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1.
Clinics ; 74: e739, 2019. tab
Article Dans Anglais | LILACS | ID: biblio-989646

Résumé

OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.


Sujets)
Humains , Femelle , Adulte d'âge moyen , Sujet âgé , Polymorphisme génétique/génétique , Ostéoporose post-ménopausique/génétique , Fractures du rachis/génétique , Fractures ostéoporotiques/génétique , Vitamin K epoxide reductases/génétique , Turquie , Densité osseuse , Projets pilotes , Études rétrospectives , Études d'associations génétiques , Fréquence d'allèle/génétique
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