A plasmodium ovale-like parasite in the blood of a native Filipino

A plasmodium ovale-like organism occurring in the blood of a native Filipino is reported. If this is actually a Plasmodium ovale infection it will be its second appearance in the Philippines. The morphology of the parasite is briefly described and some specific diagnosis points are given. (Summary)

Comparative potency of some official gastro-intestinal antispasmodics as studied in experimental animals

1. The antispasmodic effect of some official drugs were studied in dogs using balloons appropriately placed on the intact enteric tract. Intestinal contractions were kymographically recorded2. Comparable doses (threshold relaxing doses) of the pharmacologic agents were determined and tested under uniform experimental conditions3. Tested against spontaneous, Barium-stimulated and Pilocarpine-stimulated intestinal contractions, Methantheline and Atropine were shown to be the most potent agents. Aminophylline, Papaverine and Glyceryl trinitrate follow in the order named. This comparison is on the basis of the average duration of their respective inhibiting effect on the intestine4. The experimental findings in this method of study appear to be in close agreement with clinical observations5. It is postulated that in certain gastro-intestinal conditions characterized by hyperperistalsis, spasm and pain, these antispasmodics will prove clinically effective, if wisely administered. (Summary and Conclusions)

Anti-hemoptic drugs: I. Pitressin- a reinvestigation of its actions on the pulmonary circulation

1) In anesthetized artificially respiring dogs, Pituitrin causes a rise of systematic and fall of pulmonary pressure; Pitressin elicits a similar response to Pituitrin but the effects are relatively greater in degree2) A measured by a bubble flowmeter, Pitressin brings about decreased blood flow through the pulmonary circuit3) Lung perfusion experiments sustain the claim that Pitressin actually constricts the pulmonary vessels4) It is inferred from past and present experimental evidences that the pulmonary hypotension and the diminished pulmonary blood flow after Pitressin injection as attributable to depressed cardiac efficiency5) Our investigation give indication that Pitressin may enjoy widespread clinical use in the treatment of pulmonary hemorrhage, especially those cases attended with significant blood loss. (Summary and Conclusion)

Hetrazan on ascarigram

Hetrazan is an ascarifuge or a vermifuge and not an ascaricide in these vitro studiesIts vermifugal action is not dependent on its ability to lower the hydrogen ion concentration of the solutionThe anthelmintic action is not modified qualitatively by varying the strength of the solution. (Summary and Conclusion)

Anti-henoptic drugs: its effects of nitroglycerin (NG) on the pulmonary circulation

1. Nitroglycerin, 10 to 5000 mcg./kg. intravenously, caused pulmonary hypotension in 10 dogs. In these 10 dogs, left and right atrial pressure measurements do not support the possibility that the pulmonary hypotension is secondary to decreased right ventricular output or increased left ventricular output2. Nitroglycerin, intra-arterially administered in 12 dogs prepared for constant inflow perfusion, caused a decrease in perfusion pressure in 11 and no change in one. Decrease in pulmonary perfusion pressure can be shown to occur with doses which cause no change in systemic blood pressure. Furthermore, when the intra-arterial doses of NG are large enough to bring about the known systemic hypotensive property of NG, the fall in pulmonary perfusion pressure always precedes the systemic hypotension. These phenomena speak speak strongly of a pulmonary vasodilatation caused by NG. No experiments were done to determine what role decreased transpleural pressure plays in the pulmonary vasodilatation3. Nitroglycerin, 10 mcg. to 12 mg. total doses, caused no change in the cardiac output of 8 dog heart-lung preparations4. The efficacy of NG, interavenously, as an anti-hemoptic was discussed.(Summary)