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Braz. j. med. biol. res ; 34(2): 271-280, Feb. 2001.
Article Dans Anglais | LILACS | ID: lil-281607

Résumé

The "regional basic diet" or RBD is a multideficient diet (providing 8 percent protein) which is known to produce dietary deficiencies in some populations in northeastern Brazil. The present study investigated the effects of RBD-induced malnutrition on resting blood pressure and baroreflex sensitivity in conscious rats. Malnourished rats were obtained by feeding dams the RBD during mating and pregnancy (RBD-1 group) or during nursing and a 10-day period after weaning (RBD-2 group). At 90 days of age, only RBD-2 rats weighed significantly (P<0.001) less than control rats born to dams fed a standard commercial diet (23 percent protein) during pregnancy and nursing. Baseline mean arterial pressure and heart rate of both RBD-1 and RBD-2 rats were comparable to those of controls. The slopes for both reflex bradycardia and tachycardia (bpm/mmHg) induced by intravenous phenylephrine and sodium nitroprusside, respectively, were unchanged in either RBD-1 (-2.08 0.11 and -3.10 0.43, respectively) or RBD-2 (-2.32 0.30 and -3.73 0.53, respectively) rats, when compared to controls (-2.09 0.10 and -3.17 0.33, respectively). This study shows that, after a prolonged period of nutritional recovery, the patterns of resting blood pressure and baroreflex sensitivity of both pre- and postnatally malnourished rats were similar to those of controls. The decreased body weight and the tendency to increased reflex tachycardia in RBD-2 rats may suggest that this type of maternal malnutrition during lactation is more critical than during pregnancy


Sujets)
Animaux , Mâle , Femelle , Rats , Grossesse , Baroréflexe , Pression sanguine , Régime alimentaire/effets indésirables , Malnutrition protéinocalorique/étiologie , Analyse de variance , Poids de naissance , Brésil , Études cas-témoins , Sédation consciente , Rythme cardiaque , Malnutrition protéinocalorique/complications , Rat Wistar , Tachycardie/étiologie
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