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China Journal of Chinese Materia Medica ; (24): 2066-2070, 2008.
Article Dans Chinois | WPRIM | ID: wpr-283796

Résumé

<p><b>OBJECTIVE</b>To study the cyclodextrin inclusion complexes of Dragon's blood for improving the drug solubility and the preparation.</p><p><b>METHOD</b>The inclusion complexes were prepared with beta-cyclodextrin, HP-beta-cyclodextrin, SBE-beta-cyclodextrin and confirmed by DTA. The activity of the inclusion complex was tested by animal experiments. Inclusion complexes tablets were prepared and the dissolution test was performed.</p><p><b>RESULT</b>The solubility of inclusion complexes was increased to 13. 75-168. 39 times. The activity of the inclusion complex was markedly improved, and dissolution rate was 78.69%.</p><p><b>CONCLUSION</b>The cyclodextrin inclusion complexes of Dragon's blood have a good solubility, dissolution rate and pharmacological activity.</p>


Sujets)
2-Hydroxypropyl-beta-cyclodextrin , Cyclodextrines , Chimie , Stabilité de médicament , Médicaments issus de plantes chinoises , Chimie , Extraits de plantes , Chimie , Solubilité , Comprimés , Chimie , Cyclodextrines bêta , Chimie
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