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Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 36(4): 322-329, Oct-Dec/2014. graf
Article Dans Anglais | LILACS | ID: lil-730589

Résumé

Objective: To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. Methods: On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 × 106 CFU/mL and remained with their mothers until age 21 days. Animals were divided into the following groups: control, control + EE, meningitis, and meningitis + EE. EE began at 21 days and continued until 60 days of age (adulthood). EE consisted of a large cage with three floors, ramps, running wheels, and objects of different shapes and textures. At 60 days, animals were randomized and subjected to habituation to the open-field task and the step-down inhibitory avoidance task. After the tasks, the hippocampus and CSF were isolated for analysis. Results: The meningitis group showed no difference in performance between training and test sessions of the open-field task, suggesting habituation memory impairment; in the meningitis + EE group, performance was significantly different, showing preservation of habituation memory. In the step-down inhibitory avoidance task, there were no differences in behavior between training and test sessions in the meningitis group, showing aversive memory impairment; conversely, differences were observed in the meningitis + EE group, demonstrating aversive memory preservation. In the two meningitis groups, IL-4, IL-10, and BDNF levels were increased in the hippocampus, and BDNF levels in the CSF. Conclusions: The data presented suggest that EE, a non-invasive therapy, enables recovery from memory deficits caused by neonatal meningitis. .


Sujets)
Animaux , Mâle , Facteur neurotrophique dérivé du cerveau/sang , Troubles de la cognition/thérapie , Cytokines/sang , Exposition environnementale , Troubles de la mémoire/thérapie , Méningite à pneumocoques/thérapie , Encéphale/physiopathologie , Modèles animaux de maladie humaine , Test ELISA , Neurogenèse/physiologie , Plasticité neuronale/physiologie , Rat Wistar , Récupération fonctionnelle , Reproductibilité des résultats , Résultat thérapeutique
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