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1.
Southeast Asian J Trop Med Public Health ; 2003 ; 34 Suppl 2(): 51-5
Article Dans Anglais | IMSEAR | ID: sea-33391

Résumé

The in vitro antimalarial activities against Plasmodium falciparum K1 of four extracts from the stembark of Picrasma javanica B1; ie water, methanol, chloroform and hexane extracts were studied using a modification of the [3H]hypoxanthine incorporation method. It was found that the hexane extract showed in vitro antimalarial activity with IC50 of 3.3 microg/ml. The extract was further fractionated using quick column chromatography, resulting in ten fractions. Fraction V was the most effective against P. falciparum K1 with IC50 of 4.4 microg/ml. Further isolation of fraction V using a column chromatographic technique provided six fractions. According to 1H- and 13C-NMR spectra, it could be concluded that the major compound in fraction V-3 was beta-sitosterol. Unfortunately, the antimalarial activity of beta-sitosterol could not be determined because of its low solubility in DMSO. However, fractions V-2 and V-4 still showed in vitro antimalarial activities with IC50 of 2.8 and 3.4 microg/ml, respectively. The further fractionation of these two active fractions could lead to promising candidates as antimalarial agents.


Sujets)
Animaux , Antipaludiques/pharmacologie , Relation dose-effet des médicaments , Concentration inhibitrice 50 , Spectroscopie par résonance magnétique , Picrasma , Écorce , Extraits de plantes/pharmacologie , Plasmodium falciparum/effets des médicaments et des substances chimiques , Thaïlande
2.
Southeast Asian J Trop Med Public Health ; 1982 Dec; 13(4): 618-27
Article Dans Anglais | IMSEAR | ID: sea-32227

Résumé

Beta thalassaemia in Thailand is heterogeneous. Clinical, genetical, haematological and globin chain biosynthetic studies were performed in seven beta-thalassaemia families. The results showed different gene combinations. These were alpha-thalassaemia/homozygous beta 0-thalassaemia, questionable double heterozygosity between a beta-thalassaemia and a silent beta-thalassaemia genes with low Hb F of unexplained cause, silent beta-thalassaemia/beta+ - or beta 0-thalassaemia, high Hb A2 high Hb F-beta-thalassaemia - a new mutant, mild beta+-thalassaemia/Hb E, and beta 0-thalassaemia/heterocellular HPFH or delta beta-thalassaemia associated with alpha-thalassaemia. Most of variability of clinical and haematological findings in these families is due to heterogeneity of the beta-thalassaemia and related genes.


Sujets)
Adolescent , Adulte , Sujet âgé , Enfant , Femelle , Hémoglobine foetale/analyse , Hémoglobine A/analyse , Hémoglobine E/analyse , Hétérozygote , Homozygote , Humains , Mâle , Adulte d'âge moyen , Pedigree , Thalassémie/sang
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