Résumé
This study analyzed the perfusion of a random skin flap, after nicotine injection and administration of N-acetylcysteine (NAC). A skin flap was elevated after 6 weeks of nicotine administartion and the percentage of necrosis was determined thereafter, as well as malondialdehyde (MDA) in 4 selected skin areas and in serum. Both nicotine and NAC elicited elevation in MDA levels in the skin samples. Nicotine also led to elevation in serum MDA levels and in the percentage of flap necrosis. NAC did not improve the viability of the flap.
Sujets)
Animaux , Rats , Mâle , Acétylcystéine/effets indésirables , Agonistes nicotiniques/effets indésirables , Piégeurs de radicaux libres/effets indésirables , Nicotine/effets indésirables , Lambeaux chirurgicaux , Nécrose , Répartition aléatoire , Rat WistarRésumé
This study analyzed the perfusion of randomized skin flaps in rats after nicotine injections, in doses that could be compared with heavy and light smorkers. A skin flap was elevated after 12 weeks of nicotine adminsitration and the percentage of necrotic area was determined thereafter. There was a statistically significant difference between "heavy smokers" in the preoperative (G3) and preoperative and postoperative periods (G5), suggesting a deleterious effect of nicotine in the postoperative period