Résumé
The utilization of N-bromosuccinimide [NBS] and N-chlorosuccinimide [NCS] for titrimetric determination of anti-inflammatory drug azapropazone was described. The study of stoichiometry of the reactions revealed that 1 mole of azapropazone reacts with 4 moles NBS and 2 moles of NCS. The optimum time for complete the reaction was found to be 10 minutes in cases of NBS and NCS. The method was successfully applied for the determination of azapropazone in bulk powder and prolixan capsules. The reaction product of azapropazone with NBS was isolated and investigated by instrumental analysis and reaction pathway was proposed. Also, suggested reaction pathway for investigated drug with NCS was proposed
Sujets)
Poudres/analyse , Préparations pharmaceutiques/analyse , N-Bromo-succinimide , Succinimides , TitrimétrieRésumé
Two simple and accurate procedures are described for colorimetric determination of anti-inflammatory drug, azapropazone. The procedures involve the use of N-bromosuccinimide [NBS] and N-chlorosuccinimide [NCS] for determining azapropazone in bulk powder and pharmaceutical formulation. The optimum reactions conditions were studied. In the first procedure, azapropazone was dissolved in ethanol, treated with NBS solution [1%, 5 ml] and sulfuric acid [5 ml]. The red color produced exhibits and absorption maximum at 488 nm. Different concentrations ranging from 80 to 320 muml-1 of azapropazone were measured. In the second procedure, the yellow color developed upon the treatment of azapropazone with NCS solution [0.5%, 2 ml] in different media exhibits an absorption maximum at 451 nm. Linearity of the absorbance of yellow color versus the concentration of azapropazone was verified in the ranges 5-50, 20-100 mug m1-1 for aqueous, acidic and basic media, respectively. Both procedures described here were applied for the determination of azapropazone in the pure state and in prolixan capsules. The procedures proposed here are precise and reproducible