One case of bacterial meningitis caused by Brevundimonas vesicularis / 中华神经科杂志

Brevundimonas vesicularis is a rare opportunistic pathogen, which is rare in clinical practice, especially in cases of central nervous system infection. There are no reports in China, and only one case is reported abroad. We analyzed the clinical data of one case of bacterial meningitis caused by Brevundimonas vesicularis in our department, in order to improve the understanding of the disease.

Study on Medication Rules of Treatment of Stroke in Gu Jin Ming Yi Lin Zheng Jin Jian Zhong Feng Juan / 中国中医药信息杂志

Objective To analyze the medication rules of the treatment of stroke in Gu Jin Ming Yi Lin Zheng Jin Jian Zhong Feng Juan; To provide references for the clinical treatment. Methods Prescriptions with confirmed efficacy of famous TCM doctors in the history in Gu Jin Ming Yi Lin Zheng Jin Jian Zhong Feng Juan was searched. Excel2003 was used to establish database to analyze medication frequency. SPSS17.0 statistical software was used to conduct cluster analysis, and tree view was used to show results. Results Totally 112 prescriptions for the treatment of stroke of 36 famous TCM doctors were included in the study, including 204 kinds of Chinese materia medica and 1169 times of medication frequency. The high-frequency medicines (>10 times) were Paeoniae Radix Alba, Achyranthis Bidentatae Radix, Angelicae Sinensis Radix, Pinelliae Rhizoma Praeparatum, and Poria. The high-frequency medicine categories were tonifying deficiency medicine (22.58％), pacifying liver and wind medicine (12.31％), activating blood and dispelling stasis medicine (11.89％), clearing heat medicine (11.46％) and dissipating phlegm, cough and asthma medicine (8.72％). Cluster analysis showed that high-frequency medicine (>10 times) could be clustered as 6 categories. Conclusion Gu Jin Ming Yi Lin Zheng Jin Jian Zhong Feng Juan focuses on tonifying deficiency medicine, accompanied with pacifying liver and wind medicine, activating blood and dispelling stasis medicine, clearing heat medicine and dissipating phlegm, cough and asthma medicine, which can be used to guide clinic.

Study on the relationship between the expression of CA242 and CD_(44v6) and their clinicopathologic significance in gastric carcinoma / 肿瘤研究与临床

Objective To investigate the expression of CA242 and CD_(44v6) protein in gastric cancer (GC) and its clinical significance. Methods Immunohistochemical staining was used to detect the expression of CA242 and CD_(44v6) protein in 120 cases of GC, 30 cases of gastric epithelial dysplasia and 20 cases of normal gastric mucosa. The pathological feature of GC and clinical follow-up data was also analysed. Results The positive rate of CA242 and CD_(44v6) was 79.2 % and 81.7 %, respectively in primary GC. The positive rate of CA242 and CD_(44v6) in GC was higher than that in epithelial dysplasia and normal gastric mucosa (P <0.05). The expression of CA242 and CD_(44v6) was closely related to infiltration of serosa, metastasis of lymph node and prognosis of patients (P <0.05). Conclusion These data suggest that the expression of CA242 and CD_(44v6)is closely related to carcinogenesis, metastasis and survival rate in GC. CA242 and CD_(44v6) may be prognostic indicators of GC.

Expression of CD44v6 and E-cadherin in prostate carcinoma and metastasis of prostate carcinoma / 中华男科学杂志

<p><b>OBJECTIVE</b>To study the expression of CD44v6 and E-cadherin(ED) in prostate carcinoma in relation to the metastasis of prostate carcinoma.</p><p><b>METHODS</b>The expression of CD44v6 and ED in 45 cases of prostate carcinoma was studied with immunohistochemical technique.</p><p><b>RESULTS</b>The positive expression rates of CD44v6 and ED in prostate carcinoma were 77.8% and 48.9%, respectively. The high level expression of CD44v6 and the low level expression of ED were positively correlated with differentiation, clinical staging and metastasis of prostate carcinoma (P < 0.05). The expression of CD44v6 was negatively correlated with ED(r = -0.58, P < 0.005).</p><p><b>CONCLUSIONS</b>The expression of CD44v6 and ED protein might be a useful marker for prostate carcinoma in evaluating the biological behavior and prognosis of the tumor.</p>

Paroxetine in treatment of generalized anxiety / 中国新药与临床杂志

AIM: To investigate the clinical effect and side-effects of paroxetine in the treatment of generalized anxiety (GA). 　METHODS: Ninety patients who met Chinese classification and diagnostic criteria of mental disorders, 2nd Rev Ed (CCMD-2-R) criteria for GA were randomly divided into paroxetine group of 30 patients (M 12, F 18; age 40 a±s 13 a) which was treated with paroxetine 20-40 mg, po, qd or bid, benzodiazepines group of 30 patients (M 13, F 17; age 37 a±13 a) among them, 16 patients were treated with alprazolam 0.4-0.8 mg, po, bid or tid, 14 patients were treated with clonazepam 1-2 mg, po, bid or tid and placebo group of 30 patients (M 11, F 19; age 37 a±13 a) which was treated with placebo 1 tablet, tid for 12 wk. Effects were evaluated with Hamailton anxiety scale (HAMA), self-rating anxiety scale (SAS), clinical global impression scales (CGI) and treatment emergent symptoms scale (TESS), before and after the wk 2,4,8,12 of treatment.　RESULTS: The excellent response rates of paroxetine group and benzodiazepines group were 90 % and 50 % (P<0.01). The side-effects of paroxetine group were dry mouth, constipation, nausea, but those were less than that of benzodiazepines group. 　CONCLUSION: The study suggests that paroxetine is an effective drug for the long treatment of GA and the side-effect is less.

Topiramate vs sodium valproate in treating refractory epilepsy / 中国新药与临床杂志

AIM: To compare the effects between topiramate and slow-release sodium valproate in treating refractory epilepsy. 　METHODS: Topiramate group of 39 patients (M 21, F 18; age 28 a± s 20 a) was compared with sodium valproate group of 41 patients (M 22, F 19; age 27 a±17 a) in antiepileptic effect of refractory epilepsy. Adult's and children's dosages of topiramate were increased gradually about 200 mg*d-1 and 4 mg*kg*d-1 respectively during about 2 mo, po, bid, for 6 mo as a course. Adult's dosage of slow-release sodium valproate was 0.5-1 g*d-1, and children's was increased gradually to total dosage: 15-30 mg*kg*d-1, po, qd or bid (morning or morning and noon), for 6 mo as a course. Effects were analysed between these two drugs after treatment 4 and 6 mo.　RESULTS： Simple and complex partial seizures with or without secondary generalized seizure, in topiramate group were much more improved than these in sodium valproate group 6 mo after treatment. Four patients of topiramate group appeared temporary adverse reactions of central nervous system, such as tiredness, sleepiness and distraction, but one patient of sodium valproate group had severer decreased function of bone marrow.　CONCLUSION: Topiramate is one of effective antiepileptic drugs and superior to slow-release sodium valproate. There are the apparent absence of any effects of topiramate on the bone marrow and on indexes of liver and kidney.

Clinical observation on effcets of paroxetine and alprazolam in the treatment of elderly patients with chronic primary insomnia / 中华老年医学杂志

Objective To investigate the clinical effect and the safety of paroxetine in the treatment of elderly patients with chronic primary insomnia. Methods Ninety elderly patients who met Chinese Classification and Diagnostic Criteria of Mental Disorders, 2nd Rev Ed, (CCMD 2 R) for elderly patients with chronic primary insomnia were randomly divided into paroxetine group (30 cases), alprazolam group (30 cases), and placebo group (30 cases) for 12 weeks as a course. Effects were evaluated with Pittsburgh Sleep Quality Index (PSQI) and treatment emergence symptoms scale (TESS) before and after the 4th, 8th, 12th week of treatment. Results The excellent response rate of paroxetine group and alprazolam group were 83% and 53% respectively( P

Significancy of expression of tumor suppressor gene PTEN and p16 protein in cholangiocarcinoma / 中国普通外科杂志

Objective To investigate the relationship between the expression of tumor suppressor gene PTEN and p16 protein and the biologcal behaviors of cholangiocarcinomas.Methods The expression of PTEN and p16 protein in 43 of cholangiocarcinoma tissues and 10 chronic cholangitis tissues were investigated by immunohisto-chemical technique.The relationship between expression of PTEN and p16 protein and the clinicopathological parameters of cholangiocarcinoma was analyzed. Results The positive expression rate of PTEN and p16 protein in cholangiocarcinoma was 39.5% and 44.2%,respectively.The expression of PTEN and p16 protein were positively relatad with the TNM staging,differentiation degree and metastasis of cholangiocarcinoma (P