Assessment of antibody titre in patients with meningococcal meningitis group A versus post vaccination in high risk groups

This study have been carried out from March 1992 to April 1994. During this period 125 cases were admitted with meningococcal meningitis. 111 cases [88.8%] were due to Neisseria Meningitides group [A], 11 cases [8.8%] due to N. Meningitides group [W135] and 3 cases [2.4%] due to N. Meningitides group [C]. 20 cases were studied for the antibody titer to N. Meningitides group A during convalescent and 6 months later. 70 individuals of high risk group were studied for the antibody titer 1 month, 6 months and 1 year post-vaccination. There was significant difference in the antibody titer between the sample of patients 6 months post-infection and vaccines 6 months post- vaccination. So, it was concluded that higher antibody titers are produced with systemic infection than following vaccination

Clinical aspect and factors affecting outcome of meningococcal infection in Makkah

This study included 125 cases with meningococcal infection The majority of cases were due to group A meningococci [88.8%], most of them admitted in Ramaddan time of Umra in Makka. High incidence of the disease developed in the age group 24-60 years and the males were affected more than females. Fever, headache, vomiting, disturbed level of consciousness and neck stiffness were the predominant symptoms and signs. The mortality rate was relatively high [20.8%]. A significant relationship was found between the death and extensive rashes, leucopenia, normal WBCs count, shock and disturbed level of consciousness grade II, IV, but no significant relationship between the death and C. S. F pleocytosis, petechiae, peripheral leucocytosis and stage I and disturbed level of consciousness