Possible association of HLA-DR and DQ molecules with colorectal cancer in Iraqi patients

Human leukocyte antigen [HLA] is the most polymorphic genetic system in man. The genes of this region influnence susceptibility to certain diseases. This study was established to shed light on the possible association of HLA class-II antigens and CRC patients, and to correlate the findings with both family history and tumor location. Microlymphocytotxicity assay has been used to assess HLA-typing of 150 blood samples of 100 CRC patients and 50 healthy normal control. An increased frequency of HLA-DR7 was observed for patients' group versus control group with P-value [<0.005], moreover, statistical analysis showed non significant correlation of HLA-DR7 with both family history of CRC and tumor location. This finding demonstrate that HLA-DR7 might play a role in CRC susceptibility

Possible association between class-I HLA molecules and idiopathic nephrotic syndrome

Nephrotic Syndrome [NS] is a clinical entity having multiple causes, characterized by increased glomerular permeability manifested by massive protein urea with variable tendency towards edema, hypoalbuminemia and hyperlipidemia. Microlymphocytotoxicity has been applied for Class-I HLA typing of 67 Iraqi Nephrotic syndrome children's blood samples in comparison with 107 apparent healthy controls. This study revealed that there is a significant difference in HLA-B21 molecule frequency among the nephrotic syndrome patients in comparison with control group [P<0.0003] with OR of 4.8. Negative association was observed between HLA-B5 and disease [P < 0.0001] with Inverse OR of 9.6. Neither HLA-A molecules nor HLA-Cw molecules showed significant frequencies. It was concluded that HLA-B molecules [B21] may associate with the disease development, while [B5] may be considered as a protective factor