RÉSUMÉ
Objective To analyse the effect of Danhong injection on serum levels of cystatin C (CysC), homocysteine (Hcy) and inflammatory factors in elderly patients with chronic heart failure.Methods Fifty-two elderly patients who were diagnosed with chronic heart failure in our hospital were collected.All patients were randomly divided into experimental group and control group, 26 cases in each group, the control group were given conventional therapy, the experimental group received Danhong injection adjunctive therapy on the basis of the control group.After treatment, the serum levels of CysC, Hcy, nuclear transcription factorκB (NF-κB), interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), heart function and incidence of adverse reactions were detected in all patients.Results After treatment, compared with control group, the serum levels of CysC and Hcy were lower, the serum levels of NF-κB,IL-1βand TNF-αwere lower in the experimental group, and the levels of left ventricular ejection fraction ( LVEF) and stroke volume (SV) were lower in the experimental group, there were significant difference between two groups (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion The Danhong injection therapy could significantly reduce the serum levels of CysC, Hcy and inflammatory factors in elderly patients with chronic heart failure,reduce the inflammatory reaction, improve the heart function, and have high safety.
RÉSUMÉ
Objective To explore the noninvasive positive pressure ventilation combined with pulmonary function and blood gas analysis of chronic obstructive pulmonary disease(COPD)with type Ⅱ respiratory failure. Methods 120 COPD patients with type II respiratory failure were selected,they were randomly divided into the con-trol group and observation group by using the random number table method,with 60 cases each group.The control group was given conventional low flow oxygen therapy,the observation group was application of noninvasive positive pressure ventilation treatment.The change of blood gas levels,the forced expiratory volume in one second (FEV1 ), forced expiratory volume in one second to forced vital capacity ratio (FEV1 /FVC)before treatment and after one week treatment,and the intubation rate,the average hospitalization time were observed.Results After treatment,FEV1 , FEV1 /FVC (%),PaO2 ,pH of the two groups were higher than those before treatment,while PaCO2 was lower than that before treatment,the differences were statistically significant (t =8.33,12.56,14.71,10.82,7.88,10.14, 13.20,15.63,11.48,8.37,all P <0.05).FEV1 and FEV1 /FVC (%)of the observation group after treatment were (2.84 ±0.42)L and (69.93 ±0.72),which were higher than those of the control group after the treatment (2.69 ± 0.39)L and (67.11 ±0.78),the difference was statistically significant (t =8.95,10.76,all P <0.05).PaO2 and pH of the observation group after treatment were (77.90 ±1.12)mmHg and (7.41 ±0.10),which were higher than those of the control group after treatment (70.88 ±1.14)mmHg and (7.29 ±0.08),the difference was statistically significant (t =11.58,7.94,all P <0.05).PaCO2 of the observation group was (50.14 ±1.23)mmHg,which was lower than that of before treatment (54.26 ±1.12)mmHg,the difference was statistically significant (t =9.81,P <0.05).The intubation rate of the observation group was 1.67% (1 /60),which was lower than that of the control group 13.33% (8 /60),the difference was statistically significant (χ2 =7.90,P <0.05).The average hospital stay time of the observation group was (11.69 ±1.32)d,which was lower than that of the control group(15.10 ±1.28)d, the difference was statistically significant (t =9.84,P <0.05).Conclusion Noninvasive positive pressure ventila-tion could significantly improve lung function of COPD patients with type II respiratory failure,increase PaO2 ,improve the respiratory status of the patients,reduce intubation rate and shorten the hospitalization time.