Résumé
Multidrug resistance(MDR)is one of the important reasons for the failure of chemotherapy in clinic,whereas the mechanism of MDR is very complicated. At present,it is considered that the efflux protein P-glycoprotein(P-gp)is one of the main factors which can lead to MDR,descreasing the successful rate of chemotherapy because chemotherapeutics with different structures and functions can be effluxed by P-gp. Flavonoids are found in many kinds of plants and have a wide range of pharmacological activi?ties. Besides,recent studies have reported that flavonoids can reverse the MDR of tumor and affect the expression and function of ef?flux transporter,especially P-gp. In this review,we elucidate the mechanisms of flavonoids reversing tumor MDR mediated by P-gp from the following aspects:inhibition of P-gp protein expression,inhibition of P-gp efflux function,and prevention of combining P-gp and its substrate,etc. The review can provide some ideas and references for the application of flavonoids in tumor therapy.