulation was not significantly different from each other but it differed from capsule form in that the bioavailability was only 52%.