Effect of glucose loading on uric acid clearance in cases of primary hyperuricaemia

The effect of glucose loading on uric acid clearance was studied in 15 male nondiabetic patients with primary hyperuricemia in addition to 16 normouricemic nondiabetic male subjects as controls. Serum glucose, uric acid and creatinine clearances were measured before and during oral glucose tolerance test [OGTT] along 3 hours [0.5, 1, 2 and 3 hours] after glucose intake [1 g of glucose/kg body weight]. The serum glucose levels of fasting and at one and two hours after glucose intake were significantly higher in the hyperuricemic group than the control group. Uric acid clearance before and after glucose intake did not change significantly in both control and hyperuricemic groups. There was no significant difference between both groups as regards the clearance ratio of uric acid to creatinine [Cua/Ccr] before and during OGTT. Also, there was no correlation between serum glucose level and Cua/Ccr ratio in both groups before and during OGTT. From these results, it could be concluded that glucose loading has no effect on uric acid clearance in cases of primary hyperuricemia

Chromium red cell survivial hepatosplenic schistosamiasis

The red-cell survival was studied in eight patients with hepatomegalic schistosomiasis with slight or moderate enlargement of the spleen. The CR[51] red cell half-life ranged between 15 and 30 days with four patients definitely below the lowest I'mit of normal of 25 days indicating mere rapid destruction of erythrocytes. As evidences of haemolysis could not be demonstrated in these patients, this might be due to chronic and slowly continuous red cell destruction. The size of the spleen did not correlate with the presence or absence of shortened red-cell half-life. It seems that a deranged spleen circulation secondary to a severer degree of portal hypertension may be the factor that determines intrasplenic red-cell destruction rather than the size of the spleen